Impact ofLycium barbarumarabinogalactan on the fecal metabolome in a DSS-induced chronic colitis mouse model

Abstract

Gut microbes and untargeted/targeted metabolomics were combined to comprehensively understand the therapeutic effect and the underlying mechanism of Lycium barbarum arabinogalactan (LBP-3) in DSS-induced colitis mice.

Ascophyllum nodosum polysaccharide regulates gut microbiota metabolites to protect against colonic inflammation in mice

“…31 In addition, a recent study has demonstrated that the content of tryptophan in mice with DSS-induced colitis was lower than normal. 24,32 The present study suggests that tryptophan was positive with IL-10 expression. Deprivation of tryptophan would also induce the progression and exacerbation of colonic inflammation in patients.…”

“…5 The gut microbiota could interact with polysaccharides to produce metabolites that have an important role in maintaining intestinal homeostasis. 4,24 However, the metabolic changes in gut microbiota regulated by the supplementation of ANP are still unknown. Therefore,…”

“…5 The gut microbiota could interact with polysaccharides to produce metabolites that have an important role in maintaining intestinal homeostasis. 4,24 However, the metabolic changes in gut microbiota regulated by the supplementation of ANP are still unknown. Therefore, untargeted and targeted LC-MS metabolomics were performed to investigate the metabolites and metabolic pathways altered by ANP in vitro and in vivo , which could also explore the possible mechanism of ANP against CiMe-induced colitis.…”

“…Parameters for chromatography separation, data analysis and mass spectrometer were identical to our previous report. 24…”

Effects of Lycium barbarum Polysaccharides on Immunity and Metabolic Syndrome Associated with the Modulation of Gut Microbiota: A Review

“…In addition, our latest research showed that arabinogalactan-type LBP-3 could reverse the levels of certain specific amino acids (e.g., tryptophan, phenylalanine, lysine, glutamine, homoserine, and leucine) and organic acids, (e.g., kynurenine, 2-isopropylmalic acid, ascorbic acid, gluconic acid, ( S )-2-hydroxyglutarate, and taurine) disturbed by DSS induction [ 104 ]. Moreover, pathway analysis indicated that the pentose phosphate pathway, phenylalanine, tyrosine and tryptophan biosynthesis, and phenylalanine metabolism were also altered by LBP-3 [ 104 ]. Additionally, LPS is also considered an intestinal bacterial metabolite, and its level was dramatically reduced by LBPs in HFD/streptozotocin (STZ)-induced diabetes in rats and mice [ 101 , 105 ].…”