Impact of Hyperkalemia in Heart Failure and Reduced Ejection Fraction: A Retrospective Study

López‐López, Andrea; Franco‐Gutiérrez, Raúl; Pérez-Pérez, Alberto J.; Regueiro‐Abel, Margarita; Elices-Teja, Juliana; Abou-Jokh-Casas, C; González‐Juanatey, Carlos

doi:10.3390/jcm12103595

Cited by 1 publication

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“…In addition to being a marker of disease severity, hyperkalemia can directly affect cardiac function. Elevated serum potassium levels alter the resting membrane potential of cardiomyocytes, leading to impaired conduction velocity and decreased excitability [ 20 , 21 ]. This can result in arrhythmias, heart blocks, and reduced myocardial contractility [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Baseline Serum Potassium and 1-Year Readmission in Pediatric Patients with Heart Failure: A Retrospective Cohort Study

Han,

Huang,

et al. 2024

Children

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Pediatric heart failure (HF) is associated with high readmission rates, but the optimal serum potassium range for this population remains unclear. In this single-center retrospective cohort study, 180 pediatric patients hospitalized for HF between January 2016 and January 2022 were stratified into low-potassium (<3.7 mmol/L), middle-potassium (3.7–4.7 mmol/L), and high-potassium (≥4.7 mmol/L) groups based on the distribution of potassium levels in the study population. The primary outcome was readmission for HF within 1 year of discharge. Cox regression and restricted cubic spline models were used to assess the association between potassium levels and 1-year HF readmission rates. Notably, 38.9% of patients underwent 1 or more 1-year readmissions for HF within 1 year. The high-potassium group had a significantly higher readmission frequency than the middle-potassium group. In multivariate Cox regression models, potassium levels of ≥4.7 mmol/L were independently associated with increased 1-year readmission risk. A J-shaped relationship was observed between baseline potassium levels and 1-year readmission risk, with the lowest risk at 4.1 mmol/L. In pediatric patients with HF, a serum potassium level ≥ 4.7 mmol/L was independently associated with increased 1-year readmission risk. Maintaining potassium levels within a narrow range may improve outcomes in this population.

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Section: Discussionmentioning

confidence: 99%