Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic

Duchesne, Élise; Dufresne, Sébastien S.; Dumont, Nicolas A.

doi:10.1093/ptj/pzx056

Cited by 44 publications

(27 citation statements)

References 79 publications

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“…The influence of augmented inflammatory and oxidative stress on training adaptations in muscle is still under debate, and some reports suggested that these factors could be positive (Niess et al, 2003). On the other hand, excessive reactive oxygen species and inflammatory response also lead to aggravated muscle fatigue and dysfunction (Zuo and Pannell, 2015; Duchesne et al, 2017). When the athletes perform RSH in addition to their daily training program, there would be several concerns for performance decrement because of increase in inflammatory and oxidative stress responses.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory, Oxidative Stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia

et al. 2019

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The present study was designed to determine the effects of repeated-sprint exercise in moderate hypoxia on inflammatory, muscle damage, oxidative stress, and angiogenic growth factor responses among athletes. Ten male college track and field sprinters [mean ± standard error (SE): age, 20.9 ± 0.1 years; height, 175.7 ± 1.9 cm; body weight, 67.3 ± 2.0 kg] performed two exercise trials in either hypoxia [HYPO; fraction of inspired oxygen (F i O 2 ), 14.5%] or normoxia (NOR; F i O 2 , 20.9%). The exercise consisted of three sets of 5 s × 6 s maximal sprints with 30 s rest periods between sprints and 10 min rest periods between sets. After completing the exercise, subjects remained in the chamber for 3 h under the prescribed oxygen concentration (hypoxia or normoxia). The average power output during exercise did not differ significantly between trials ( p = 0.17). Blood lactate concentrations after exercise were significantly higher in the HYPO trial than in the NOR trial ( p < 0.05). Plasma interleukin-6 concentrations increased significantly after exercise ( p < 0.01), but there was no significant difference between the two trials ( p = 0.07). Post-exercise plasma interleukin-1 receptor antagonist, serum myoglobin, serum lipid peroxidation, plasma vascular endothelial growth factor (VEGF), and urine 8-hydroxydeoxyguanosine concentrations did not differ significantly between the two trials ( p > 0.05). In conclusion, exercise-induced inflammatory, muscle damage, oxidative stress, and VEGF responses following repeated-sprint exercise were not different between hypoxia and normoxia.

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Section: Discussionmentioning

confidence: 99%

Inflammatory, Oxidative Stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia

et al. 2019

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“…Rapid increases in our understanding of the role of inflammation in health (25,26) and diet in inflammation (27,28) led to the development of the DII, which began in 2004. The first version of the DII debuted in 2009 (29).…”

Section: Background and History Of Developing The DIImentioning

confidence: 99%

Perspective: The Dietary Inflammatory Index (DII)—Lessons Learned, Improvements Made, and Future Directions

Hébert¹,

Shivappa²,

Wirth

et al. 2019

Advances in Nutrition

265

210

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The literature on the role of inflammation in health has grown exponentially over the past several decades. Paralleling this growth has been an equally intense focus on the role of diet in modulating inflammation, with a doubling in the size of the literature approximately every 4 y. The Dietary Inflammatory Index (DII) was developed to provide a quantitative means for assessing the role of diet in relation to health outcomes ranging from blood concentrations of inflammatory cytokines to chronic diseases. Based on literature from a variety of different study designs ranging from cell culture to observational and experimental studies in humans, the DII was designed to be universally applicable across all human studies with adequate dietary assessment. Over the past 4 y, the DII has been used in >200 studies and forms the basis for 12 meta-analyses. In the process of conducting this work, lessons were learned with regard to methodologic issues related to total energy and nutrient intake and energy and nutrient densities. Accordingly, refinements to the original algorithm have been made. In this article we discuss these improvements and observations that we made with regard to misuse and misinterpretation of the DII and provide suggestions for future developments.

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“…[ 25 , 32 , 33 ] These inflammatory cells and factors can affect the regeneration ability of satellite cells, leading to abnormal proliferation of skeletal muscle, changes in muscle fiber type and muscle atrophy. [ 34 ] However, in the process of COPD progression, patients often merged the diseases such as acute infection, metabolic disorders, whether and how to exclude this kind of patients in the application of NLR judgment muscle dysfunction, which will be study in further research in future.…”

Section: Discussionmentioning

confidence: 99%

The correlational study about neutrophil-to-lymphocyte ratio and exercise tolerance of chronic obstructive pulmonary disease patients

Yuan

Li²,

Yu³

et al. 2020

Medicine

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To study the relationship between neutrophil to lymphocyte ratio (NLR) and exercise tolerance of patients with chronic obstructive pulmonary disease (COPD). 235 patients with COPD were selected as the study subjects. Complete blood count, C reactive protein (CRP), pulmonary function tests, the 6-minute walk distance (6MWD), Modified Medical Respiratory Council, the COPD assessment test, and clinical COPD questionnaire were tested. Heart rate, oxygen saturation, and Borg scale were tested before or after 6MWD test. By the median of NLR, the subjects were divided into 2 groups, NLR ≥4.5 group and NLR <4.5 group. The white blood cell count (WBC), CRP and deoxygenation saturation in the NLR ≥4.5 group were higher than those in the NLR <4.5 group, while the age, body mass index (BMI), 6MWD, and heart rate variation were lower than those in the NLR <4.5 group. CRP, WBC, and deoxygenation saturation had positive effects on NLR, BMI, 6MWT, and heart rate variation had negative effects on NLR. The Pearson correlation analysis showed NLR was positively correlated with WBC, CRP, BMI index, 6MWT, and deoxygenation saturation, while it was negatively correlated with BMI and heart rate variation. NLR might associate with exercise tolerance and cardiorespiratory reserve of COPD patients, and could be used as an indicator of muscle function in COPD patients.

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Impact of Inflammation and Anti-inflammatory Modalities on Skeletal Muscle Healing: From Fundamental Research to the Clinic

Cited by 44 publications

References 79 publications

Inflammatory, Oxidative Stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia

Inflammatory, Oxidative Stress, and Angiogenic Growth Factor Responses to Repeated-Sprint Exercise in Hypoxia

Perspective: The Dietary Inflammatory Index (DII)—Lessons Learned, Improvements Made, and Future Directions

The correlational study about neutrophil-to-lymphocyte ratio and exercise tolerance of chronic obstructive pulmonary disease patients

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