Impact of histopathology of non-neoplastic thyroid tissue on ablation outcome in patients with papillary thyroid cancer

Abstract

Histopathology of non-neoplastic thyroid tissue has a significant impact on ablation outcome in patients with PTC. Patients with a histopathology of non-neoplastic thyroid tissue of autoimmune origin have a significantly lower incidence of successful complete ablation after a single I-131 ablative dose (100 mCi) compared with those with nonautoimmune histopathology or with normal thyroid tissue.

Effect of Hashimoto thyroiditis on low‐dose radioactive‐iodine remnant ablation

“…Inflammatory changes of thyroid tissue may also play a role. In a recent clinical study, high dose (3700 MBq) radioactive‐iodine remnant ablation demonstrated a lower success rate of 33.4% in patients with thyroiditis, whereas patients without thyroiditis had a success rate of 80% …”

Comparison between low and high radioactive iodine (131I) reablation dose in patients with papillary thyroid cancer

“…The latter authors [17] reported an ablation outcome of 89.7% for 100 mCi (3700 MBq). These include remnant size, the given 131 I dose, stunning effect [19,20], 131 I uptake, tumor stage, and the histopathology of non-neoplastic thyroid tissue [14]. The difference in ablation outcomes reported by different authors is actually related to multiple factors that affect the ablation outcome and are interlinked with each other.…”

Successful Complete Ablation Rate Post a Second Ablation Dose of 30 mCi Radioactive Iodine (I131) in Patients with Papillary Thyroid Cancer

“…[10] . Maxon et al, 1992 [11] reported complete ablation in 86% of patients using initial dose of 100 mCi, Where (2006) Zaman et al reported an ablation rate of 54% was achieving the same dose [9] .…”

“…Multiple studies have established the adequacy of low dose I131 in successfully ablating remnant thyroid in selected patients with a first ablation dose as low as 30-50 mCi [10] . To our knowledge no single study assessed the successful complete ablation rate post a second low ablation dose in patients who failed to achieve complete ablation after the first ablation dose.…”