Impact of<i>EXO1</i>Polymorphism in Susceptibility to Colorectal Cancer

Haghighi, Mahdi Montazer; Taleghani, Mohammad Yaghoob; Mohebbi, Seyed Reza; Vahedi, Mohsen; Fatemi, Seyed Reza; Zali, Narges; Shemirani, Atena Irani; Zali, Mohammad Reza

doi:10.1089/gtmb.2010.0034

Cited by 18 publications

(12 citation statements)

References 18 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many previous studies have investigated the association between the Pro757Leu polymorphism and cancer risk. Studies performed by Yamamoto et al, 15 Kim et al, 17 and Haghighi et al 25 revealed that the Leu/Leu genotype is associated with reduced risk of colorectal cancer in Asians, which concurred with our results of subgroup analysis on ethnicity and cancer types. However, the results of some studies differ from our own results, 19 – 22 which may be attributed to the limitation of sample size.…”

Section: Discussionsupporting

confidence: 92%

“…Of these, six were studies of Caucasians, nine were studies of Asians, and one was a study of mixed population, while four were population based and ten were hospital based. In addition, there were three lung cancer studies, 16 , 19 , 21 four colorectal cancer studies, 15 , 17 , 25 , 29 two cervical cancer studies, 24 , 28 and seven others studies including glioblastoma, 18 gastric cancer, 20 oral cancer, 22 breast cancer, 23 melanoma, 26 hepatocellular cancer, 27 and pancreatic cancer. 30 Table 2 lists the genotype distribution and allele frequency of Exo1 polymorphism among cancer cases and controls and the P -value of the HWE in the controls.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis

Chen¹,

Zheng²,

Zhong³

et al. 2016

OTT

View full text Add to dashboard Cite

To date, the results of studies exploring the relation between exonuclease 1 (Exo1) polymorphisms and cancer risks have differed. In this study, we performed a meta-analysis to investigate the effect of the three most extensively studied Exo1 polymorphisms (Pro757Leu, Glu589Lys, and Glu670Gly) on cancer susceptibility. The related studies published before August 5, 2015, were collected by searching the PubMed and EMBASE databases. We found 16 publications containing studies that were eligible for our study, including 10 studies for Pro757Leu polymorphism (4,093 cases and 3,834 controls), 12 studies for Glu589Lys polymorphism (6,479 cases and 6,550 controls), and 7 studies for Glu670Gly polymorphism (3,700 cases and 3,496 controls). Pooled odds ratios and 95% confidence intervals were used to assess the strength of the associations, and all the statistical analyses were calculated using the software program STATA version 12.0. Our results revealed that the Pro757Leu polymorphism was significantly associated with a reduced cancer risk, whereas an inverse association was found for the Glu589Lys polymorphism. Furthermore, subgroup analysis of smoking status indicated that the Glu589Lys polymorphism was significantly associated with an increased cancer risk in smokers, but not in nonsmokers. However, no evidence was found for an association between the Glu670Gly polymorphism and cancer risk. In conclusion, this meta-analysis suggests that the Pro757Leu polymorphism may provide protective effects against cancer, while the Glu589Lys polymorphism may be a risk factor for cancer. Moreover, the Glu670Gly polymorphism may have no influence on cancer susceptibility. In the future, large-scaled and well-designed studies are needed to achieve a more precise and comprehensive result.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis

Chen¹,

Zheng²,

Zhong³

et al. 2016

OTT

View full text Add to dashboard Cite

show abstract

“…16 Haghighi et al investigated a relationship of L757P polymorphism of the EXO1 gene with susceptibility to CRC in a population of Iran and confirmed that patients with the Leu/Leu genotype have a decreased risk for CRC (adjusted OR, 0.192; 95% CI, 0.040Y0.921), especially when the Pro/Leu and Pro/Pro genotypes were combined and considered as the reference. 17 This conclusion was similar to that of Yamamoto et al In addition, Jin et al 19 found that the polymorphism of K589E is associated with the risk of lung cancer in a Chinese population. Unconditional logistic regression analysis showed that 589Lys allele significantly increased the risk for lung cancer (OR, 1.41; 95% CI, 1.09Y1.84).…”

Section: Discussionsupporting

confidence: 83%

“…9 The differences in the genome depend on the level of variation caused by SNPs, including mutation, transversion, insertion, and deletion forms based on single-base DNA sequence. The deficiency of MMR system results in numerous gene mutations that lead to the development of multiple tumors 10Y12 such as breast, 13 oral, 14 gastric, 15 colorectal, 16,17 pancreatic, 18 and lung cancers. 19,20 Therefore, it is rational to suspect that some genetic variants of DNA MMR gene like exonuclease I (EXO1) might be involved in the development of cervical carcinoma.…”

mentioning

confidence: 99%

A Single Nucleotide Polymorphism in EXO1 Gene Is Associated With Cervical Cancer Susceptibility in Chinese Patients

Luo

Hong

Xiong

et al. 2012

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

show abstract

“…The Leu allele of another EXO1 polymorphism (Leu757Pro, rs9350) may also be associated with decreased risk for colorectal cancer [164].…”

Section: Exo1 Genementioning

confidence: 99%

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Chakarov¹,

Petkova²,

Russev³

2014

Biodiscovery

View full text Add to dashboard Cite

The first part of this paper reviews the major achievements in the rapidly expanding field of research of individual capacity for repair of genotoxic damage. The issues of individual repair capacity are addressed from mul ple sides, analyzing the impact of the heritable components of the capacity for detoxifica on of genotoxic compounds, on the one hand (determining the risk for occurrence of DNA damage) and of the capacity for repair of DNA damage (when it has already occurred), on the other hand. The role of the capacity for repair of damage to DNA is discussed in the cons tu on of the risk for development of disease (mainly cancer, but also other common diseases and condi ons, such as diabetes, atherosclerosis and cardiovascular disease) and as a major factor in the outcomes of genotoxic therapies (eligibility for therapy with specific agents, risk for severe adverse effects, post-therapeu c survival rates, etc.). The paper contains an extensive list of biomarkers (mainly DNA polymorphisms, but also enzymes and other phenotypic markers, such as markers of the capacity for self-renewal of cell popula ons) that may be poten ally applicable in the assessment of the risk for carcinogenesis or for development other types of human disease.The second part of the paper provides a brief glimpse of the basic methodology used to obtain experimental results in assessment of the efficiency of DNA repair in living cells for research and diagnos c purposes.Cita on: Chakarov S, Petkova R, Russev GCh. Individual capacity for detoxifica on of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair.

show abstract

Impact ofEXO1Polymorphism in Susceptibility to Colorectal Cancer

Abstract: Our results provide evidence diagnosing that the Leu/Leu genotype of EXO1 showed an inverse association with CRC. In addition, despite other investigations, we could define a significant association between the Leu allele and CRC (p = 0.001).

Cited by 18 publications

References 18 publications

Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis

Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis

A Single Nucleotide Polymorphism in EXO1 Gene Is Associated With Cervical Cancer Susceptibility in Chinese Patients

Individual capacity for detoxification of genotoxic compounds and repair of DNA damage. Commonly used methods for assessment of capacity for DNA repair

Contact Info

Product

Resources

About