Impact of hypertonic saline nebulisation combined with oscillatory positive expiratory pressure on sputum expectoration and related symptoms in cystic fibrosis: a randomised crossover trial

Miguel-Pagola, Marta San; Reychler, Grégory; Iranzo, Maria dels Àngels Cebrià i; Gómez-Romero, Marta; Díaz-Gutiérrez, Fernando; Herrero-Cortina, Beatriz

doi:10.1016/j.physio.2019.11.001

Cited by 12 publications

(31 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Seven of the 10 studies included assessed lung function through FEV 1 . 23 , 25 – 30 Five of the studies also examined other types of lung function measures. 22 , 23 , 26 , 29 , 30 Sputum viscoelasticity, sputum solids content, and ease of expectoration were examined in two studies.…”

Section: Resultsmentioning

confidence: 99%

“… 21 , 22 Four studies evaluated the amount of sputum. 25 , 28 – 30 LCI was measured in two other clinical trials. 24 , 26 The feeling of congestion in the chest was analyzed in three trials 22 , 24 , 29 and two of these recorded the number of coughs.…”

Section: Resultsmentioning

confidence: 99%

“… 24 , 26 The feeling of congestion in the chest was analyzed in three trials 22 , 24 , 29 and two of these recorded the number of coughs. 22 , 24 Half of the studies evaluated the well-being of the participants using different instruments: SF-36, 23 CRQ, 23 VAS scale, 25 CFQ-R, 27 , 29 LCQ, 27 , 28 and CASA-Q. 28 Four trials measured tolerance to therapy.…”

Section: Resultsmentioning

confidence: 99%

“… 22 , 24 Half of the studies evaluated the well-being of the participants using different instruments: SF-36, 23 CRQ, 23 VAS scale, 25 CFQ-R, 27 , 29 LCQ, 27 , 28 and CASA-Q. 28 Four trials measured tolerance to therapy. 23 , 26 , 28 , 29 Blood oxygen was recorded in three studies.…”

Section: Resultsmentioning

confidence: 99%

“… 28 Four trials measured tolerance to therapy. 23 , 26 , 28 , 29 Blood oxygen was recorded in three studies. 25 , 26 , 30 Participants’ preference for the techniques to which they were subjected was examined in four articles.…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Effectiveness of positive expiratory pressure on patients over 16 years of age with cystic fibrosis: systematic review and meta-analysis

Rocamora-Pérez

Benzo-Iglesias

Valverde-Martínez

et al. 2022

Ther Adv Respir Dis

View full text Add to dashboard Cite

Introduction: Cystic fibrosis (CF) is an autosomal recessive disease that involves the cells that produce mucus and sweat, affecting many organs, especially the lungs. Positive expiratory pressure (PEP) devices generate a pressure opposite to that exerted by the airways during expiration, thus improving mucociliary clearance. Objectives: To evaluate the efficacy of PEP devices as a resource to facilitate the mucus removal and other outcomes in people with CF, as well as the possible adverse effects derived from their use. Material and Method: A systematic review and meta-analysis was conducted according to PRISMA standards. The descriptors were ‘cystic fibrosis’, ‘PEP’, and ‘physiotherapy and/or physical therapy’. The search was performed in four databases: PubMed, PEDro, and Web of Science and Scopus, in July 2021. The inclusion criteria were randomized controlled trials (RCTs) over the last 10 years. The methodological quality of the studies was analyzed and meta-analysis was performed with Review Manager software. Results: Ten RCTs met the objectives and criteria, with a total of 274 participants. The trials score a moderate methodological quality on the PEDro scale. No clear results were obtained on whether PEP provides better lung function than other breathing techniques (such as airway clearance); but it does achieve a higher rate of lung clearance than physical exercise. Conclusions: PEP is more effective than usual care or no intervention, although there is not enough evidence to confirm that PEP achieves improvements in forced expiratory volume in the first second (FEV1) compared with other techniques. It is a safe technique, without adverse effects.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Effectiveness of positive expiratory pressure on patients over 16 years of age with cystic fibrosis: systematic review and meta-analysis

Rocamora-Pérez

Benzo-Iglesias

Valverde-Martínez

et al. 2022

Ther Adv Respir Dis

View full text Add to dashboard Cite

show abstract

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis

Warnock

Gates

2023

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

Nebulised hypertonic saline for cystic fibrosis

Wark

McDonald

2018

Cochrane Database of Systematic Reviews

115

View full text Add to dashboard Cite

Background Impaired mucociliary clearance characterises lung disease in cystic fibrosis (CF). Hypertonic saline enhances mucociliary clearance and may lessen the destructive inflammatory process in the airways. This is an update of a previously published review. Objectives To investigate efficacy and tolerability of treatment with nebulised hypertonic saline on people with CF compared to placebo and or other treatments that enhance mucociliary clearance. Search methods We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Cystic Fibrosis Trials Register, comprising references identified from comprehensive electronic database searches, handsearches of relevant journals and abstract books of conference proceedings. We also searched ongoing trials databases. Date of most recent searches: 08 August 2018. Selection criteria Randomised and quasi-randomised controlled trials assessing hypertonic saline compared to placebo or other mucolytic therapy, for any duration or dose regimen in people with CF (any age or disease severity). Data collection and analysis Two authors independently reviewed all identified trials and data, and assessed trial quality. The quality of the evidence was assessed using GRADE. Main results A total of 17 trials (966 participants, aged 4 months to 63 years) were included; 19 trials were excluded, three trials are ongoing and 16 are awaiting classification. We judged 14 of the 17 included trials to have a high risk of bias due to participants ability to discern the taste of the solutions. Hypertonic saline 3% to 7% versus placebo At four weeks, we found very low-quality evidence from three placebo-controlled trials (n = 225) that hypertonic saline (3% to 7%, 10 mL twice-daily) increased the mean change from baseline of the forced expiratory volume at one second (FEV 1) (% predicted) 1 Nebulised hypertonic saline for cystic fibrosis (Review)

show abstract

Impact of hypertonic saline nebulisation combined with oscillatory positive expiratory pressure on sputum expectoration and related symptoms in cystic fibrosis: a randomised crossover trial

Cited by 12 publications

References 26 publications

Effectiveness of positive expiratory pressure on patients over 16 years of age with cystic fibrosis: systematic review and meta-analysis

Effectiveness of positive expiratory pressure on patients over 16 years of age with cystic fibrosis: systematic review and meta-analysis

Airway clearance techniques compared to no airway clearance techniques for cystic fibrosis

Nebulised hypertonic saline for cystic fibrosis

Contact Info

Product

Resources

About