Impact of isoflurane on malignant capability of ovarian cancer in vitro

Luo, Xiangyu; Zhao, Hailin; Hennah, Lindsay; Ning, Jing; Liu, J.; Tu, Hanjun; Ma, Ding

doi:10.1093/bja/aeu408

Cited by 102 publications

(67 citation statements)

References 32 publications

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“…CXCR2 signaling is one of the pathways activated by such anesthetics. Inhibition of CXCR2 by siRNA abrogates migratory activities of anesthetics on ovarian cancer cells 257, 258. In separate studies it was shown that the Kaposi's sarcoma-associated herpesvirus (KSHV) miRNA, miR-K3, promotes angiogenesis, cell migration and invasion through GRK2/CXCR2/AKT signaling 259, 260.…”

Section: The Cxcl8-cxcr1/2 Axis In Cancermentioning

confidence: 99%

Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases

Ha¹,

Debnath²,

Neamati³

2017

Theranostics

554

464

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The chemokine receptors CXCR1/2 and their ligand CXCL8 are essential for the activation and trafficking of inflammatory mediators as well as tumor progression and metastasis. The CXCL8-CXCR1/2 signaling axis is involved in the pathogenesis of several diseases including chronic obstructive pulmonary diseases (COPD), asthma, cystic fibrosis and cancer. Interaction between CXCL8 secreted by select cancer cells and CXCR1/2 in the tumor microenvironment is critical for cancer progression and metastasis. The CXCL8-CXCR1/2 axis may play an important role in tumor progression and metastasis by regulating cancer stem cell (CSC) proliferation and self-renewal. During the past two decades, several small-molecule CXCR1/2 inhibitors, CXCL8 releasing inhibitors, and neutralizing antibodies against CXCL8 and CXCR1/2 have been reported. As single agents, such inhibitors are expected to be efficacious in various inflammatory diseases. Several preclinical studies suggest that combination of CXCR1/2 inhibitors along with other targeted therapies, chemotherapies, and immunotherapy may be effective in treating select cancers. Currently, several of these inhibitors are in advanced clinical trials for COPD, asthma, and metastatic breast cancer. In this review, we provide a comprehensive analysis of the role of the CXCL8-CXCR1/2 axis and select genes co-expressed in this pathway in disease progression. We also discuss the latest progress in developing small-molecule drugs targeting this pathway.

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Section: The Cxcl8-cxcr1/2 Axis In Cancermentioning

confidence: 99%

Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases

Ha¹,

Debnath²,

Neamati³

2017

Theranostics

554

464

View full text Add to dashboard Cite

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“…This effect was terminated when IGF-1 signalling was blocked either by a neutralizing antibody or by small interfering ribonucleic acids. 10 On this theme, results of a small RCT among 40 patients presenting for colon cancer surgery showed that serum levels of proangiogenic factors VEGF-C and transforming growth factor beta-1 increased significantly in the patients who received volatile-based anesthesia vs propofol-epidural anesthesia. Stem cells possess the ability to self-perpetuate and give rise to mature cells of a particular tissue through differentiation.…”

Section: Are Volatile Anesthetic Agents Safe To Use In Cancer Patients?mentioning

confidence: 99%

Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis?

Byrne

Levins

Buggy

2015

Can J Anesth/J Can Anesth

128

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“…Anesthesia has recently been linked with advancing cancer development through studies comparing regional vs. general anesthesia, with regional anesthesia being less pathogenic for various cancers [5–8]. Moreover, isoflurane, a widely used volatile anesthetic, has been found to enhance the malignant potential of renal [9], prostate [10] and ovarian cancer cells [11]. The mechanisms underlying the effects of isoflurane on cancer malignancy is under debate.…”

Section: Introductionmentioning

confidence: 99%

Isoflurane Promotes Non-Small Cell Lung Cancer Malignancy by Activating the Akt-Mammalian Target of Rapamycin (mTOR) Signaling Pathway

Zhang

Shao

2016

Med Sci Monit

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BackgroundLung cancer is one of the leading causes of cancer mortalities worldwide, and non-small cell lung cancer (NSCLC) accounts for the majority of all lung cancer cases. Surgery remains one of the front-line treatment options for NSCLC, but events within the perioperative period were found to affect cancer prognosis, such as anesthesia procedures. Isoflurane, a commonly used volatile anesthetic, enhances the malignant potential of renal, prostate, and ovarian cancer cells, but its effects on NSCLC development have not been previously reported.Material/MethodsCCK-8 and MTT cell proliferation assays were used to analyze NSCLC cell proliferation. Metastatic ability was examined by wound healing and transwell assays. We used Western blot analysis to study the mechanism of effect of Isoflurane in NSCLC development.ResultsWe demonstrated that isoflurane promotes proliferation, migration and invasiveness of NSCLC cells, as well as upregulation of the Akt-mTOR signaling pathway in NSCLC cells. Pharmacological inhibition of Akt-mTOR signaling abolished the ability of isoflurane to promote proliferation, migration, and invasion of NSCLC cells, indicating that isoflurane promotes NSCLC cell malignancy by activating the Akt-mTOR signaling pathway.ConclusionsIsoflurane promotes NSCLC proliferation, migration and invasion by activating the Akt-mTOR signaling pathway.

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Impact of isoflurane on malignant capability of ovarian cancer in vitro

Abstract: Our data indicate that isoflurane increases the malignant potential of ovarian cancer cells through the up-regulation of markers associated with the cell cycle, proliferation, and angiogenesis. This study warrants further investigations.

Cited by 102 publications

References 32 publications

Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases

Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases

Can anesthetic-analgesic technique during primary cancer surgery affect recurrence or metastasis?

Isoflurane Promotes Non-Small Cell Lung Cancer Malignancy by Activating the Akt-Mammalian Target of Rapamycin (mTOR) Signaling Pathway

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