Impact of increased paternal age on neonatal outcomes in very-low-birth-weight infants

Kim, Sol; Kim, Minsoo; Oh, Moon-Yeon; Seo, Yumi; Yum, Sook Kyung

doi:10.1080/14767058.2023.2257836

Cited by 2 publications

(1 citation statement)

References 42 publications

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“…Interestingly, the negative impacts of older paternal age on live birth outcomes are somewhat mitigated when the female partner is under 35, suggesting that younger maternal age can buffer the adverse effects of aged sperm [128]. Furthermore, advanced paternal age is linked to a higher risk of adverse birth outcomes such as low birth weight, preterm birth, and stillbirth, which indirectly affect the live birth rate by compromising pregnancy viability [154,155].…”

Section: Effect Of Paternal Age On Live Birth Ratementioning

confidence: 99%

Advanced Paternal Age in Focus: Unraveling Its Influence on Assisted Reproductive Technology Outcomes

Kaltsas,

Zikopoulos,

Vrachnis

et al. 2024

JCM

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As global demographics shift toward increasing paternal age, the realm of assisted reproductive technologies (ARTs), particularly in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), faces new challenges and opportunities. This study provides a comprehensive exploration of the implications of advanced paternal age on ART outcomes. Background research highlights the social, cultural, and economic factors driving men toward later fatherhood, with a focus on the impact of delayed paternity on reproductive outcomes. Methods involve a thorough review of existing literature, centering on changes in testicular function, semen quality, and genetic and epigenetic shifts associated with advancing age. Study results point to intricate associations between the father’s age and ART outcomes, with older age being linked to diminished semen quality, potential genetic risks, and varied impacts on embryo quality, implantation rates, and birth outcomes. The conclusions drawn from the current study suggest that while advanced paternal age presents certain risks and challenges, understanding and mitigating these through strategies such as sperm cryopreservation, lifestyle modifications, and preimplantation genetic testing can optimize ART outcomes. Future research directions are identified to further comprehend the epigenetic mechanisms and long-term effects of the older father on offspring health. This study underscores the need for a comprehensive approach in navigating the intricacies of delayed fatherhood within the context of ART, aiming for the best possible outcomes for couples and their children.

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Section: Effect Of Paternal Age On Live Birth Ratementioning

confidence: 99%