Impact of<i>Helicobacter pylori</i>infection on ghrelin and various neuroendocrine hormones in plasma

Isomoto, Hajime; Ueno, Hiroaki; Nishi, Yuki; Wen, Chun-Yang; Nakazato, Masamitsu; Kohno, Shigeru

doi:10.3748/wjg.v11.i11.1644

Cited by 48 publications

(46 citation statements)

References 28 publications

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“…Although ghrelin is a potent GH secretagogue, there have been conflicting data on the relationship between ghrelin levels and IGF-I or GH levels (44,(61)(62)(63)(64)(65)(66). Our data showed a negative association between ghrelin and IGF-I, but this correlation did not persist after adjustment for age, gender, and BMI.…”

Section: Discussioncontrasting

confidence: 42%

“…Overall, this is of interest because most studies on the effects of H. pylori infection on gastric or circulating ghrelin dynamics in adults have included in Table 4 Changes in body mass index (BMI), SDS-BMI, fat and lean mass, ghrelin, and leptin at 6 and 12 months in Helicobacter pylori-positive children with early and late eradication of the organism, and H. pylori-negative children. the H. pylori-negative group subjects with no gastric inflammation or an unspecified histological status of the gastric mucosa (26,27,30,44,45). Therefore, further investigation is clearly required to understand the role of gastric and circulating ghrelin in children as well as in adults with gastritis due to any cause, including H. pylori.…”

Section: Discussionmentioning

confidence: 99%

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Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Pacifico¹,

Anania²,

Osborn³

et al. 2008

European Journal of Endocrinology

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Background: Helicobacter pylori, and the chronic gastric inflammation that it causes, may compromise the function and survival of ghrelin-producing cells, resulting in a decrease of circulating ghrelin levels. This finding raises the possibility that the infection might affect growth in children by reducing the ghrelin production. Aims: To determine baseline circulating levels of ghrelin and leptin in prepubertal children with and without H. pylori infection and to evaluate the long-term effects of H. pylori eradication on circulating levels of ghrelin and leptin as well as on body composition. Patients: Thirty children with H. pylori-associated gastritis, 35 children with H. pylori-negative gastric mucosa, and 20 healthy controls were studied. Results: At baseline, while leptin levels were significantly lower in H. pylori-positive patients, ghrelin concentrations did not differ among the three study groups. However, a significant inverse correlation between ghrelin concentrations and histological severity of gastritis was found. Eradication of the organism was associated with a progressive decrease in ghrelin concentrations over baseline at both 6-and 12-month follow-ups. SDS-body mass index (BMI), lean and fat mass, as well as leptin concentrations, significantly increased over baseline at both follow-ups. Conclusions: In prepubertal children, serum ghrelin concentrations are inversely related to the severity of H. pylori-associated gastritis. In these youngsters, long-term eradication of H. pylori infection is associated with a significant increase in BMI, lean and fat mass along with a significant decrease in circulating ghrelin levels and an increase in leptin levels.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussionmentioning

confidence: 99%

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Pacifico¹,

Anania²,

Osborn³

et al. 2008

European Journal of Endocrinology

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“…4 Distribution of (a) height-for-age Z-score (HAZ), (b) weight-for-age Z-score (WAZ) and (c) body mass index-forage Z-score (BMIZ) among the study group in relation to infection with Helicobacter pylori controversy exists over the relationship between ghrelin release and H. pylori infection. Decreased plasma levels of circulating ghrelin have been reported in H. pyloripositive individuals compared with non-infected subjects (194.2 6 90.2 vs. 250.4 6 84.1 fmol ml -1 respectively, P , 0.05) 36 , and following H. pylori eradication, ghrelin levels increase significantly 36 . Decreased ghrelin concentrations are also associated with higher levels of leptin 36 , a hormone responsible for suppressing appetite, regulating energy intake and modulating energy expenditure, and a reduction in the secretion of growth hormone 37 .…”

Section: Discussionmentioning

confidence: 92%

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Mohammad¹,

Hussein²,

Coward

et al. 2008

Public Health Nutr.

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Objective: The study aim was to assess the prevalence of Helicobacter pylori infection in Egyptian schoolchildren and its effect on growth parameters. Design: A cross-sectional population-based study was conducted among 286 schoolchildren (168 boys and 118 girls), with a mean age of 11.04 6 0.19 years, to determine the prevalence of H. pylori. The presence of the bacterium was assessed using the [ 13 C]urea breath test. Relevant personal and socio-economic data on risk factors for infection were collected. Height and weight were analysed in relation to H. pylori infection. Results: The overall prevalence of H. pylori infection was 72.38%. Attending school in a socially deprived area and residing in an overcrowded home were the major risk factors for infection. Differences between infected and non-infected children were significant with regard to body weight and height (weight: 39.5 6 1.0 vs. 44.6 6 1.8 kg, P 5 0.05; height: 139.9 6 1.3 vs. 144.2 6 2.1 cm; P 5 0.009). The number of children (both boys and girls) falling below the 5th percentile of height-for-age was significantly higher in infected than non-infected children (P 5 001), similarly for Z-scores for height-for-age below -2.0 (P 5 0.003). Conclusion:The results demonstrate not only that the prevalence of H. pylori infection is extremely high among Egyptian schoolchildren, but also that the adverse effects of the infection reach far beyond the stomach. Evidence of the burden of infection on growth failure is presented.

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“…7,25 However, gastric leptin values were elevated in H. pyloriinfected individuals and decreased following eradication. 26 Plasma ghrelin levels were lower in H. pylori positive individuals in some studies 19,27,28 although two small studies differed as to whether levels altered following eradication. 25,27 Recently, H. pylori eradication increased weight and decreased plasma ghrelin levels (but increased gastric levels) in men participating in a Japanese gastric cancer surveillance programme.…”

Section: Discussionmentioning

confidence: 99%

“…Participants who tested positive for H. pylori with the UBT (using a standard test meal of citric acid and orange juice with a cutoff of Cd 13 3.5 per cm 3 ) 13 were randomised either to H. pylori eradication therapy (ranitidine bismuth citrate 400 mg and clarithromycin 500 mg twice daily for 2 weeks) or to placebo. Randomisation was stratified by gender and age (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)30-39, 40-49 and 50-59 years). Staff independent of the study prepared the randomisation sequence, which was generated by computer with a block size of 10.…”

Section: Methodsmentioning

confidence: 99%

Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled study

Lane

Murray

Harvey

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

100

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Impact ofHelicobacter pyloriinfection on ghrelin and various neuroendocrine hormones in plasma

Cited by 48 publications

References 28 publications

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Long-term effects of Helicobacter pylori eradication on circulating ghrelin and leptin concentrations and body composition in prepubertal children

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Randomised clinical trial: Helicobacter pylori eradication is associated with a significantly increased body mass index in a placebo-controlled study

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