Impact of Interventional Therapy for Benign Prostatic Hyperplasia on Quality of Life and Sexual Function: A Prospective Study

Arai, Yoichi; Aoki, Yoshitaka; Okubo, Kazutoshi; Maéda, Hiroshi; Terada, Naoki; Matsuta, Yosuke; Maekawa, Shinya; Ogura, Keiji

doi:10.1016/s0022-5347(05)67142-x

Cited by 110 publications

(57 citation statements)

References 34 publications

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“…Table 5 shows the most important English language papers of interest. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Use of validated questionnaires is essential in sexual function assessment. Soderdhal et al 16 showed that a nonvalidated questionnaire may cause false reports of ED.…”

Section: Discussionmentioning

confidence: 99%

Effect of transurethral resection of the prostate on erectile function: a prospective comparative study

et al. 2009

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The effect of transurethral resection of the prostate (TURP) on erectile function is still controversial, and available evidence is conflicting. One of the possible mechanisms of post-TURP erectile dysfunction (ED) is direct thermal injury to the erectile nerves. The aim of this study was to investigate the effect of TURP on erectile function. Fifty patients undergoing TURP for obstructive benign prostatic hyperplasia (HBP) were prospectively included in the study, and 50 age-matched patients undergoing transurethral resection of the superficial bladder tumor were also prospectively included as a control group. All patients completed the international index of erectile function (IIEF-15), the international prostatic symptom score (IPSS) and the Hospital Anxiety and Depression Scale at inclusion in the study and then at the 3-and 6-month follow-up evaluation. Capsular perforations during TURP were prospectively reported by the operating surgeon. There was a significant improvement of erectile function in the TURP group despite the onset of ejaculation disorders in 70% of the patients. Improvement of erectile function was also found in the subgroup of patients with capsular perforation during TURP. Comparison with the control group showed that at preoperative evaluation, patients in the TURP group had more severe urinary symptoms and worse erectile function than did those of the control group. At the postoperative period, the IPSS score became comparable in the two groups, with major improvement of erectile function in the TURP group. We concluded that TURP improved erectile function in HBP patients with severe urinary symptoms. This improvement of erectile function was observed even in case of capsular perforation.

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Section: Discussionmentioning

confidence: 99%

Effect of transurethral resection of the prostate on erectile function: a prospective comparative study

et al. 2009

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“…A deterioration of sexual activity has been associated with the severity of ejaculatory dysfunction, particularly a decrease in volume or an absence of semen [48]. After EBRT, a lack of ejaculation was reported in 2-56% of patients [6,18,25].…”

Section: Ejaculatory and Other Sexual Dysfunctionsmentioning

confidence: 99%

Sexual function after external-beam radiotherapy for prostate cancer: What do we know?

Incrocci

2006

Critical Reviews in Oncology/Hematology

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“…29 Among 173 patients treated for BPH with a variety of interventional modalities, 45.5% of those who experienced loss of Sexual effects of medical therapy for benign prostatic hyperplasia DJ Carbone and S Hodges ejaculation or severe decrease in ejaculate volume reported that their sex life had deteriorated as a result of treatment. In contrast, only 18.6% of patients with a slight to moderate decrease in ejaculate volume and just 3.6% of men noting no change in ejaculate volume reported a deterioration in their sex life.…”

Section: Sexual Dysfunctionmentioning

confidence: 99%

Medical therapy for benign prostatic hyperplasia: sexual dysfunction and impact on quality of life

Carbone

Hodges

2003

Int J Impot Res

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Therapies for benign prostatic hyperplasia (BPH) may either improve or exacerbate sexual function with an ensuing impact on quality of life. Here we review a total of 73 papers on medical therapies for BPH with a focus on the effects of different pharmacological agents on sexual function. For example, certain a 1 -adrenergic receptor blockers may improve erectile function; however, ejaculatory dysfunction with one of these agents, tamsulosin, occurs at a rate of 4-18%, rising to 30% with long-term use. In addition, treatment with the 5a-reductase inhibitor finasteride is associated with problems of ejaculation (2.1-7.7%), erection (4.9-15.8%), and libido (3.1-5.4%). Such significant and undesirable complications in relation to sexual function produce a welldocumented negative impact on quality of life. Thus, optimal treatment for men with BPH requires the use of agents that demonstrate efficacy and safety with fewer sexual side effects.

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Impact of Interventional Therapy for Benign Prostatic Hyperplasia on Quality of Life and Sexual Function: A Prospective Study

Cited by 110 publications

References 34 publications

Effect of transurethral resection of the prostate on erectile function: a prospective comparative study

Effect of transurethral resection of the prostate on erectile function: a prospective comparative study

Sexual function after external-beam radiotherapy for prostate cancer: What do we know?

Medical therapy for benign prostatic hyperplasia: sexual dysfunction and impact on quality of life

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