Impact of High-Sucrose Diet on the mRNA Levels for Elongases and Desaturases and Estimated Protein Activity in Rat Adipose Tissue

Drąg, Jagoda; Knapik-Czajka, Małgorzata; Gawędzka, Anna; Gdula‐Argasińska, Joanna; Jaśkiewicz, Jerzy

doi:10.1134/s0006297921050011

Cited by 1 publication

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“…The relation between fatty acid metabolism and dietary carbohydrates has been examined over the years, providing consistent evidence of increased FADS2 expression in response to high carbohydrate diets in male rats ( 102 ) and in mice ( 103 ). The quantity of carbohydrates matter, for example, provision of sucrose, 30%, lead to reduced delta 5 desaturase activity ( 104 , 105 ) with no changes in delta 6 enzyme activity ( 105 ).…”

Section: Potential Covariates and Confounders Of Zn And Fads1/fads2 I...mentioning

confidence: 99%

Existing knowledge on Zn status biomarkers (1963–2021) with a particular focus on FADS1 and FADS2 diagnostic performance and recommendations for further research

Knez

Boy

2023

Front. Nutr.

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The role of Zn in human health was discovered 60 years ago, and despite remarkable research efforts, a sufficiently sensitive and specific biomarker of Zn status is still lacking. Plasma/serum Zn, currently the best available and most accepted population Zn status indicator, responds well to severe Zn deficiency, yet, mild to moderate Zn deficiency states usually remain unrecognized. Identifying early-stage Zn deficiency requires additional robust markers of Zn status. This paper discusses the sensitivity, specificity, and responsiveness of plasma Zn concentrations to Zn interventions. It describes the biochemical and dietary basis for the causal association between Zn and fatty acid desaturases activity, FADS1 and FADS2, based on data collected through studies performed in animals and/or humans. The influence of potential confounders and covariates on the observed relationships is considered. Additional potential Zn biomarkers are discussed and suggestions for further research in this area are provided.

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Section: Potential Covariates and Confounders Of Zn And Fads1/fads2 I...mentioning

confidence: 99%

Existing knowledge on Zn status biomarkers (1963–2021) with a particular focus on FADS1 and FADS2 diagnostic performance and recommendations for further research

Knez

Boy

2023

Front. Nutr.

View full text Add to dashboard Cite

show abstract

Impact of High-Sucrose Diet on the mRNA Levels for Elongases and Desaturases and Estimated Protein Activity in Rat Adipose Tissue

Cited by 1 publication

References 44 publications

Existing knowledge on Zn status biomarkers (1963–2021) with a particular focus on FADS1 and FADS2 diagnostic performance and recommendations for further research

Existing knowledge on Zn status biomarkers (1963–2021) with a particular focus on FADS1 and FADS2 diagnostic performance and recommendations for further research

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