Impact of Isolation measures on pregnancy outcome during the COVID-19 pandemic

Tao, Yu; Yang, Xiao; Wang, Fangyi; Liang, Yuxiu; Zhang, Jin; Xue, Fuzhong; Wang, Yongchao; Wang, Zhiping

doi:10.1016/j.ehb.2022.101196

Cited by 2 publications

(2 citation statements)

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“…The association between severe COVID-19 and LGA (1.53) is similar to the results reported by Munda et al (1.24) and Simon et al (1.38), though their associations were smaller in magnitude and not statistically significant 57 64. A higher proportion of macrosomia (12%) was reported among women who had pregnancies during lockdown, compared with pregnancies (9%) at the same time the preceding year 65. However, another study did not find difference in the proportions of LGA between prepandemic and pandemic epochs, as well as between those who tested positive or negative for SARS-Cov-2 62.…”

Section: Discussionsupporting

confidence: 86%

“…57 64 A higher proportion of macrosomia (12%) was reported among women who had pregnancies during lockdown, compared with pregnancies (9%) at the same time the preceding year. 65 However, another study did not find difference in the proportions of LGA between prepandemic and pandemic epochs, as well as between those who tested positive or negative for SARS-Cov-2. 62 The negative association observed for PTB, though consistent with a large meta-analysis comparing prepandemic with pandemic epochs, remains intriguing and we have no clear explanation.…”

Section: Discussionmentioning

confidence: 93%

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SARS-CoV-2 infection by trimester of pregnancy and adverse perinatal outcomes: a Mexican retrospective cohort study

Ghosh,

Gutierrez,

de Jesús Ascencio-Montiel

et al. 2024

BMJ Open

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ObjectiveConflicting evidence for the association between COVID-19 and adverse perinatal outcomes exists. This study examined the associations between maternal COVID-19 during pregnancy and adverse perinatal outcomes including preterm birth (PTB), low birth weight (LBW), small-for-gestational age (SGA), large-for-gestational age (LGA) and fetal death; as well as whether the associations differ by trimester of infection.Design and settingThe study used a retrospective Mexican birth cohort from the Instituto Mexicano del Seguro Social (IMSS), Mexico, between January 2020 and November 2021.ParticipantsWe used the social security administrative dataset from IMSS that had COVID-19 information and linked it with the IMSS routine hospitalisation dataset, to identify deliveries in the study period with a test for SARS-CoV-2 during pregnancy.Outcome measuresPTB, LBW, SGA, LGA and fetal death. We used targeted maximum likelihood estimators, to quantify associations (risk ratio, RR) and CIs. We fit models for the overall COVID-19 sample, and separately for those with mild or severe disease, and by trimester of infection. Additionally, we investigated potential bias induced by missing non-tested pregnancies.ResultsThe overall sample comprised 17 340 singleton pregnancies, of which 30% tested positive. We found that those with mild COVID-19 had an RR of 0.89 (95% CI 0.80 to 0.99) for PTB and those with severe COVID-19 had an RR of 1.53 (95% CI 1.07 to 2.19) for LGA. COVID-19 in the first trimester was associated with fetal death, RR=2.36 (95% CI 1.04, 5.36). Results also demonstrate that missing non-tested pregnancies might induce bias in the associations.ConclusionsIn the overall sample, there was no evidence of an association between COVID-19 and adverse perinatal outcomes. However, the findings suggest that severe COVID-19 may increase the risk of some perinatal outcomes, with the first trimester potentially being a high-risk period.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 93%