Impact of Housing Environment on the Immune System in Chickens: A Review

Hofmann, Tanja; Schmucker, Sonja; Bessei, W.; Grashorn, M. A.; Stefanski, Volker

doi:10.3390/ani10071138

Cited by 61 publications

(58 citation statements)

References 204 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In addition, cytokines are the predominant mediators of inflammation with an essential role in mediating the inflammatory response during heat stress in living organisms [ 38 ]. Several studies have confirmed the relationship between the inflammatory response of the immune organs and the expression of inflammatory cytokines [ 5 ]. The most effective role played by TNF-α, as the most important cytokine, is related to its potent cytoprotective and antioxidant activity in response to injuries [ 5 , 46 ], and activating lymphocytes and neutrophils to produce the other cytokines [ 47 ].…”

Section: Discussionmentioning

confidence: 97%

“…Several studies have confirmed the relationship between the inflammatory response of the immune organs and the expression of inflammatory cytokines [ 5 ]. The most effective role played by TNF-α, as the most important cytokine, is related to its potent cytoprotective and antioxidant activity in response to injuries [ 5 , 46 ], and activating lymphocytes and neutrophils to produce the other cytokines [ 47 ]. The TNF-α was down-regulated in the AST80 treatment but not in the AST40 or AST20 treatments.…”

Section: Discussionmentioning

confidence: 97%

“…The welfare and growth of animals are adversely under influence of heat stress, which causes economic losses by increasing mortality and reducing feed intake [ 3 , 10 ]. Corticosterone can be an indicator of chronic stress and will be increased during stress [ 5 ]. Previous reports confirmed that feather corticosterone of broiler chickens increases during long-term heat stress [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…The continuous selection of broiler chickens for fast growth has increased their vulnerability to heat stress than other farm animals. High ambient temperature in summer is thus a serious stressor for broiler chickens, resulting in poor health status, welfare, growth, and carcass quality [ 1 , 2 , 3 , 4 , 5 ]. In addition to decreased growth performance, exposure of broiler chicks to heat stress increases the oxidative reactions that compromise meat quality by affecting ultimate pH, water-holding capacity, meat color, and meat tenderness [ 4 , 6 ], resulting in lower marketability.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature

Hosseindoust

Oh²,

et al. 2020

Antioxidants

View full text Add to dashboard Cite

This study investigated the effect of dietary astaxanthin (AST) on the meat quality, antioxidant status, and immune response of chickens exposed to heat stress. Four hundred and eighty male broilers were assigned to four treatments including AST0, AST20, AST40, and AST80 with 0, 20, 40, and 80 ppm astaxanthin supplementation levels, respectively. There was a linear decrease of malondialdehyde (MDA) in leg muscle. Catalase and superoxide dismutase levels in the plasma were linearly increased. There was a linear increase in the level of total antioxidant capacity in the leg muscle. The 3-ethylbenzothiazoline-6-sulfonate reducing activity of leg muscle was significantly increased in the AST80 treatment. The AST40 treatment showed an increase in 2,2-diphenyl-1-picrylhydrazyl radical scavenging capacity of leg muscles. Breast meat redness and yellowness were linearly increased. The astaxanthin-supplemented treatments exhibited lower drip loss and MDA concentration of leg muscle compared with the AST0 treatment at days 3 and 9 of storage. Supplementation of 40 or 80 mg/kg astaxanthin significantly decreased heat shock protein (HSP)27, HSP70, tumor necrosis factor alpha, and interleukin-6 expression in the livers. The feather corticosterone was significantly lower in the astaxanthin-supplemented treatments than in the AST0 treatment. In conclusion, astaxanthin decreased the hyperthermic stress level and improved meat quality, and antioxidant status of chickens exposed to heat stress.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Muscle Antioxidant Activity and Meat Quality Are Altered by Supplementation of Astaxanthin in Broilers Exposed to High Temperature

Hosseindoust

Oh²,

et al. 2020

Antioxidants

View full text Add to dashboard Cite

show abstract

“…Air quality, especially increased ammonia (NH 3 ) and hydrogen sulfide (H 2 S) concentrations, is an important factor influencing poultry health and bird performance, including feed efficiency, growth rate, carcass quality, and susceptibility to diseases. Indeed, harmful concentrations of NH 3 and H 2 S can suppress/dampen adaptive immune responses [ 239 ].…”

Section: Effect Of Various Stress Factors On Nf-κb Expression and mentioning

confidence: 99%

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

2021

View full text Add to dashboard Cite

Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general, all redox elements are interconnected and regulated by various means, including antioxidant and vitagene networks. The redox status is responsible for maintenance of cell signaling and cell stress adaptation. Physiological roles of redox homeostasis maintenance in avian species, including poultry, have received limited attention and are poorly characterized. However, for the last 5 years, this topic attracted much attention, and a range of publications covered some related aspects. In fact, transcription factor Nrf2 was shown to be a master regulator of antioxidant defenses via activation of various vitagenes and other protective molecules to maintain redox homeostasis in cells/tissues. It was shown that Nrf2 is closely related to another transcription factor, namely, NF-κB, responsible for control of inflammation; however, its roles in poultry have not yet been characterized. Therefore, the aim of this review is to describe a current view on NF-κB functioning in poultry with a specific emphasis to its nutritional modulation under various stress conditions. In particular, on the one hand, it has been shown that, in many stress conditions in poultry, NF-κB activation can lead to increased synthesis of proinflammatory cytokines leading to systemic inflammation. On the other hand, there are a range of nutrients/supplements that can downregulate NF-κB and decrease the negative consequences of stress-related disturbances in redox homeostasis. In general, vitagene–NF-κB interactions in relation to redox balance homeostasis, immunity, and gut health in poultry production await further research.

show abstract