Impact of Highly Active Antiretroviral Therapy on Individual AIDS-Defining Illness Incidence and Survival in Australia

Dore, Gregory J.; Li, Yueming; McDonald, Ann; Rée, Hugo; Kaldo, John M.

doi:10.1097/00126334-200204010-00010

Cited by 103 publications

(30 citation statements)

References 29 publications

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“…[8] Similar findings have also been reported from the United States and Europe. [9][10] HIV prevalence in India is approximately 0.36% in the age group of 15-49 years, accounting for 2-3.1 million people.…”

Section: Introductionsupporting

confidence: 80%

HIV-associated non-Hodgkin′s lymphoma: Experience from a regional cancer center

et al. 2010

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Section: Introductionsupporting

confidence: 80%

HIV-associated non-Hodgkin′s lymphoma: Experience from a regional cancer center

et al. 2010

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“…Among international studies, the greatest survival encountered in recent years comes from the study by Dore et al [11], in Australia, with cases defined between 1993 and 2000, using the CDC case definition. Among international studies, the greatest survival encountered in recent years comes from the study by Dore et al [11], in Australia, with cases defined between 1993 and 2000, using the CDC case definition.…”

Section: Discussionmentioning

confidence: 99%

Survival of AIDS patients using two case definitions, Rio de Janeiro, Brazil, 1986–2003

Campos

Ribeiro

Grinsztejn

et al. 2005

Aids

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“…A significant improvement in the prognosis of the HIV/AIDS population was observed after the introduction and widespread use of highly active antiretroviral therapy (HAART) [1]. During HAART era, the causes of hospitalization and death among HIV/AIDS patients have changed, with a relative increase on noninfectious conditions and non–AIDS-defining infections [2-5].…”

Section: Introductionmentioning

confidence: 99%

The Innate Immune Response in HIV/AIDS Septic Shock Patients: A Comparative Study

et al. 2013

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IntroductionIn recent years, the incidence of sepsis has increased in critically ill HIV/AIDS patients, and the presence of severe sepsis emerged as a major determinant of outcomes in this population. The inflammatory response and deregulated cytokine production play key roles in the pathophysiology of sepsis; however, these mechanisms have not been fully characterized in HIV/AIDS septic patients.MethodsWe conducted a prospective cohort study that included HIV/AIDS and non-HIV patients with septic shock. We measured clinical parameters and biomarkers (C-reactive protein and cytokine levels) on the first day of septic shock and compared these parameters between HIV/AIDS and non-HIV patients.ResultsWe included 30 HIV/AIDS septic shock patients and 30 non-HIV septic shock patients. The HIV/AIDS patients presented low CD4 cell counts (72 [7-268] cells/mm3), and 17 (57%) patients were on HAART before hospital admission. Both groups were similar according to the acute severity scores and hospital mortality. The IL-6, IL-10 and G-CSF levels were associated with hospital mortality in the HIV/AIDS septic group; however, the CRP levels and the surrogates of innate immune activation (cytokines) were similar among HIV/AIDS and non-HIV septic patients. Age (odds ratio 1.05, CI 95% 1.02-1.09, p=0.002) and the IL-6 levels (odds ratio 1.00, CI 95% 1.00-1.01, p=0.05) were independent risk factors for hospital mortality.ConclusionsIL-6, IL-10 and G-CSF are biomarkers that can be used to predict prognosis and outcomes in HIV/AIDS septic patients. Although HIV/AIDS patients are immunocompromised, an innate immune response can be activated in these patients, which is similar to that in the non-HIV septic population. In addition, age and the IL-6 levels are independent risk factors for hospital mortality irrespective of HIV/AIDS disease.

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Impact of Highly Active Antiretroviral Therapy on Individual AIDS-Defining Illness Incidence and Survival in Australia

Cited by 103 publications

References 29 publications

HIV-associated non-Hodgkin′s lymphoma: Experience from a regional cancer center

HIV-associated non-Hodgkin′s lymphoma: Experience from a regional cancer center

Survival of AIDS patients using two case definitions, Rio de Janeiro, Brazil, 1986–2003

The Innate Immune Response in HIV/AIDS Septic Shock Patients: A Comparative Study

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