Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells

Gayet, Rémi; Michaud, Eva; Nicoli, Francesco; Chanut, Blandine; Paul, None Mireille; Rochereau, Nicolas; Guillon, Christophe; Hé, Zhiguo; Papagno, Laura; Bioley, Gilles; Corthésy, Blaise; Paul, Stéphane

doi:10.1002/eji.201948177

Cited by 19 publications

(12 citation statements)

References 55 publications

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“…iga comprises different subclasses (iga1/iga2) and/or isoforms (monomeric, dimeric/secretory). While the iga circulating form is predominantly monomeric iga1 (85%) and considered as an anti-inflammatory isotype, the dimeric/secretory iga exhibits both pro-and anti-inflammatory actions (31).…”

Section: Discussionmentioning

confidence: 99%

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

et al. 2021

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Given the current outbreak of coronavirus disease 2019 and the development and implementation of mass vaccination, data are being obtained by analyzing vaccination campaigns. in the present study, 69 healthcare workers who were exposed to patients with severe acute respiratory syndrome coronavirus-2 were monitored for specific immunoglobulin (Ig)G and IgA levels at different time periods. Prior to vaccination, after the first round of vaccination at 21 days (when the second dose of vaccine was administrated) and 24 days after the second round of vaccination, with an mrna-based vaccine. The basal igG and iga levels in previously infected subjects and non-infected subjects notably differed. Vaccination increased the igG and iga levels after the first dose in most subjects from both groups, the levels of which further increased following the second round of vaccination. The associations between igG and iga levels following the first and second rounds of vaccination demonstrated that in the entire vaccination group, regardless of prior exposure to the infectious agent, the increment and levels of igG and iga were similar. Thus, the levels upon vaccination were statistically similar irrespective of the starting base line prior to vaccination. in the present study, seroconversion was achieved in all subjects following the second round of vaccination, with similar antibodies levels.

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Section: Discussionmentioning

confidence: 99%

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

et al. 2021

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“…It is possible that this process was more stimulated after weaning because the gene set related to multivesicular endocytic recycling was one of the most enriched (First genes: RILP, TMEM50B, LYST ). In the context of JPPs it is also possible that mucosal antigens are transported by IgA to activate local DCs and prime T cells 21 . Finally, the need to recycle relevant quantities of MHC I molecules could explain the 1st ranking of PCSK9 , involved in their complexation and additional lysosomal degradation 22 .…”

Section: Discussionmentioning

confidence: 99%

Weaning differentially affects the maturation of piglet peripheral blood and jejunal Peyer’s patches

Correa

Luise

Bosi

et al. 2022

Sci Rep

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The study aimed to assess how the post-weaning condition changes piglet peripheral blood (PB) and jejunal Peyer’s patches (JPPs) as compared to the suckling period, and how these changes are associated with intestinal microbiota evolution. Sixteen pigs were slaughtered and sampled for PB, JPPs and jejunal content (JC) at weaning (26 days) or at 12 days fed on a pre-starter diet. The PB and JPP transcriptomes were analysed using mRNA-seq. The Gene Set Enrichment Analysis was used to demonstrate enriched gene clusters, depending on sampling time. Jejunal microbiota was profiled using 16S rRNA gene sequencing. Post-weaning JPPs were enriched for processes related to the activation of IFN-γ and major histocompatibility complex (MHC) class I antigen processing which clustered with the reduced abundance of the Weisella genus and Faecalibacterium prausnitzii in JC. The post-weaning microbiome differed from that seen in just-weaned pigs. For just-weaned PB, the enrichment of genes related to hemoglobin and the iron metabolism indicated the greater presence of reticulocytes and immature erythrocytes. The JPP genes involved in the I MHC and IFN-γ activations were markers of the post-weaning phase. Several genes attributable to reticulocyte and erythrocyte maturation could be interesting for testing the iron nutrition of piglets.

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“…Curiously, mice lack FcαRI as well as clear FCRL3 and FCRL4 homologs, representing limitations to murine disease models. In addition, the novel IgA receptor DC‐SIGN most strongly binds monomeric IgA, while also binding dimeric IgA and SIgA less efficiently 48 . Thus, neither FcαRI nor DC‐SIGN has the degree of IgA specificity displayed by FCRL3 and FCRL4.…”

Section: Fcrl3 and Fcrl4 Are Respective Siga And Dimeric Iga Receptorsmentioning

confidence: 99%

Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity

Tolnay

2021

Journal of Leukocyte Biology

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Members of the Fc receptor‐like (FCRL) family modulate B and T cell responses, yet their functional roles remain enigmatic. Nevertheless, FCRL3 promoter polymorphism that alters gene expression has been associated with autoimmune disease risk, indicating physiologic importance. Providing essential functional context, human FCRL3, FCRL4, and FCRL5 have recently been identified as secretory IgA (SIgA), dimeric IgA, and IgG receptors, respectively, revealing novel ways lymphocytes can interact with antibodies. FCRL3 and FCRL4 are able to distinguish the mucosal and systemic origin of IgA‐containing immune complexes, respectively, with clear implications in guiding mucosal responses. SIgA can signal mucosal breach through FCRL3, driving the functional plasticity of regulatory T cells toward inflammatory to help control invading pathogens. Conversely, recognition of dimeric IgA by FCRL4 on memory B cells located in mucosa‐associated lymphoid tissues could promote tolerance to commensals. Memory B cells that accumulate under conditions of chronic antigen presence frequently express FCRL4 and FCRL5, and antibody ligands could provide functional feedback to the cells. FCRL5 apparently recognizes the age of the IgG molecule, using deamidation as a molecular clock, conceivably playing regulatory roles in chronic antibody responses. A framework of FCRL3, FCRL4, and FCRL5 operating as sensors of antibodies in immune complexes is proposed. Sensing the spatial origin and age of immune complexes can shape lymphocyte functional attributes and inform their participation in mucosal immune responses. The potential contributions of FCRL3 and SIgA to the pathogenesis of autoimmune diseases are discussed.

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Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells

Cited by 19 publications

References 55 publications

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

COVID‑19 vaccination and IgG and IgA antibody dynamics in healthcare workers

Weaning differentially affects the maturation of piglet peripheral blood and jejunal Peyer’s patches

Lymphocytes sense antibodies through human FCRL proteins: Emerging roles in mucosal immunity

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