Impact of increased inflammation biomarkers on periprocedural myocardial infarction in patients undergoing elective percutaneous coronary intervention: a cohort study

Abstract

Background: The fact that each inflammatory indicator has a forecasting capacity on the occurrence of periprocedural myocardial infarction (PMI) has a controversial existence. The purpose of this study was to explore the role of inflammation biological indicators on PMI in a group of patients undergoing selective percutaneous coronary intervention (PCI). Methods: The study was carried out both in a retrospective and prospective manner in 7,413 and 1,189 subjects, respectively. In the retrospective cohort study, the association between inflammation biomarkers and PMI was assessed by univariate and multivariate logistic regression. WBC, CRP, and NLR were distributed using k-means clustering into a virtual variable "Inflammatory Trend", and multivariate logistic regression and subgroup analysis were performed. In the prospective cohort study, the endpoints were PMI, cardiovascular death or cardiac arrest. The chi-square test was performed to calculate the relative risk (RR). Results: In the retrospective cohort study, except WBC, CRP, NLR and virtual variable "Inflammatory trend" were independent risk factors for PMI. The subgroup analysis revealed that CRP can serve as the most stable predictor. In the prospective cohort study, WBC (RR =1.134, P=0.416) has no effect on the incidence of PMI. However, an elevation in the incidence of PMI was observed with an increase of NLR (RR =1.354, P=0.041) and CRP (RR =1.412, P=0.025). Conclusions: In patients with elective PCI for single-vessel lesions, high CRP increases the risk for PMI.The increase of NLR was an independent risk factor for PMI, especially for patients with hypertension and under the age of 70. WBC has no influence on the occurrence of PMI.

Biomarkers of inflammation and endothelial dysfunction in elderly patients with myocardial infarction, hypertension and frailty

“…Близкие к нашим данным параметры СРБ выявлены у пациентов 60-74 лет с ИМ в ближайшие 48 ч после выполнения чрескожного коронарного вмешательства в ретроспективном (СРБ=1,76±1,72 мг/л) и проспективном исследованиях (1,78±1,88 мг/л) [17]. Исследование, направленное на изучение связи между увеличением СРБ и частотой ИМ у пациентов с плановым чрескожным коронарным вмешательством в ретроспективном и проспективном этапах, представило доказательства того, что повышенные уровни СРБ и других биомаркеров воспаления были значимыми факторами, влияющими на возникновение ИМ и особенно после корректировки факторов, связанных с процедурными характеристиками.…”

Neutrophil Counts, Neutrophil-to-Lymphocyte Ratio, and Systemic Inflammatory Response Index (SIRI) Predict Mortality after Off-Pump Coronary Artery Bypass Surgery

“…Complex coronary artery disease can be treated by either coronary percutaneous or surgical revascularization [ 9 , 10 , 11 ]. The periprocedural inflammatory overreaction is one of the possible factors that indicate a worse long-term prognosis [ 12 , 13 , 14 , 15 , 16 ].…”

Evaluation of C-reactive protein as predictor of adverse prognosis in acute myocardial infarction after percutaneous coronary intervention: A systematic review and meta-analysis from 18,715 individuals

“…Despite advances in the therapies for coronary artery disease, such as percutaneous coronary intervention (PCI) which has saved a lot of lives since its application ( 1 ), myocardial infarction is still the main cause of morbidity and mortality among all cardiovascular diseases worldwide ( 2 , 3 ). For patients with acute myocardial infarction (AMI) undergoing PCI, inflammatory response plays a pivotal role in the whole pathophysiological process.…”