Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

Xylinas, Évanguelos; Rink, Michael; Robinson, Brian D.; Lotan, Yair; Babjuk, Marek; Brisuda, A.; Green, David A.; Kluth, Luis A.; Pycha, Armin; Fradet, Yves; Faison, Talia; Lee, Richard K.; Karakiewicz, Pierre I.; Zerbib, Marc; Scherr, Douglas S.; Shariat, Shahrokh F.

doi:10.1016/j.ejca.2013.02.001

Cited by 156 publications

(113 citation statements)

References 18 publications

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“…Furthermore, on Cox proportional hazards regression, only pathologic staging and LN status were associated with increased risk of disease specific and all-cause mortality. Our findings are consistent with previously reported studies that have shown that SQD does not portend worse survival on multivariate analysis 6,7,11,23 .…”

Section: Discussionsupporting

confidence: 83%

“…Kim et al found that variant tumors had almost double the incidence of non-organ confined disease as well as increased LN involvement 7 . These findings were corroborated by Xylinas et al that also demonstrated more advanced pathologic staging and LN involvement in SQD patients 23 . We too demonstrate more advanced pathologic staging in our SQD patients, but we found no significant difference in LN status at the time of radical cystectomy.…”

Section: Discussionsupporting

confidence: 78%

“…Consistent with the TURBT findings, SQD have historically been known to have more advanced pathologic disease 7,8,23 . Kim et al found that variant tumors had almost double the incidence of non-organ confined disease as well as increased LN involvement 7 .…”

Section: Discussionsupporting

confidence: 69%

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Does Squamous Differentiation Portend Worse Outcomes in Urothelial Bladder Cancer?

et al. 2015

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 78%

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Does Squamous Differentiation Portend Worse Outcomes in Urothelial Bladder Cancer?

et al. 2015

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“…5a, Table 2). Urothelial carcinoma has long been known to have a remarkable propensity for divergent differentiation, which is seen most commonly in association with high-grade and locally advanced disease [59][60][61][62]. The incidence of divergent differentiation in cystectomy specimens is as high as 33%.…”

Section: Invasive Urothelial Carcinoma With Divergent Differentiationmentioning

confidence: 99%

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

et al. 2016

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It has been 12 yr since the publication of the last World Health Organization (WHO) classification of tumours of the prostate and bladder. During this time, significant new knowledge has been generated about the pathology and genetics of these tumours. Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 WHO classification. In most cases, it represents intraductal spread of aggressive prostatic carcinoma and should be separated from high-grade prostatic intraepithelial neoplasia. New acinar adenocarcinoma variants are microcystic adenocarcinoma and pleomorphic giant cell adenocarcinoma. Modifications to the Gleason grading system are incorporated into the 2016 WHO section on grading of prostate cancer, and it is recommended that the percentage of pattern 4 should be reported for Gleason score 7. The new WHO classification further recommends the recently developed prostate cancer grade grouping with five grade groups. For bladder cancer, the 2016 WHO classification continues to recommend the 1997 International Society of Urological Pathology grading classification. Newly described or better defined noninvasive urothelial lesions include urothelial dysplasia and urothelial proliferation of uncertain malignant potential, which is frequently identified in patients with a prior history of urothelial carcinoma. Invasive urothelial carcinoma with divergent differentiation refers to tumours with some percentage of "usual type" urothelial carcinoma combined with other morphologies. Pathologists should mention the percentage of divergent histologies in the pathology report. PATIENT SUMMARY Intraductal carcinoma of the prostate is a newly recognized entity in the 2016 World Health Organization classification. Better defined noninvasive urothelial lesions include urothelial dysplasia and urothelial proliferation of uncertain malignant potential. v a i l a b l e a t w w w . s c i e n c e d i r e c t . c o m j AbstractIt has been 12 yr since the publication of the last World Health Organization (WHO) classification of tumours of the prostate and bladder. During this time, significant new knowledge has been generated about the pathology and genetics of these tumours.

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“…Xylinas et al analyzed differences between pure urothelial BC and that with variant histology in 1,984 patients treated with RC. The authors reported worse outcomes with variant groups in univariate analyses, which was not the case in multivariable analyses as T category was the strongest factor for outcome and not the histologic variant of tumor (94).…”

Section: Prognosis In Bladder Cancer After Cystectomy Clinical and Pamentioning

confidence: 97%

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

Aljabery¹

2017

Linköping University Medical Dissertations

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Aim: To study the possibility of detecting lymph node metastasis in locally advanced urinary bladder cancer (UBC) treated with radical cystectomy (RC) by using preoperative positron emission tomography/computed tomography (PET/CT) and peroperative sentinel node biopsy (SNB) technique. We also investigate the clinical significance of macrophage traits expression by cancer cells, M2-macrophage infiltration (MI) in tumor stroma and the immunohistochemical expression of biomarkers in cancer cells in relation to clinico-pathologic data. Patients and Methods:We studied prospectively 122 patients with UBC, pathological stage pT1-pT4 treated with RC and pelvic lymph node dissection (PLND) during [2005][2006][2007][2008][2009][2010][2011] at the Department of Urology, Linköping University Hospital. In the first study, we compared the results of preoperative PET/CT and conventional CT with the findings of postoperative histopathological evaluation of lymph nodes (LNs). In the second study we investigated the value of SNB technique for detecting pathological LNs during RC in patients with UBC. We also examined the significance of the primary tumor location in the bladder in predicting the site of LN metastases, and the prognostic significance of lympho-vascular invasion (LVI) and lymph node metastasis density (LNMD) on survival. In the third study, we investigate the clinical significance of macrophage infiltration (MI) in tumor stroma and macrophage-traits expression by tumor cells. In the fourth study, we investigate the cell cycle suppression pro-

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Impact of histological variants on oncological outcomes of patients with urothelial carcinoma of the bladder treated with radical cystectomy

Cited by 156 publications

References 18 publications

Does Squamous Differentiation Portend Worse Outcomes in Urothelial Bladder Cancer?

Does Squamous Differentiation Portend Worse Outcomes in Urothelial Bladder Cancer?

The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs—Part B: Prostate and Bladder Tumours

Staging and tumor biological mechanisms of lymph node metastasis in invasive urinary bladder cancer

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