Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

Carlier, Angela; Dols, Annemiek; Oudega, Mardien L.; Sienaert, Pascal; Bouckaert, Filip; Stek, Max L.; Eikelenboom, Piet; Exel, Eric van; Rhebergen, Didi

doi:10.1016/j.jagp.2021.09.003

The American Journal of Geriatric Psychiatry

2022

DOI: 10.1016/j.jagp.2021.09.003

|View full text |Cite

Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

Angela Carlier

Annemiek Dols

Mardien L. Oudega

et al.

Abstract: Should we treat older, patients with depression with white matter hyperintensities (WMH) with electroconvulsive therapy (ECT)? WMH, inflammation, depression and cognitive functioning are suggested to be intertwined. Hence, this study investigates whether the association between inflammation and cognition is different in patients with depression with or without WMH. Methods: Cognitive functioning was assessed using the Mini−Mental State Examination during and after a course of ECT in 77 older patients with depr… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2022

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 9 publications

(10 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

Zhang

Liu

et al. 2022

Neurochem Res

View full text Add to dashboard Cite

BackgroundPostoperative cognitive dysfunction is a common complication of the central nervous system after surgery, especially in elderly patients. White matter lesions cause cognitive impairment. Although stellate ganglion block (SGB) is an effective intervention for postoperative cognitive dysfunction, the exact mechanism remains unclear. The SIRT1 signaling pathway is involved in the process that SGB alleviates postoperative cognitive dysfunction. However, the underlying mechanisms that SGB improves postoperative cognitive dysfunction through SIRT1 in aged rats and its association with white matter lesion repair are yet to be elucidated. MethodsTo simulate a surgery-induced cognitive dysfunction-like condition, 20-month-old aged male Sprague-Dawley rat was subjected to splenectomy to induce cognitive impairment. Cognitive function was assessed by Morris water maze test. Western blotting was used to determine SIRT1 and NF-κB expression levels in the hippocampus and white matter under different circumstances. Immunohistochemistry was used to examine SIRT1 expression in white matter. The morphology of neural cells in white matter was observed by HE staining. NF-κB activity was measured by EMSA. The serum and white matter TNF-α, IL-6 and IL-10 levels were determined by ELISA. ResultsAfter splenectomy, the expression of SIRT1 in the rat hippocampus and white matter was dramatically decreased, NF-κB activity was enhanced, the levels of TNF-α, IL-6 and IL-10 in serum and white matter were increased, and rat showed signi cant cognitive impairment. After treatment with stellate ganglion block, activation of SIRT1 mediated by the SIRT1/NF-κB signaling pathway alleviated neuroin ammation, reversed white matter injury, and ameliorated surgery-induced cognitive dysfunction. ConclusionIn conclusion, we provide strong evidence to demonstrate that postoperative cognitive dysfunction in elderly patients is associated with white matter injury, and stellate ganglion block can improve postoperative cognitive impairment in the older by reversing white matter lesion by activating SIRT1.

show abstract

Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

Zhang

Liu

et al. 2022

Neurochem Res

View full text Add to dashboard Cite

show abstract

Causal effect of circulating cytokines on MRI markers of cerebral small vessel disease: A mendelian randomization study

Yang,

Yao,

Huo

2024

Cytokine

View full text Add to dashboard Cite

Peripheral blood inflammatory markers in depression: Response to electroconvulsive therapy and relationship with cognitive performance

Ryan¹,

McLoughlin²

2022

Psychiatry Research

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Impact of Inflammation on Cognitive Functioning After Electroconvulsive Therapy in Older Patients with Depression with and Without White Matter Hyperintensities

Cited by 3 publications

References 9 publications

Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

Stellate Ganglion Block Improves Postoperative Cognitive Dysfunction in aged rats by SIRT1-mediated White Matter Lesion Repair

Causal effect of circulating cytokines on MRI markers of cerebral small vessel disease: A mendelian randomization study

Peripheral blood inflammatory markers in depression: Response to electroconvulsive therapy and relationship with cognitive performance

Contact Info

Product

Resources

About