Impact of immunopathy and coagulopathy on multi-organ failure and mortality in a lethal porcine model of uncontrolled hemorrhagic shock
Milomir O. Simovic,
James A Bynum,
Bin Liu
et al.
Abstract:Background: Uncontrolled hemorrhage is a major preventable cause of death in patients with trauma. However, the majority of large animal models of hemorrhage have utilized controlled hemorrhage rather than uncontrolled hemorrhage to investigate the impact of immunopathy and coagulopathy on multi-organ failure (MOF) and mortality. This study evaluates these alterations in a severe porcine-controlled and uncontrolled hemorrhagic shock (HS) model.
Methods: Anesthetized female swine underwent controlled hemo… Show more
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