Impact of highly active antiretroviral therapy on nutritional and immunologic status in HIV-infected children in the low-income country of Ethiopia

Ebissa, Getachew; Deyessa, Negusse; Biadgilign, Sibhatu

doi:10.1016/j.nut.2015.12.035

Cited by 13 publications

(19 citation statements)

References 20 publications

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“…In our study, though severe malnutrition was not an independent predictor of mortality in the multivariate Cox regression modeling; it was associated with mortality in the bivariate modeling. This finding contrasts the finding of study in Kenya [6,12,26].…”

Section: Discussioncontrasting

confidence: 99%

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Incidence and Predictors of Mortality among Children on Anti-Retroviral Therapy in Public Health Facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective Cohort Study

Boti¹,

Debere²,

Enderis³

et al. 2017

Clinics Mother Child Health

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Section: Discussioncontrasting

confidence: 99%

“…Evidence show that earlier access to ART shows that it help to increase survival of children by delaying the progression to AIDS [6,7]. It was estimated that earlier access to ART could have prevented 25% of HIV related death [8,9].…”

Section: Introductionmentioning

confidence: 99%

Incidence and Predictors of Mortality among Children on Anti-Retroviral Therapy in Public Health Facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective Cohort Study

Boti¹,

Debere²,

Enderis³

et al. 2017

Clinics Mother Child Health

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“…Studies have shown that HIV-positive children who present with a low weight-for-height Z score (i.e. wasted) have less immunologic recovery at the different follow-up visits, suggesting that these children should receive nutritional supplementation, especially during the early months following ART initiation (Ebissa, Deyessa, & Biadgilign, 2016). Improvements in anthropometry have been demonstrated in undernourished HIV-infected children following the initiation of ART, irrespective of baseline nutritional status or the provision of nutritional supplements (Davies et al, 2009;Sutcliffe et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Dietary intake among paediatric HIV-positive patients initiating antiretroviral therapy in Johannesburg, South Africa

Musakwa

Feeley²,

Magwete

et al. 2019

Vulnerable Children and Youth Studies

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“…Although ART is effective in improving the nutritional status, a significant percentage of patients continue to be nutritionally deficient , so it seems appropriate to support the initiation of ART with a nutritional intervention. Malnourished patients show worse immune reconstitution after the initiation of ART than patients with a normal nutritional level .…”

Section: Discussionmentioning

confidence: 99%

Nutritional, clinical and immunological status of children at HIV diagnosis in the continental region of Equatorial Guinea

Aguilera‐Alonso¹,

Grasa

Hernández

et al. 2019

Tropical Med Int Health

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objective To evaluate the nutritional, clinical and immunological status of children at HIV diagnosis in the continental region of Equatorial Guinea.methods Children <18 years diagnosed with HIV between 2009 and 2017 were included. Clinical, immunological and nutritional data were collected. Weight-for-height, weight-for-age and height-forage Z-scores were calculated using WHO Child Growth Standards. The population was assessed in two equal periods (2009-2013 and 2014-2017) from the time of diagnosis.results A total of 213 children were diagnosed with HIV (49.3% males), median age 3.8 years (IQR: 1.5-8.2). A total of 121 cases (56.8%) were at WHO clinical stage III, and 53 (24.9%) were at WHO clinical stage IV. CDC immunological stage II was diagnosed in 51/130 (39.2%) and CDC stage III in 44/130 (33.8%). About 56.2% of children were underweight (weight-for-age <À2 SD); 20.1% moderately and 36.1% severely so. About 27.6% of children were wasted (weight-for-height <À2 SD); 11.9% moderately and 15.7% severely so. About 56.3% of children were stunted (heightfor-age <À2 SD); 20.7% moderately and 35.6% severely so. The prevalence of wasting was higher in children ≤5 years than in children >5 years (36.4% vs. 19.1%, P = 0.026). In the second period, the prevalence of moderate-severe immunodeficiency decreased (87.2% to 67.0%, P = 0.018), without significant differences in the other nutritional or clinical data. Severe underweight was a risk factor for moderate-severe immunodeficiency (aOR: 4 [95% CI: 1.4-11.4], P = 0.010).conclusions We highlight a high proportion of malnutrition at the time of HIV diagnosis in Guinea´s paediatric population. Early diagnosis of HIV infection is a priority, achievable by training Guinea´s physicians to suspect HIV early, introducing HIV molecular diagnostic techniques and ensuring intensive nutritional treatment.Sustainable Development Goals (SDGs): SDG 2 (zero hunger), SDG 3 (good health and well-being), SDG 10 (reduced inequalities), SDG 17 (partnerships for the goals)

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Impact of highly active antiretroviral therapy on nutritional and immunologic status in HIV-infected children in the low-income country of Ethiopia

Cited by 13 publications

References 20 publications

Incidence and Predictors of Mortality among Children on Anti-Retroviral Therapy in Public Health Facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective Cohort Study

Incidence and Predictors of Mortality among Children on Anti-Retroviral Therapy in Public Health Facilities of Arba Minch Town, Gamo Gofa Zone, Southern Ethiopia; Retrospective Cohort Study

Dietary intake among paediatric HIV-positive patients initiating antiretroviral therapy in Johannesburg, South Africa

Nutritional, clinical and immunological status of children at HIV diagnosis in the continental region of Equatorial Guinea

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