Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels

Kitagami, Masayuki; Yasuda, Ryuta; Toma, Naoki; Shiba, Masato; Nampei, Mai; Yamamoto, Yoko; Nakatsuka, Yoshinari; Sakaida, Hiroshi; Suzuki, Hitomi

doi:10.1016/j.jstrokecerebrovasdis.2017.04.010

Cited by 15 publications

(21 citation statements)

References 26 publications

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“…However, even among patients with substantial reductions in LDL-C levels, residual cerebrovascular risk persists. High levels of TGs constitute an independent risk factor for the progression of carotid stenosis in patients with normal LDL-C levels [14]. Moreover, a study found that a history of a lipid disorder had the strongest association with the severity of intracranial stenosis [21].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study confirmed that SUA is a risk factor for intracranial artery stenosis [13]. In addition, data from several studies suggest that triglycerides (TGs) are a risk factor for cerebrovascular diseases, including carotid stenosis and intracranial artery stenosis [14, 15]. Overall, SUA and TGs are extremely important in the pathological and physiological processes of cerebrovascular diseases.…”

Section: Introductionmentioning

confidence: 98%

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Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Feng

et al. 2019

BioMed Research International

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Background. Evidence regarding the relationship between serum uric acid and triglycerides is limited. Therefore, the specific objective of this study was to investigate whether serum uric acid was independently related to triglycerides in Chinese patients with newly diagnosed moyamoya disease after adjusting for other covariates. Methods. The present study was a cross-sectional study. A total of 261 Chinese patients with newly diagnosed moyamoya disease were recruited from a hospital in China from 24 March 2013 to 24 December 2018. The independent variable and the dependent variable were serum uric acid measured at baseline and triglycerides, respectively. The covariates involved in this study included age, sex, body mass index, smoking status, and alcohol consumption. Results. The average age of the 227 selected participants was 47.5 ± 12.6 years old, and approximately 48.5% of them were male. The results of the fully adjusted linear regression showed that serum uric acid (10 μmol/L) was positively associated with triglycerides (mmol/L) after adjusting for confounders (β 0.048, 95% CI 0.032, 0.064). Conclusions. In patients with moyamoya disease, there seemed to be a positive association between serum uric acid and triglycerides.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Feng

et al. 2019

BioMed Research International

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“…Several studies investigated if TG can be a risk factor for the progression of CA stenosis [60,62] . In patients with diabetes, the CA atherosclerosis progression tended to occur more frequently when fasting TG levels were higher [60] .…”

Section: Dyslipidemia and Ca Stenosismentioning

confidence: 99%

“…In patients with diabetes, the CA atherosclerosis progression tended to occur more frequently when fasting TG levels were higher [60] . Recently, Kitagami et al [62] reported that a higher level of TG was an independent risk factor for the progression of CA atherosclerosis in patients with moderate to severe CA stenosis who were treated with CA stenting (CAS), CEA, or other treatments under well-controlled LDL-C levels. The findings suggest that to control TG levels at least within the normal limits is an important management strategy for CA stenosis [62] .…”

Section: Dyslipidemia and Ca Stenosismentioning

confidence: 99%

“…Recently, Kitagami et al [62] reported that a higher level of TG was an independent risk factor for the progression of CA atherosclerosis in patients with moderate to severe CA stenosis who were treated with CA stenting (CAS), CEA, or other treatments under well-controlled LDL-C levels. The findings suggest that to control TG levels at least within the normal limits is an important management strategy for CA stenosis [62] . However, to our knowledge, no studies have revealed the relationships between the degree of changes in TG levels and the rate of CA IMT progression.…”

Section: Dyslipidemia and Ca Stenosismentioning

confidence: 99%

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Dyslipidemia and atherosclerotic carotid artery stenosis

Miura¹,

Suzuki²

2019

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Carotid artery atherosclerosis or stenosis is frequently present at the carotid bifurcation or the internal carotid artery, accounting for at least 20% of all ischemic strokes. High levels of serum total cholesterol and low-density lipoprotein cholesterol are established risk factors for genesis and progression of atherosclerotic lesions through various mechanisms. In addition, accumulating evidence has shown that a high level of triglyceride is associated with increased atherosclerosis risks. The so-called "vulnerable plaque" with a large lipid core, thin fibrous cap and intra-plaque hemorrhage tends to cause subsequent thromboembolic ischemic events. Statins are known not only to lower serum cholesterol levels but also to promote plaque stabilization via pleiotropic effects such as reducing subclinical systemic inflammation, endothelial activation, leukocyte intra-plaque infiltration, and increasing intimal smooth muscle cell migration. This article discusses the mechanisms of atherosclerosis formation induced by dyslipidemia and the role of lipid-lowering agents including statins in patients with symptomatic and asymptomatic atherosclerotic carotid artery stenosis.

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Effects of Dyslipidemia on the Cerebral Vessels

Lee

Kang

2021

Stroke Revisited: Dyslipidemia in Stroke

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Impact of Hypertriglyceridemia on Carotid Stenosis Progression under Normal Low-Density Lipoprotein Cholesterol Levels

Cited by 15 publications

References 26 publications

Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Serum Uric Acid and Triglycerides in Chinese Patients with Newly Diagnosed Moyamoya Disease: A Cross-Sectional Study

Dyslipidemia and atherosclerotic carotid artery stenosis

Effects of Dyslipidemia on the Cerebral Vessels

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