Impact of interaction networks of B cells with other cells on tumorigenesis, progression and response to immunotherapy of renal cell carcinoma: A review

Abstract

Ample evidence indicates that the development and progression of renal cell carcinoma (RCC) are complex pathological processes involving interactions between tumor cells, immune cells and stromal components. Tumor infiltrated immune cells determine whether tumor advancement is promoted or inhibited. Among them, infiltrated B lymphocytes are present in all stages of RCC, playing a major role in determining tumor formation and advancement, as an essential part in the tumor microenvironment (TME). Although the advent of targeted and immune therapies has remarkably improved the survival of patients with advanced RCC, few cases can achieve complete response due to drug resistance. In this review article, we intend to summary the recent studies that outline the interaction networks of B cells with other cells, discuss the role of B cells in RCC development and progression, and assess their impact on RCC immunotherapy.

Integrated analysis of tertiary lymphoid structures and immune infiltration in ccRCC microenvironment revealed their clinical significances: a multicenter cohort study

“…51 We speculate that TLSs may affect immunological milieu by participating in recruiting, reactivating or reeducating effector T cells. 52 On the other hand, B cells within well-structured TLSs provide assistance for T cells and indicate issues of Open access synergetic function 53 while B cells within structured TLSs generate inhibitory factors that suppress the response of other immune cells. 15 We supposed that the different organization of immune infiltration-either dispersed or structured-resulted in the paradoxical properties of TLSs and TILs in ccRCC.…”

Predicting response of immunotherapy and targeted therapy and prognosis characteristics for renal clear cell carcinoma based on m1A methylation regulators

“…In addition, the level of MDSCs in patients with ccRCC increased and was positively correlated with poor prognosis 45 – 48 . However, the complexity of RCC tumor TME still exists 49 – 51 . For example, the results of NK cells are different from our conclusions.…”