Impact of Interleukin-17F Gene Polymorphisms in Outcome of Kidney Transplantation in Tunisian Recipients

Haouami, Youssra; Sfar, Imen; Dhaouadi, Tarak; Gargah, Tahar; Bacha, Mohamed Mongi; Bardi, R.; Abderrahim, E.; Goucha, R.; Ounissi, M.; Abdallah, T. Ben; Gorgi, Yousr

doi:10.1016/j.transproceed.2017.11.029

Cited by 4 publications

(2 citation statements)

References 24 publications

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“…Another paper from the group of Tunisia examines the effects of IL17F gene polymorphisms on kidney transplantation outcomes utilizing direct sequencing in 93 recipients of kidney transplants. 26 The IL17F SNPs under study did not show any statistically significant correlation with the onset of acute rejection. They concluded that the IL17F 7489A/G A allele may be associated with a decreased risk of acute rejection and improved graft survival, as in the present study allele T of IL17 -1507C/T (rs1889570) was associated with the better glomerulitis score (p = 0.041, OR = 0.30) and allele C of IL17-1165C/T (rs1266828) was associated with better glomerular sclerosis (p = 0.004, OR = 0.39) (Table 6).…”

Section: Discussionmentioning

confidence: 73%

Interleukin 17F Gene Polymorphisms and Chronic Kidney Allograft Failure

Liacini,

Olwi,

Tripathi

et al. 2023

Gene Expr

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Background and objectives: Polymorphisms of the interleukin (IL)-17 proinflammatory cytokine family (IL17A and IL17F) have been associated with kidney chronic allograft failure (CAF). To date, the impact of heritable differences in IL17F genes and CAF among kidney transplant patients from North America has not been reported. The objective of the study was to assess the association of five distinct polymorphisms in the IL17F gene with histopathological changes in chronic kidney allograft failure.Methods: Two hundred eighteen kidney transplant recipients were enrolled. Surveillance biopsies were performed to evaluate 11 distinct histological markers and the combined grade of interstitial fibrosis and tubular atrophy, 6 to 12 months posttransplant. Using direct sequencing, the IL17F polymorphisms (-1507C/T rs1889570, -1165A/G rs1266828, -5046C/T rs7771511, -6328G/A rs766748, and -7488A/G rs763780) were genotyped in the 10 healthy volunteer samples followed by all kidney transplant recipients were genotyped for five IL17F gene polymorphisms using polymerase chain reaction and sequence-specific primers. The association was evaluated using both univariate and multivariate logistic regression analysis. Results:We observed weak associations of TC genotype of IL17F-1165 (rs1266828) and allele of IL17F -1507C (rs1889570) with glomerular sclerosis and interstitial fibrosis and tubular atrophy (p = 0.017 and p = 0.03) respectively. Allele C of IL-17 -1165C/T (rs1266828) was associated with better glomerular sclerosis (p = 0.004, odds ratio = 0.39) score. Conclusions:Our findings demonstrate that IL17F SNPs were not associated with CAF and support our prior published results that production of pro-inflammatory cytokines is not a strong predictor of CAF.

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Section: Discussionmentioning

confidence: 73%

Interleukin 17F Gene Polymorphisms and Chronic Kidney Allograft Failure

Liacini,

Olwi,

Tripathi

et al. 2023

Gene Expr

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“…Studies on solid organ transplantation including bone marrow transplantation have highlighted the importance of polymorphisms of the IL-17F and IL-17A genes in the pathogenesis of allograft rejection (16). The association between IL-17A (17) and IL-17F gene polymorphisms with acute rejection (16) and the use of IL-17 serum levels as the primary marker of acute rejection (18,19) have been reported in kidney transplantation. IL-17F gene SNP 7489A/G is linked with graft failure (20).…”

Section: Zununi Vahed S Et Almentioning

confidence: 99%

IL-17 gene polymorphism (rs763780) in kidney recipients with post-transplant diabetes

et al. 2022

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Introduction: New-onset diabetes mellitus after transplantation (NODAT) is a common complication of organ transplantation, leading to allograft dysfunction. Genetic alterations of inflammatory cytokines have been reported to be associated with glucose homeostasis and diabetes. Objectives: This study evaluated the rs763780 polymorphism of IL-17F gene in transplant recipients with and without NODAT. Patients and Methods: The present retrospective study was conducted on ninety-one patients who have had a kidney transplant for at least three months. Patients were divided into two subgroups; recipients with NODAT (n=32) and kidney recipients without NODAT (n=59). After DNA extraction from patients’ blood samples, amplification and evaluation of specific polymorphism of the gene were performed using amplification refractory mutation system-polymerase chain reaction (ARMS-PCR). Clinical and demographic data of patients were collected. Results: The NODAT was detected in 81.3% (n=26) of TT genotype carriers, 12.5% of TC genotype carriers and 6.3% of CC genotype carriers. No statistically significant differences between the studied groups in the frequency of C and T alleles and the distribution of the abovementioned genotypes were detected (P≥0.721). In the NODAT group, graft rejection and age of patients were higher significantly (P≤0.017). Conclusion: No significant correlation between the incidence of diabetes and rs763780 polymorphism of IL-17F gene was observed.

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Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A

et al. 2019

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Background: Identifying kidney allograft recipients who are predisposed to acute rejection (AR) could allow for optimization of clinical treatment to avoid rejection and prolong graft survival. It has been hypothesized that part of this predisposition is caused by the inheritance of specific genetic variants. There are many publications reporting a statistically significant association between a genetic variant, usually in the form of a single nucleotide polymorphism (SNP), and AR. However, there are additional publications reporting a lack of this association when a different cohort of recipients is analyzed for the same SNP. Methods: In this report we attempted to validate 75 common genetic variants, which have been previously reported to be associated with AR, using a large kidney allograft recipient cohort of 2,390 European-Americans and 482 African Americans. Results: Of those variants tested, only one variant, rs2910164, which alters expression of the microRNA MIR146A, was found to exhibit a significant association within the African American cohort. Suggestive variants were found in the genes CTLA and TLR4. Discussion: Our results show that most variants previously reported to be associated with AR were not validated in our cohort. This shows the importance of validation when reporting associations with complex clinical outcomes such as AR. Additional work will need to be done to understand the role of MIR146A in the risk of AR in kidney allograft recipients.

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Impact of Interleukin-17F Gene Polymorphisms in Outcome of Kidney Transplantation in Tunisian Recipients

Cited by 4 publications

References 24 publications

Interleukin 17F Gene Polymorphisms and Chronic Kidney Allograft Failure

Interleukin 17F Gene Polymorphisms and Chronic Kidney Allograft Failure

IL-17 gene polymorphism (rs763780) in kidney recipients with post-transplant diabetes

Analysis of 75 Candidate SNPs Associated With Acute Rejection in Kidney Transplant Recipients: Validation of rs2910164 in MicroRNA MIR146A

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