Impact of infertility treatments on the health newborns

Perinatal outcome of singletons and twins after assisted conception: a systematic review of controlled studies

“…Preterm singletons (< 37 weeks) accounted for 5.8-15% and 1.4-10.5%, respectively (table 2). The relative risk in both the 12 matched1 4 – 10 12 19 21 22 and two non-matched23 25 studies showed a doubling of the risk of preterm birth after assisted conception.…”

“…Preterm twins differed widely in frequency from 18.8-60.0% and 20.0-52.4%, respectively. The relative risk was 1.07 (1.02 to 1.13) in the nine matched studies1 4 9 – 13 19 22 (table 3) and 0.99 (0.80 to 1.23) in the two non-matched studies (see web table D) 17 23…”

Health of children born after ovulation induction

“…Studies on perinatal health show that OI children are more often premature and/or of low birth weight, and/or were more often treated in the neonatal intensive care unit than naturally conceived children (4)(5)(6)(7)(8)(9); in all studies some kind of hormonal stimulation was used with or without IUI.…”

Twin pregnancy outcome among cases of spontaneous conception, intrauterine insemination, and in vitro fertilization/intracytoplasmic sperm injection

“…Many of the prior studies comparing spontaneous conception (SC) and ART have demonstrated that ARTs gave rise to detrimental effects for both mothers and neonates (2)(3)(4). In contrast to the classifications adopted in much of the prior research in this area, our study takes the step of classifying twins into three distinct groups: SC, intrauterine insemination (IUI), and in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET).…”