Impact of HIV Infection and HAART Therapy on CD4 T Helper Cell Subset Expression and Function

Guzzo, Christina; Mat, Nor Fazila Che; Zhang, Xiubo; Gee, Katrina

doi:10.5772/20914

Cited by 1 publication

(1 citation statement)

References 125 publications

(119 reference statements)

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“…The serum concentrations of circulating IL-12p70 were negatively associated with the numbers of CD4 T-cells, CD19+ B-cells, and FoxP3 expression (Table 1while they were positively associated with the numbers of CD8 T-cells, NK-cells, and CD8+CD38 expression (Table 1) in the current study. IL-12p70 is known to play a critical role in the generation of cell mediated immune responses to infectious agents including HIV-1 [60], thus the association of IL-12p70 with the numbers of CD8 T-cells and NK-cells observed in the current study confirm this role. IL-12p70 may stimulate the activities of CD8 and NK-cells as confirmed by positive correlation of IL-12p70 with increased CD8+CD38 expression.…”

Section: Interleukin-12p70 (Il-12p70)supporting

confidence: 80%

Inflammation in HIV Positive Non Hodgkin Lymphoma Patients

Flepisi¹

2017

JOJIV

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Background: HIV-1 infection is associated with dysregulation of cytokine production and this is thought to contribute to HIV associated immune deficiency. The dysregulation of cytokine production may be playing a role in the pathogenesis of HIV+ NHL, as evidenced by increased prevalence of NHL in HIV-1 infection. This study aimed to determine the serum concentrations of circulating inflammatory cytokines and the effect of cART in HIV positive NHL patients.Methods: The serum concentrations of IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, and TNF-α were determined by mesoscale discovery (MSD) assay in 141 subjects that were divided into 5 groups: naive HIV+ ; cART treated HIV+ ; HIV negative NHL; HIV+ NHL and healthy controls.Results: HIV+ NHL patients had higher serum concentrations of IL-4 as compared to NHL and HIV+ cART patients. As compared to NHL patients, the serum concentrations of IL-2, and TNF-α were significantly higher in HIV+ NHL patients, while those of IL-1β were significantly lower. HIV+ NHL patients had higher serum concentrations of IFN-γ, and IL-6; and lower serum concentrations of IL-12p70 than HIV+ cART patients. All the inflammatory cytokines were significantly increased in NHL as compared to the controls, as well as in cART-naïve HIV+ patients as compared to HIV+ cART and controls. Conclusion:The serum concentrations of inflammatory cytokines are increased in HIV positive NHL patients. This suggests that chronic inflammation may play a role in the pathogenesis of lymphoma.

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Section: Interleukin-12p70 (Il-12p70)supporting

confidence: 80%

Inflammation in HIV Positive Non Hodgkin Lymphoma Patients

Flepisi¹

2017

JOJIV

View full text Add to dashboard Cite

show abstract

Impact of HIV Infection and HAART Therapy on CD4 T Helper Cell Subset Expression and Function

Cited by 1 publication

References 125 publications

Inflammation in HIV Positive Non Hodgkin Lymphoma Patients

Inflammation in HIV Positive Non Hodgkin Lymphoma Patients

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