Impact of intradialytic exercise on fatigue, biochemical and physiological parameters in patients on maintenance hemodialysis - A pilot study - Part 1

Ramai, P; Lobo, Diana

doi:10.1016/j.cegh.2022.101064

Cited by 4 publications

(9 citation statements)

References 4 publications

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“…Studies selected include 18 parallel arm RCTs, two randomized cross-over studies, seven nonrandomized studies that included an intervention and control group, and five single-group pre-post studies. 32 , 47 – 77 In total, 1817 individuals participated in these 32 studies, with sample sizes ranging from 6 to 174 participants (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…32 , 47 , 48 , 50 , 51 , 53 , 55 – 59 , 62 , 64 – 66 , 68 – 70 , 72 , 74 – 76 Four studies examined the effects of resistance exercise. 54 , 61 , 73 , 77 Five studies included both aerobic and resistance exercise. 49 , 52 , 60 , 63 , 67 One study did not state the type of exercise used in the intervention (Table 2 ).…”

Section: Resultsmentioning

confidence: 99%

“…49,53,60,68 Meta-analysis of these studies showed no statistically significant difference in the SD of normal R-R intervals during a 24-hour period (SD of N-N intervals [SDNN]) in the exercise group as compared with the control group (MD 16.05 ms; 95% CI, 214.60 to 46.70; I 2 599%; P , 0.001). By contrast, meta-analysis of three Cheng et al 61 Cooke et al 48 Fernandes et al 62 Graham−Brown et al 66 Greenwood et al 67 Huang et al 63 Koh et al 47 Kouidi et al 60 Kouidi et al 49 Liao et al 50 Martinez−Olmos et al 70 Momeni et al 32 Oliveira E Silva et al 64 Palar and Lobo 77 Paluchamy et al 65 Parsons et al 51 Pereira et al 68 Petraki et al 52 Reboredo et al 58 Toussaint et al 69 Random sequence generation (selection bias)…”

Section: Myocardial Structurementioning

confidence: 99%

“…67 Adverse Events, Adherence, and Study Attrition Only 19/32 studies reported adverse events. [47][48][49][50]52,53,58,60,61,[65][66][67][68][69][70]72,74,75,77 Across these studies, 248 adverse events occurred, with 135 (54.4%) occurring in the intervention groups and 113 (45.6%) in the control groups. Of the adverse events in the intervention group, only one was identified to be related to exercise.…”

Section: Cardiovascular Hospitalization and Mortalitymentioning

confidence: 99%

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Effect of Intradialytic Exercise on Cardiovascular Outcomes in Maintenance Hemodialysis: A Systematic Review and Meta-Analysis

Verrelli,

Sharma,

Alexiuk

et al. 2024

Kidney360

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Background: Cardiovascular disease is the leading cause of death among people with kidney failure on hemodialysis, for whom improving cardiovascular health is a research priority. Intradialytic myocardial stunning is common and associated with adverse cardiovascular events. Intradialytic exercise may mitigate intradialytic myocardial stunning and improve cardiovascular structure and function. This systematic review investigated the effect of intradialytic exercise on cardiovascular outcomes in adults undergoing maintenance hemodialysis (PROSPERO #CRD42018103118). Methods: Following PRISMA guidelines, we systematically searched MEDLINE, EMBASE, Cochrane CENTRAL, SportDiscus, and PEDro databases from 1960 until June 2022, for randomized and non-randomized studies investigating the effect of intradialytic exercise programs on objective cardiovascular outcomes, pre-specified as primary or secondary outcomes. The primary outcome was arterial resistance. Results: Of 10837 references identified, 32 met eligibility criteria. These studies investigated the effect of intradialytic exercise on arterial resistance (8 studies), blood pressure (20 studies), myocardial structure and function (7 studies), endothelial function (2 studies), sympathetic overactivity (9 studies), biomarkers of cardiac injury (3 studies), cardiovascular hospitalization and mortality (2 studies). Most studies used aerobic exercise as the intervention and usual care (no exercise) controls. Meta-analysis of intradialytic exercise versus usual care resulted in a statistically significant reduction in arterial resistance measured by pulse wave velocity (PWV) with mean difference -1.63 m/sec (95% CI -2.51, -0.75). Meta-analyses for diastolic blood pressure, left ventricular ejection fraction (LVEF), and low-frequency/high-frequency (LF/HF ratio) measure of heart rate variability also showed statistically significant improvements with exercise. There was no significant difference in change in systolic blood pressure, augmentation index, and left ventricular mass index between groups. Conclusion: Intradialytic exercise programming resulted in a clinically meaningful improvement to PWV, a component of arterial resistance. Sseveral physiologic measures of cardiovascular health, including diastolic blood pressure, LVEF and heart rate variability measured by the LF/HF ratio were also observed. The effects of intradialytic exercise on major adverse cardiovascular events remains uncertain.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Myocardial Structurementioning

confidence: 99%

Section: Cardiovascular Hospitalization and Mortalitymentioning

confidence: 99%

See 2 more Smart Citations

Effect of Intradialytic Exercise on Cardiovascular Outcomes in Maintenance Hemodialysis: A Systematic Review and Meta-Analysis

Verrelli,

Sharma,

Alexiuk

et al. 2024

Kidney360

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“…In terms of the effects of exercise on MHD patients, current studies mainly focused on biochemical and physiological parameters, 1 , 18 , 24 , 25 with limited attention on patient-reported outcomes, such as depression, anxiety, and fatigue. Considering the high prevalence and negative impacts of these patient-reported outcomes, 26 , 27 it is necessary to comprehensively assess the effects of exercise training on patient-reported outcomes in addition to objective parameters.…”

Section: Introductionmentioning

confidence: 99%

Does Intradialytic Group Exercise Programme Influence Patient-Reported Outcomes, Laboratory Parameters, and Anthropometric Parameters in Maintenance Hemodialysis Patients? A Single-Group Repeated-Measures Trial

Zhou¹,

Shi²,

Zhang³

et al. 2023

PPA

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Background Maintenance hemodialysis(MHD) patients often suffer from fatigue and are recommended to undertake physical activities. The optimal format of exercise rehabilitation for MHD patients remains uncertain despite demonstrated health benefits. This study aimed to evaluate the effectiveness of an intradialytic group exercise programme for MHD patients. Methods This was a single-centre, single-group repeated-measures design study. The 12-week, three times per-week intradialytic group exercise programme was conducted for around 30 min during the first 2 hours of each dialysis session. Patient-reported outcomes including fatigue, anxiety, depression and health-related quality of life, laboratory parameters including haemoglobin, albumin, pre-albumin and hypersensitive C-reactive protein, and anthropometric parameters including triceps skinfold thickness, mid-upper arm circumference, mid-arm muscle circumference and handgrip strength, were measured at baseline, immediately post-intervention and 12-weeks post-intervention. The repeated-measures analysis of variance and Friedman test were used to compare the parametric and non‐parametric data across time points, respectively. Results Ninety patients were enrolled and 75 completed. Participants reported significant improvements across time points in fatigue ( F = 10.19, p < 0.01), depression ( F = 19.20, p < 0.001), health-related quality of life ( F = 5.36, p = 0.006), haemoglobin ( F = 3.43, p = 0.047), albumin ( F = 4.42, p = 0.032), hypersensitive C-reactive protein ( χ 2 = 50.39, p < 0.001), pre-albumin ( χ 2 = 11.85, p = 0.003), triceps skinfold thickness ( F = 25.03, p < 0.001), mid-upper arm circumference ( F = 6.32, p = 0.005), mid-arm muscle circumference ( F = 4.89, p = 0.02), and handgrip strength ( F = 13.59, p < 0.001). Although the mean anxiety score tended to reduce, the difference across time points was nonsignificant ( F = 1.33, p = 0.27). Conclusion The findings suggested that the intradialytic group exercise programme could improve MHD patients’ fatigue, depression, health-related quality of life, nutritional status, and inflammation. Trial Registration Chinese Clinical Trial Registry ChiCTR2000034394 (04/07/2020).

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Intradialytic Exercise Sebagai Evidence Base Practice Untuk Mengurangi Kelelahan Pada Pasien Hemodialisis

Herabare,

Hudiyawati,

Purnama

2023

j. Keperawatan Tropis Papua

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Hemodialisa merupakan terapi yang dilakukan oleh pasien yang mengalami Chronic Kidney Disease (CKD). Kelelahan sering dialami oleh pasien CKD yang menjalani hemodialisa. Studi ini bertujuan untuk menerapkan evidence base practice yaitu terapi intradialytic exercise pada pasien hemodialisa. Desain studi ini menggunakan pre-post design. Studi ini menggunakan kuesioner FAS (Fatigue Assesment Scale) dengan interpretasi tingkat kelelahan normal (skor <22), ringan (skor 23-32), sedang (skor 33-34), berat (skor >35). Sampel penelitian berjumlah 3 responden. Penelitian dilakukan pada bulan September 2022 di unit Hemodialisa RS PKU Aisyiyah Boyolali. Terapi intradialytic exercise dilakukan pada 1 jam terakhir selama sesi hemodialisa dengan durasi waktu 10 menit dalam satu kali pertemuan. Hasil penelitian menunjukkan terdapat penurunan tingkat kelelahan pada responden setelah dilakukan terapi intradialytic exercise. Didapatkan data pada 2 responden saat pretest menunjukkan skor FAS dalam kategori berat yaitu dengan skor 36 dan 1 responden dalam kategori sedang yaitu 33. Saat posttest, ketiga responden mengalami penurunan skor FAS yaitu responden dalam kategori skor FAS berat menurun menjadi kategori sedang, sedangkan responden dengan kategori sedang mengalami penurunan menjadi kategori ringan. Penerapan evidence base practice berupa terapi intradialytic exercise yang dilakukan dapat menurunkan skor FAS yang menandakan adanya penurunan tingkat kelelahan pada pasien yang menjalani hemodialisis di RS PKU Aisyiyah Boyolali.

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Impact of intradialytic exercise on fatigue, biochemical and physiological parameters in patients on maintenance hemodialysis - A pilot study - Part 1

Cited by 4 publications

References 4 publications

Effect of Intradialytic Exercise on Cardiovascular Outcomes in Maintenance Hemodialysis: A Systematic Review and Meta-Analysis

Effect of Intradialytic Exercise on Cardiovascular Outcomes in Maintenance Hemodialysis: A Systematic Review and Meta-Analysis

Does Intradialytic Group Exercise Programme Influence Patient-Reported Outcomes, Laboratory Parameters, and Anthropometric Parameters in Maintenance Hemodialysis Patients? A Single-Group Repeated-Measures Trial

Intradialytic Exercise Sebagai Evidence Base Practice Untuk Mengurangi Kelelahan Pada Pasien Hemodialisis

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