Impact of intra-abdominal fat on surgical outcome and overall survival of patients with gastric cancer

Abstract

Obesity, as represented by BMI and VFA, may not be a poor prognostic factor in patients with gastric cancer.

Sarcopenia is highly prevalent in patients undergoing surgery for gastric cancer but not associated with worse outcomes

“…Furthermore, the amount of perirenal fat has been identified as a marker for intraabdominal fat and was associated with postoperative complications in elective colorectal surgery . In conjunction with results from this study another study in gastric cancer surgery patients also did not show differences in outcome in association with visceral adipose tissue .…”

Visceral adiposity and cancer survival: a review of imaging studies

“…As reported in a study of 46 patients with advanced ovarian cancer, the amount of VAT cross-sectional area was not related to PFS or OS, regardless of treatment type (Slaughter et al, 2014). A study in patients with gastric adenocarcinoma who received gastrectomy also reported no association between VAT cross-sectional area and post-surgical OS (Kim et al, 2014). Conversely, Li et al (2015) found that higher VAT, measured by intraperitoneal adipose tissue thickness, was associated with shorter OS (p = .003) and DFS (p < .001) in patients with locally advanced gastric cancer.…”

“…Among the studies hereby reviewed, VAT cross-sectional area was the most commonly used index, measured in 14 studies (Gaujoux et al, 2012;Guiu et al, 2010;Kaneko et al, 2015;Kang et al, 2012;Kim, Chin, Hwang, & Jun, 2014;Ladoire et al, 2011;Lee, Jeong et al, 2015;Lee, Murphy et al, 2015;Nault et al, 2015;Naya et al, 2010;Pecorelli et al, 2016;Slaughter et al, 2014;Steffens et al, 2011;Yamamoto et al, 2012). The distance or thickness between kidney and abdominal wall musculature at the level of renal vein has been used as a proxy for quantifying VAT in seven studies (Balentine, Enriquez et al, 2010;Clark et al, 2013;Li et al, 2015;Mathur et al, 2011;Miller et al, 2012;Papoulas et al, 2015;Pausch et al, 2012), by virtue of measurement efficiency and convenience.…”

Preoperative weight loss program involving a 20‐day very low‐calorie diet for obesity before laparoscopic gastrectomy for gastric cancer

“…Much of the research on surgical treatment of gastric cancer has focused on obesity in recent years (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Obesity is associated with increased blood loss, a prolonged operative time, a high rate of postoperative complications, and inadequate lymph node staging.…”