Impact of hyperuricemia on clinical outcomes after percutaneous coronary intervention for in-stent restenosis

Joo, Hyung Joon; Jeong, Han Saem; Kook, Hyungdon; Lee, Seung Hun; Park, Jae Hyoung; Hong, Soon Jun; Yu, Cheol Woong; Lim, Do Sum

doi:10.1186/s12872-018-0840-2

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…Even though we observed an increased incidence of elevated uric acid levels in patients with ISR, the correlation was not statistically significant. However, the value of uric acid correlated well with the ISR incidence, in accordance with the literature data ( 17 , 18 ).…”

Section: Discussionsupporting

confidence: 91%

Risk factors associated with intra‑stent restenosis after percutaneous coronary intervention

et al. 2021

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The present study aimed to explore the correlations between clinical, biological, imagistic and procedural factors with the risk of intra-stent restenosis (ISR) in coronary artery disease (CAD) patients after percutaneous coronary intervention (PCI). An observational cross-sectional study was conducted in a high-volume PCI center over a period of 2 years. A total of 235 consecutive patients diagnosed with angina or acute coronary syndrome treated by PCI were included in the study. Diagnosis of ISR was documented by coronary angiography in patients with suggestive coronary symptoms and ischemic changes in non-invasive or invasive paraclinical investigations. Thus, they were assigned to two groups: With or without ISR. All patients underwent clinical and laboratory examination, providing clinical and paraclinical variables that could be considered risk factors for ISR. Current smokers [risk ratio (RR)=1.63; 95% confidence interval (95% CI): 1.25-2.13], arterial hypertension (RR=1.86; 95% CI: 1.41-2.45), diabetes (RR=1.83; 95% CI: 1.42-2.36), high C-reactive protein (CRP) levels (RR=1.44; 95% CI: 0.93-2.24), chronic kidney disease (CKD) (RR=1.90; 95% CI: 1.53-2.36) and thrombolysis in myocardial infarction (TIMI) score were found to have a significant role in estimating the risk for ISR. Moreover, the ISR group (119 patients) presented with a lower stent inflation pressure when compared to the control group (116 patients) (14.47 vs. 16.14 mmHg, P=0.004). An increased mean stent diameter used for PCI was not associated with a high ISR incidence (P=0.810) as well as complex coronary treated lesions with longer stents (mean length of 24.98 mm in patients without ISR vs. 25.22 mm in patients with ISR; P=0.311). There was an estimated two times higher risk (RR=2.13; 95% CI: 1.17-3.88) concerning multi-stenting and restenosis degree >70%. To conclude, smoking, hypertension, diabetes mellitus, high CRP levels, CKD, TIMI score, stent type, low pressure for stent implantation and multi-stenting were found to be associated with ISR in patients following PCI. Therefore, a close follow-up should be targeted in such patients.

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Section: Discussionsupporting

confidence: 91%

Risk factors associated with intra‑stent restenosis after percutaneous coronary intervention

et al. 2021

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“…Addition of hyperuricemia to GRACE increased the risk of 38% of the total participants. (Gaubert et al, 2018) 37 Endothelial dysfunction with reactive hyperemia (RH) and severity of atherosclerosis Non-invasive peripheral arterial tonometry (PAT) and angiography The uric acid level had a significant relationship with Reactive Hyperemia Index/RHI (β= -0.17, p<0.001), and the uric acid level was associated with the Gensini score and SYNTAX score (p<0.001) (Joo et al, 2018) 27 Major adverse event (MAE): the cause of all mortality, non-fatal myocardial infarction, and revascularization. Angiography Uric acid was not an independent predictor of MAE (HR 1.110; 95% CI 0.980-1.257; p= 0.100) (Karabağ et al, 2019) 39 SYNTAX score II (SII) and long-term mortality Angiography Uric acid and SYNTAX independent predictors of long-term mortality (HR 1.24, 95% CI 1.046-1.482, p= 0.014; HR 1.042, 95% CI 1.007-1.079, p= 0.018) …”

Section: Resultsmentioning

confidence: 99%

“… 21 , 22 , 24 , 26 , 28 , 31 , 32 , 35 , 36 , 39 Several studies, however, call the evidence for a correlation into question, claiming that there is no significant relationship between uric acid levels and CHD mortality prognosis. 19 , 27 Hospital records or death certificates are used to determine a person’s mortality prognosis.…”

Section: Resultsmentioning

confidence: 99%

The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence

Maulana¹,

Nuraeni²,

Nugraha³

2022

JMDH

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Background This study sought to determine whether uric acid levels have a relationship with and can potentially be used as a prognosis for coronary heart disease (CHD) biomarkers using a scoping review. Methods This study was conducted following Arksey and O’Malley’s scoping review framework. It was reported as obeying the Preferred Reporting Item for Systematic Review and Meta-analysis for Scoping Review (PRISMA-ScR). The subject was extensively searched for in PubMed, CINAHL, and ScienceDirect. The inclusion criteria in the study were that the sources were journal articles written in English and were available in full text. The age of the subject in the item is the elderly population to capture the relationship between uric acid levels and the prognosis of CHD. The publication time limit was 2010 to 2020. The study was analyzed using thematic analysis. Results We identified 592 studies in our initial search, and 21 studies with a cohort design were included in this study’s analysis. The majority of the evidence suggests an independent correlation with a poor prognosis of CHD in the elderly population. The prognosis of gout includes the prognosis of clinical outcome, severity, and mortality, all of which influence the prognosis value, which becomes a marker. Conclusion Uric acid levels have been identified as a potential biomarker for poor CHD prognosis. Nurses and other healthcare workers should learn how to control poor CHD prognosis.

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“…In the late stages of arterial hypertension, however, hyperuricemia is connected mainly with kidney micro circulation injury, and its direct association with increased BP values is less clear. The well-documented association between hyperuricemia and ischemic heart disease may be attributed to the aforementioned pathomechanism, as well as to increased platelet aggregation and in-stent restenosis [40].…”

Section: Hyperuricemia and Cardiovascular Diseasementioning

confidence: 99%

Pathophysiology of hyperuricemia and its clinical significance – a narrative review

Skoczyńska¹,

Chowaniec²,

Szymczak³

et al. 2020

Reumatologia

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Hyperuricemia, i.e. increased serum uric acid (UA) concentration, is a common problem in clinical practice. While there are clear guidelines concerning management of symptomatic hyperuricemia in acute conditions such as gout, urolithiasis or acute urate nephropathy, less is known about their secondary prevention. Moreover, despite the ongoing debate on the role of UA in the pathogenesis of chronic kidney disease, hypertension, cardiovascular disease and heart failure, the management of asymptomatic hyperuricemia in patients with these chronic conditions is still mainly up to physicians' judgement. Individual considerations should always be taken into account when prescribing urate-lowering therapy. In this narrative review study, we attempt to present current trends concerning treatment of patients with either symptomatic or asymptomatic hyperuricemia in the light of the available knowledge on the role of hyperuricemia in the development of gout, renal, cardiovascular and other diseases.

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Impact of hyperuricemia on clinical outcomes after percutaneous coronary intervention for in-stent restenosis

Cited by 6 publications

References 41 publications

Risk factors associated with intra‑stent restenosis after percutaneous coronary intervention

Risk factors associated with intra‑stent restenosis after percutaneous coronary intervention

The Potential of Prognostic Biomarkers of Uric Acid Levels in Coronary Heart Disease Among Aged Population: A Scoping Systematic Review of the Latest Cohort Evidence

Pathophysiology of hyperuricemia and its clinical significance – a narrative review

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