Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance

Zawada, Adam M.; Lang, Thomas; Ottillinger, Bertram; Kırçelli, Fatih; Stauss-Grabo, Manuela; Kennedy, James P.

doi:10.3390/membranes12100932

Cited by 15 publications

(35 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, development of facile and accurate methods to determine (separately) the native and denatured albumin concentration, in the context of in vivo tests, would greatly aid these efforts. The suggested specific research targets can be pursued in the context of significant ongoing efforts aiming to improve biocompatibility of materials towards optimisation of HC modes [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

On the total albumin losses during haemocatharsis

Karabelas

2024

J Artif Organs

View full text Add to dashboard Cite

Excessive albumin losses during HC (haemocatharsis) are considered a potential cause of hypoalbuminemia—a key risk factor for mortality. This review on total albumin losses considers albumin “leaking” into the dialysate and losses due to protein/membrane interactions (i.e. adsorption, “secondary membrane formation” and denaturation). The former are fairly easy to determine, usually varying at the level of ~ 2 g to ~ 7 g albumin loss per session. Such values, commonly accepted as representative of the total albumin losses, are often quoted as limits/standards of permissible albumin loss per session. On albumin mass lost due to adsorption/deposition, which is the result of complicated interactions and rather difficult to determine, scant in vivo data exist and there is great uncertainty and confusion regarding their magnitude; this is possibly responsible for neglecting their contribution to the total losses at present. Yet, many relevant in vitro studies suggest that losses of albumin due to protein/membrane interactions are likely comparable to (or even greater than) those due to leaking, particularly in the currently favoured high-convection HDF (haemodiafiltration) treatment. Therefore, it is emphasised that top research priority should be given to resolve these issues, primarily by developing appropriate/facile in vivo test-methods and related analytical techniques.

show abstract

Section: Discussionmentioning

confidence: 99%

On the total albumin losses during haemocatharsis

Karabelas

2024

J Artif Organs

View full text Add to dashboard Cite

show abstract

“…Additionally, due to reducing hemofilter performance and a decline in flux, protein adsorption on the membrane also affects its hemocompatibility. Upon the adsorption of coagulation factors onto the artificial surface, the proteins undergo conformational changes or denaturation, which promotes thrombus formation [ 1 ].…”

Section: Characteristics Of Membranes For Crrtmentioning

confidence: 99%

“…In that condition, like with any other submerged filtration membrane, the hemofilter loses its properties over time and use which results in a rapid decline in flux and makes it impossible to accurately assess the effectiveness of applied therapy. The most significant reason for this loss is the formation of a so-called second membrane when a biofilm layer is formed within minutes of contact with aqueous solutions [ 1 ]. The main factor of fouling in low-pressure membranes such as MF and UF is organic matter composed of proteins, polysaccharides and bacteria cells suspended in feed [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood

Wójtowicz,

Stodolak-Zych

2023

Membranes

View full text Add to dashboard Cite

An extracorporeal blood purification method called continuous renal replacement therapy uses a porous hollow-fiber polymeric membrane that is exposed to prolonged contact with blood. In that condition, like with any other submerged filtration membrane, the hemofilter loses its properties over time and use resulting in a rapid decline in flux. The most significant reason for this loss is the formation of a biofilm. Protein, blood cells and bacterial cells attach to the membrane surface in complex and fluctuating processes. Anticoagulation allows for longer patency of vascular access and a longer lifespan of the membrane. Other preventive measures include the modification of the membrane itself. In this article, we focused on the role of nanoadditives in the mitigation of biofouling. Nanoparticles such as graphene, carbon nanotubes, and silica effectively change surface properties towards more hydrophilic, affect pore size and distribution, decrease protein adsorption and damage bacteria cells. As a result, membranes modified with nanoparticles show better flow parameters, longer lifespan and increased hemocompatibility.

show abstract

“…PVP occupies a special place among a wide range of water-soluble polymers due to its unique properties-surface activity, high hydrophilicity, a wide range of solubility, and a pronounced tendency to complex formation [43]. In addition, PVP is widely used in membrane technologies [40,[44][45][46][47]. Films formed on the basis of polyamide/PVP solutions in formic acid are characterized by hydrophilic properties and increased strength characteristics [23].…”

Section: Introductionmentioning

confidence: 99%

Features of the Formation of a Reinforcing Coating on Hydrogel Membranes Based on Polyvinylpyrrolidone Copolymers

Baran,

Grytsenko,

Dulebova

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

This paper presents the study results of formation features of composite hydrogel/polyamide membranes obtained by modification of hydrogel films based on 2-hydroxyethylmethacrylate (HEMA) and polyvinylpyrrolidone (PVP) copolymers. The formation process of composite two-layer membranes was carried out in two stages: obtaining hydrogel membrane substrates followed by their modification with an ultra-thin layer based on a mixture of polyamide (PA) with PVP. The main task of the work was to investigate the possibility of forming a modifying PA/PVP coating on the surface of hydrogel films and to obtain composite hydrogel membranes with the required strength and osmotic permeability based on them. For the formation of composite two-layer membranes, PVP with MM = 12 × 103 g/mol and MM = 360 × 103 g/mol were used. Additional use of PVP in the modifying solution contributes to the process of its penetration into the hydrogel substrate. Together with the formation of a reinforcing layer, this ensures the obtainment of hydrogel films of increased strength, with the possibility of directional regulation of their diffusion permeability. It was found that the main factors affecting the nature of the interaction between the layers of the obtained composite films, as well as their physico-mechanical and sorption–diffusion properties, are the HEMA:PVP ratio in the original polymer–monomer composition (PMC), the formulation of the reinforcing layer, the duration of the modification process and the molecular weight of PVP in PMC and in the modifying solution. The strength and water content of two-layer composite hydrogel/polyamide membranes, as well as their salt and water permeability coefficients, are the highest in the case of using high-molecular weight PVP (MMPVP = 360 × 103 g/mol) and low-molecular weight (MMPVP = 12 × 103 g/mol) during the synthesis of the hydrogel substrate to obtain a PA-6/PVP solution for forming a reinforcing layer.

show abstract

Impact of Hydrophilic Modification of Synthetic Dialysis Membranes on Hemocompatibility and Performance

Cited by 15 publications

References 102 publications

On the total albumin losses during haemocatharsis

On the total albumin losses during haemocatharsis

Strategies to Mitigate Biofouling of Nanocomposite Polymer-Based Membranes in Contact with Blood

Features of the Formation of a Reinforcing Coating on Hydrogel Membranes Based on Polyvinylpyrrolidone Copolymers

Contact Info

Product

Resources

About