Impact of HSCT Conditioning and Glucocorticoid Dose on Exercise Adherence and Response

Wiskemann, Joachim; Herzog, Benedikt; Kuehl, Rea; Schmidt, Martina E.; Steindorf, Karen; Schwerdtfeger, Rainer; Dreger, Peter; Bohus, Martin

doi:10.1249/mss.0000000000001357

Cited by 6 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the health-related challenges that patients face after receiving allo-HSCT, they tend to have a relatively high adherence rate to physical exercise. One study showed that the adherence rate to a physical exercise plan of five sessions weekly during the inpatient period was 64% in myeloablative conditioning, 54% in reduced-intensity conditioning, and 63% in nonmyeloablative conditioning in 113 allo-HSCT patients 52 . Another study reported a 90% average adherence rate to a supervised multimodal exercise program performed five times per week for four to six weeks during the inpatient period after allo-HSCT in 42 allo-HSCT patients 44 ; similarly, 12 elderly allo-HSCT patients in a different study showed an 85% adherence rate 53 .…”

Section: Feasibility Of Physical Exercise For Allo-hsct Patientsmentioning

confidence: 99%

The Benefit of Exercise in Patients Who Undergo Allogeneic Hematopoietic Stem Cell Transplantation

Morishita

Tsubaki

Hotta

et al. 2019

The Journal of the International Society of Physical and Rehabilitation Medicine

View full text Add to dashboard Cite

Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) is increasingly used in the treatment of hematologic cancers such as leukemias, lymphomas, and myeloma, and for other hematologic disorders such as primary immunodeficiency, aplastic anemia, and myelodysplasia. Allo-HSCT entails a conditioning regimen of frequent high-dose chemotherapy in combination with total body irradiation, followed by infusion of donor-harvested bone marrow or peripheral blood stem cells. As an aggressive and demanding medical therapy that profoundly impacts patient quality of life (QOL), allo-HSCT is associated with numerous treatment-related physical, psychological, and psychosocial side effects. The procedure can result in decreased respiratory and balance function, skeletal muscle strength, and exercise capacity. Thus, as physical exercise has been shown to positively effect physical and psychosocial function and QOL in allo-HSCT patients, it is a recommended intervention for improving essential functions and offsetting lost exercise capacity after the procedure. Furthermore, recent evidence has shown that physical exercise can influence survival rate and mortality in allo-HSCT patients. This review provides an overview of the current research on the effectiveness of physical exercise for allo-HSCT patients.

show abstract

Section: Feasibility Of Physical Exercise For Allo-hsct Patientsmentioning

confidence: 99%

The Benefit of Exercise in Patients Who Undergo Allogeneic Hematopoietic Stem Cell Transplantation

Morishita

Tsubaki

Hotta

et al. 2019

The Journal of the International Society of Physical and Rehabilitation Medicine

View full text Add to dashboard Cite

show abstract

“…First, research has shown that allo-HSCT patients conditioned with elevated doses of chemotherapy and radiotherapy exercise for shorter periods of time when compared to patients receiving less aggressive protocols. 49 These patients also experience GVHD and toxicities with more severity and have increased length of cytopenia, 50,51 which translates into higher risk of infections and more isolation days. 52 Second, nearly 90% of the participants who developed GVHD during hospitalization participated in fewer classes.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a group‐based exercise and relaxation rehabilitation program during hospitalization for allogeneic hematopoietic stem cell transplant

Camacho

Mayo

Lipton

et al. 2022

PM&R

View full text Add to dashboard Cite

Background: Exercise and relaxation interventions have demonstrated benefits in allogeneic hematopoietic stem cell transplant (allo-HSCT) patients; however, little is known about the implementation enablers and barriers for inpatient rehabilitation or its impact on health outcomes. Objective: To conduct a program evaluation of group-based rehabilitation consisting of exercise and relaxation classes for allo-HSCT inpatients. Design: Prospective program evaluation using the RE-AIM (reach, effectiveness, adoption, implementation, and maintenance) framework. Setting: Inpatient hospital unit at a tertiary care center. Participants: Forty-five adult patients admitted for allo-HSCT. Interventions: Standard of care rehabilitation. Main Outcome Measures: Program attendance, safety, satisfaction, and fidelity were assessed. Exploratory effectiveness analyses were conducted via the measurement of physical, psychosocial, clinical, and health resource use outcomes at hospital admission and discharge. Results: Forty-seven of the 63 patients receiving allo-HSCT between November 2019 and March 2020 were consented. Data presented in this publication are from the 33 participants who completed study assessments (high attrition due to cancellation of research during the COVID-19 pandemic). Eighty-two percent of participants attended at least one class; however, 55% of the participants invited to the classes on a daily basis were not able to attend. Barriers to participation included transplant complications, isolation for infection prevention, and fatigue. There were no adverse events associated with the intervention and 82% of participants adhered to the prescribed activities. Participants reported satisfaction with the program and enjoyed the motivational support and social interaction. Between hospital admission and discharge, anxiety scores improved; however, fatigue, depression, grip strength, functional mobility, and quality of life scores declined. Physical activity volume and lower body strength were maintained. Conclusions: Group-based exercise and relaxation classes seem to be feasible and safe during hospitalization for allo-HSCT; however, there are pragmatic barriers to be considered for optimal program implementation. Further research examining program effectiveness and adoption is warranted.

show abstract

Impact of adherence in outcome of long‐term survivors

Eeltink¹,

Kisch²

2021

Blood and Marrow Transplantation Long Term Management

View full text Add to dashboard Cite

Impact of HSCT Conditioning and Glucocorticoid Dose on Exercise Adherence and Response

Cited by 6 publications

References 29 publications

The Benefit of Exercise in Patients Who Undergo Allogeneic Hematopoietic Stem Cell Transplantation

The Benefit of Exercise in Patients Who Undergo Allogeneic Hematopoietic Stem Cell Transplantation

Evaluation of a group‐based exercise and relaxation rehabilitation program during hospitalization for allogeneic hematopoietic stem cell transplant

Impact of adherence in outcome of long‐term survivors

Contact Info

Product

Resources

About