Impact of infection in hospitalized cirrhotic patients in a university hospital

Abstract

Background: Infection increases the morbidity and mortality in liver cirrhosis patients. The aim of this study was to investigate the impact of infection related to survival and risk factors for death in adult patients with liver cirrhosis in a university hospital. Methods: In a retrospective cohort study of Brazilian hospitalized cirrhotic patients, medical records data were analysed, and all patients who have had one or more confirmed bacterial infection during admission were selected for the study. Also, some data as biochemical investigation, Child score, MELD estimation, and evolution and death event were included.

Infections in Cirrhotics: Types, Microbiological Spectrum and Risk Factors—5-Year Cohort Study

“…In this study mean age of patients with infection was 49 year ± 13 SD years which is different from earlier studies where mean age was 54.4 and 69.5 years respectively [27] [28]. The frequency of infection among male (42.95%) and female cirrhotics (41.97%) were different in this study from previous study [29]. An earlier study showed slightly higher frequency among males 57% as compared to females 43% [27].…”

Prevalence of Bacterial Infection in Patients with Chronic Hepatitis C Treated and not Treated with Interferon

“…These finding were closely in agreement with that reported by Fried (2002). On the contrary, Ferreira et al (2012) reported that respiratory tract infection represent 15 % among his study population .Our study and other studies provided evidence that gram negative bacilli and staphylococci were the most common bacterial species implicated in respiratory tract infection (Cheruvattath and Balan 2007). Spontaneous bacterial peritonitis (SBP) was a frequent and a serious complication that occurs in 10-30% of patients with cirrhosis and ascites (Garcia-Tsao, 2005 andNavasa et al,1997) which mainly was caused by enteric bacteria particularly Escherichia coli (Bert et al, 2005 andPark et al, 2007) while in our study SBP represent only 8 % (12 of 149 cases) of bacterial infections.…”

“…Marincu et al (2010) reported that 77.3% of acute bacterial infection occurred during therapy with interferon and ribavirin was associated with neutropenia .In our study, neutropenia represented 94.5 % of patients who were treated with interferon and rabavirin (IR) and they are having bacterial infection. Ferreira et al (2012) and Mattos et al (2003) reported that urinary tract infection represented 31.8% between cirrhotic patients .This was in agreement with our results which showed that urinary tract infection was 32.2% among the study population.…”