Impact of human aging and modern lifestyle on gut microbiota

Gottlieb, Maria Gabriela Valle; Closs, Vera Elizabeth; Junges, Vilma Maria; Schwanke, Carla Helena Augustin

doi:10.1080/10408398.2016.1269054

Cited by 37 publications

(23 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our results are consistent with previous findings of different IM surveys in elderly individuals that outlined a drastic change in their IM as a consequence of the intestinal physiology deterioration, poor diet, and permanent medication. 19,20 Therefore, a loss of microbial diversity and change in the microbiome functionality is frequently associated with age, 21,22 making this population more disease prone. However, a disparate IM between men and women has been previously reported, as well as its covariation with BMI.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis

et al. 2020

View full text Add to dashboard Cite

Critically ill patients are physiologically unstable and recent studies indicate that the intestinal microbiota could be involved in the health decline of such patients during ICU stays. This study aims to assess the intestinal microbiota in critically ill patients with and without sepsis and to determine its impact on outcome variables, such as medical complications, ICU stay time, and mortality. A multi-center study was conducted with a total of 250 peri-rectal swabs obtained from 155 patients upon admission and during ICU stays. Intestinal microbiota was assessed by sequencing the V3-V4 hypervariable regions of the 16S rRNA gene. Linear mixed models were used to integrate microbiota data with more than 40 clinical and demographic variables to detect covariates and minimize the effect of confounding factors. We found that the microbiota of ICU patients with sepsis has an increased abundance of microbes tightly associated with inflammation, such as Parabacteroides, Fusobacterium and Bilophila species. Female sex and aging would represent an increased risk for sepsis possibly because of some of their microbiota features. We also evidenced a remarkable loss of microbial diversity, during the ICU stay. Concomitantly, we detected that the abundance of pathogenic species, such as Enterococcus spp., was differentially increased in sepsis patients who died, indicating these species as potential biomarkers for monitoring during ICU stay. We concluded that particular intestinal microbiota signatures could predict sepsis development in ICU patients. We propose potential biomarkers for evaluation in the clinical management of ICU patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Understanding how the gut microbiome responds to these factors is important because perturbations of gut microbial communities beyond their natural range may have serious impact on the host health (Cheng et al, 2015). Recent studies in human have noted that departing from ancestral lifestyle and adapting to urban life that involves modifications of lifestyle, diet, and living environment reduces the diversity and stability of gut microbiome (Schnorr et al, 2014;Conlon and Bird, 2015;Martínez et al, 2015;Obregon-Tito et al, 2015;Rampelli et al, 2015;Valle Gottlieb et al, 2017). As observed in the case of modern human, under captive conditions, most of the animal species including mammals, birds, and amphibians experience radical shifts in their diet and living environment, sharply reduced geographic range, controlled social interactions, and increased exposure to medical interventions that contrast from their way of living in the wild (Hird, 2017;McKenzie et al, 2017;Metcalf et al, 2017;Martínez-Mota et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Consequences of Domestication on Gut Microbiome: A Comparative Study Between Wild Gaur and Domestic Mithun

et al. 2020

View full text Add to dashboard Cite

Although the gut microbiome benefits the host in several ways, how anthropogenic forces impact the gut microbiome of mammals is not yet completely known. Recent studies have noted reduced gut microbiome diversity in captive mammals due to changes in diet and living environment. However, no studies have been carried out to understand how the gut microbiome of wild mammals responds to domestication. We analyzed the gut microbiome of wild and captive gaur and domestic mithun (domestic form of gaur) to understand whether the gut microbiome exhibits sequential changes from wild to captivity and after domestication. Both captive and domestic populations were characterized by reduced microbial diversity and abundance as compared to their wild counterparts. Notably, two beneficial bacterial families, Ruminococcaceae and Lachnospiraceae, which are known to play vital roles in herbivores' digestion, exhibited lower abundance in captive and domestic populations. Consequently, the predicted bacterial functional pathways especially related to metabolism and immune system showed lower abundance in captive and domestic populations compared to wild population. Therefore, we suggest that domestication can impact the gut microbiome more severely than captivity, which might lead to adverse effects on host health and fitness. However, further investigations are required across a wide range of domesticates in order to understand the general trend of microbiome shifts in domestic animals.

show abstract

“…According to some studies, the number and diversity of these increase with the age of the host. While other studies suggest the opposite, a reduction and loss of diversity of the microbiota over time, with deficient and dysbiotic functioning influenced by age, environmental factors and lifestyle (18).…”

Section: From the Intestinal Flora To The Microbiomementioning

confidence: 82%

From the intestinal flora to the microbiome

Domingo

Sánchez²

2017

Rev Esp Enferm Dig

View full text Add to dashboard Cite

In this article, the history of the microbiota is reviewed and the related concepts of the microbiota, microbiome, metagenome, pathobiont, dysbiosis, holobiont, phylotype and enterotype are defined. The most precise and current knowledge about the microbiota is presented and the metabolic, nutritional and immunomodulatory functions are reviewed. Some gastrointestinal diseases whose pathogenesis is associated with the intestinal microbiota, including inflammatory bowel disease, irritable bowel syndrome and celiac disease, among others, are briefly discussed. Finally, some prominent and promising data with regard to the fecal microbiota transplantation in certain digestive illness are discussed.

show abstract

Impact of human aging and modern lifestyle on gut microbiota

Cited by 37 publications

References 60 publications

Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis

Gut microbiota profiles in critically ill patients, potential biomarkers and risk variables for sepsis

Consequences of Domestication on Gut Microbiome: A Comparative Study Between Wild Gaur and Domestic Mithun

From the intestinal flora to the microbiome

Contact Info

Product

Resources

About