Impact of intensive physical exercise and low-fat diet on collateral vessel formation in stable angina pectoris and angiographically confirmed coronary artery disease

Physical Activity in the Prevention and Treatment of Coronary Artery Disease

“…Belardinelli and coworkers were able to angiographically show enhanced collateral formation in a subset of patients with ischemic cardiomyopathy after 8 weeks of exercise training 89. However, despite reduced myocardial ischemia in thallium scintigraphy, the Heidelberg Regression Study failed to document any collateral growth using angiography in patients with stenotic CAD even after 1 year of intense exercise training 90. An increase in collateral formation could be shown in only patients in whom the progression of atherosclerotic lesions was detected, generating the hypothesis that myocardial ischemia is a necessary force driving collateral formation.…”

Exercício físico e disfunção endotelial

“…Among the components involved in this coronary circulation improvement are: endothelial functionf. sm 9,20,57 ; the velocity of production and oxidation of NO 6,58 ; microcirculation 9,20,57,59 ; the regression of atherosclerotic lesions 3,60,61 ; the neoformation of collateral vessels 3,60,61 ; the decrease in blood viscosity 18 and the increase in the diastolic perfusion time 59 .…”

Doença arterial coronariana, exercício físico e estresse oxidativo

“…Studies have demonstrated that physical exercise associated to cholesterol level control (hypofat diet) attenuates coronary injury development in the long term (four to six years of exercise), and may even lead to the regression of myocardial atherosclerotic plaque [69][70][71] . The phenomenon is seen as controversial by many, but what has been left out of the discussion is the possibility of improvement in myocardial perfusion [69][70][71] .…”

“…The phenomenon is seen as controversial by many, but what has been left out of the discussion is the possibility of improvement in myocardial perfusion [69][70][71] . On the other hand, the benefit of physical exercise in the short term is uncertain 72 .…”

“…However, myocardial perfusion studies have shown conflicting results on the scintigraphy of coronary patients who have been submitted to a regular exercise program. In the light of the facts presented, it can be observed that physical training effect on the formation of collateral vessels is still uncertain 63,68,69,73 . Generally speaking, human angiographic studies have found it difficult to find evidence of collateral circulation increase in coronary patients submitted to physical exercise -which may be explained by the fact that the exam cannot identify small size collateral arteries (< 100 µm).…”