Impact of HIV risk factors on survival in Iranian HIV-infected patients: A Bayesian approach to retrospective cohort

Maracy, Mohammad Reza; Mostafaei, Shayan; Moghoofei, Mohsen; Mansourian, Marjan

doi:10.5114/hivar.2017.68117

Cited by 20 publications

(12 citation statements)

References 29 publications

(31 reference statements)

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“…The results also showed that sexual transmission of HIV is signi cantly associated with the survival of HIV infected patients. This nding is consistent with other studies that conducted by Maracy et al in Iran [27].…”

Section: Resultssupporting

confidence: 93%

The Survival Rate and Its Predictors in HIV-Infected Patients of Kurdistan Province, Iran: A Retrospective Cohort Study

Darvishi

Rahmani

Seyfi

et al. 2020

Preprint

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Abstract Objective: This study aimed to understand the prognostic factors that influence the progress and death in human immunodeficiency virus (HIV) / acquired immunodeficiency syndrome (AIDS) patients in developing countries. This study conducted in the Kurdistan Province, Iran from September 1988 to April 2020. Interest outcomes were time-estimated: (1) from HIV to AIDS and (2) from AIDS to death. The Cox proportional-hazard model also was used in order to consider the effects of different factors on survival rate.Results: A total number of 591 HIV-infected patients were assessed and the results showed that 1-year, 5-year, and 10-year probability of disease progression from HIV diagnosis to AIDS was 96%, 92%, and 88%, and that of death was 69%, 47%, and 27%, respectively. Cox’s multivariate analysis result's showed the following factors were significantly related to AIDS progression: the first CD4 count under 500, using ART, and history of drug use with hazard ratio of 1.93, 4.53, and 0.76, respectively. The mortality was significantly associated with unemployment, using ART with HR of 3.4, and 0.07, respectively. Unemployed AIDS-patients are also more likely to die; this, which need more attention in Iran.

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Section: Resultssupporting

confidence: 93%

The Survival Rate and Its Predictors in HIV-Infected Patients of Kurdistan Province, Iran: A Retrospective Cohort Study

Darvishi

Rahmani

Seyfi

et al. 2020

Preprint

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“…Alternatively, viruses that contribute to a persistent infection, including HIV, HCV, and HBV, have developed multiple strategies to subvert or evade the immune responses. The mechanisms for this immune‐escape strategy have still to be fully understood . It has been shown that miR‐146a regulates the production of inflammatory cytokines by targeting IRAK1.…”

Section: Mir‐146a In Hbv/hcvmentioning

confidence: 99%

“…The mechanisms for this immune-escape strategy have still to be fully understood. [41][42][43][44] It has been shown that miR-146a regulates the production of inflammatory cytokines by targeting IRAK1. Forkhead-box transcription factors (FOXP3), which is known as specific Treg cells marker and controls the function and development of Treg cells.…”

Section: Mir-146amentioning

confidence: 99%

The role of miR‐146a in viral infection

et al. 2019

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Cellular microRNAs (miRNAs) were identified as a key player in the posttranscriptional regulation of cellular‐genes regulatory pathways. They also emerged as a significant regulator of the immune response. In particular, miR‐146a acts as an importance modulator of function and differentiation cells of the innate and adaptive immunity. It has been associated with disorder including cancer and viral infections. Given its significance in the regulation of key cellular processes, it is not surprising which virus infection have found ways to dysregulation of miRNAs. miR‐146a has been identified in exosomes (exosomal miR‐146a). After the exosomes release from donor cells, they are taken up by the recipient cell and probably the exosomal miR‐146a is able to modulate the antiviral response in the recipient cell and result in making them more susceptible to virus infection. In this review, we discuss recent reports regarding miR‐146a expression levels, target genes, function, and contributing role in the pathogenesis of the viral infection and provide a clue to develop the new therapeutic and preventive strategies for viral disease in the future.

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“…B19V infection and the consequent anemia are considered serious issues in HIV patients. A proportion of patients are cured by blood transfusions and high-dose intravenous immunoglobulin (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Association between Parvovirus B19 and anemia in HIV-infected patients

Nouri

Kamakifar

Khodabandehlou

et al. 2019

Med. J. Islam. Republ. Iran

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Parvovirus B19 infection is involved in several clinical manifestations such as erythema infectiosum, chronic arthritis, hydrops fetalis, and transient aplastic crisis in patients with sickle cell anemia and pure red cell aplasia in immunocompromised hosts. This virus can lead to self-limited anemia in healthy individuals; however, it can develop into chronic anemia in immunocompromised cases. →What this article adds: The present study evaluated the association between anemia and B19V in HIV patients. Also, the threat of B19V is limited in the HIV patients receiving ART, whereas persistent B19 viremia in the untreated patients may lead to anemia.

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Impact of HIV risk factors on survival in Iranian HIV-infected patients: A Bayesian approach to retrospective cohort

Cited by 20 publications

References 29 publications

The Survival Rate and Its Predictors in HIV-Infected Patients of Kurdistan Province, Iran: A Retrospective Cohort Study

The Survival Rate and Its Predictors in HIV-Infected Patients of Kurdistan Province, Iran: A Retrospective Cohort Study

The role of miR‐146a in viral infection

Association between Parvovirus B19 and anemia in HIV-infected patients

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