Impact of infectious complications on long-term survival following colorectal cancer surgery.

Mokdad, Ali H.; Hirsch, Hannah; Nassour, Ibrahim; Borja, Nicholas; Balch, Glen C.; Polanco, Patricio M.

doi:10.1200/jco.2016.34.4_suppl.531

Cited by 1 publication

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“…A systematic review and meta-analysis including 21 studies published between 1965 and 2009 found that anastomotic leak after colorectal cancer surgery is associated with increased local recurrence and cancer-specific mortality but not distant recurrence [30]. Further studies have shown a correlation between postoperative infectious complications and worse overall survival [31][32][33]. A study of 12,075 patients using the Veteran's Affairs cancer registry found that complications were associated with decreased overall survival and that this was primarily driven by infectious complications [32].…”

Section: Discussionmentioning

confidence: 99%

The Association between Pathologic Complete Response after Neoadjuvant Chemoradiotherapy and Postoperative Complications

et al. 2021

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Introduction: With growing interest in the watch-and-wait strategy, the benefits of avoiding surgery and its complications must be weighed against possible recurrence and need for salvage surgery. However, the relationship between pathologic complete response (pCR) and postoperative complications has not been well established. Methods: This is a retrospective study using the National Surgical Quality Improvement Program Proctectomy and Colectomy Procedure-Targeted databases from 2016 to 2018. The association between pCR and major complications, sepsis, anastomotic leak or organ space infection, return to the operating room, or septic shock was analyzed. Results: A total of 3,878 rectal cancer patients who received chemotherapy or radiation therapy within 90 days of surgery were included in this study. The pCR rate was 12.8%. There was no statistically significant association between pCR and major complications (adjusted odds ratio (OR) = 0.48, p = 0.12) after risk adjustment. Those with pCR had no statistically significant association with anastomotic leak or organ space infection, return to the operating room, or septic shock but had significantly lower odds of sepsis (adjusted OR = 0.42, p = 0.03). Conclusions: It is reassuring that pCR is not associated with postoperative complications and that those with pCR are less likely to have postoperative sepsis after risk adjustment since postoperative sepsis after rectal surgery has been associated with poorer oncologic outcomes.

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