Impact of high-intensity concurrent training on cardiovascular risk factors in persons with multiple sclerosis – pilot study

Abstract

Under the conditions of this pilot study, 12 weeks of concurrent high-intense interval and strength training improved resting heart rate, 2-h glucose and insulin sensitivity in multiple sclerosis but did not affect blood C-reactive protein levels, blood pressure, body composition and blood lipid profiles. Further, larger and controlled research investigating the effects of high-intense concurrent training on cardiovascular risk factors in multiple sclerosis is warranted. Implications for rehabilitation High-intensity concurrent training improves cardiovascular fitness. This pilot study explores the impact of this training on cardiovascular risk factors in multiple sclerosis. Despite the lack of a control group, high-intense concurrent training does not seem to improve cardiovascular risk factors in multiple sclerosis.

High intensity interval training for people with multiple sclerosis: A systematic review

“…Three of the studies, reported by seven articles, provided a power calculation and had a sample size large enough to be powered (Collett et al, 2011;Farup et al, 2016;Feltham et al, 2013;Wens et al, 2015;Wens et al, 2017;Zimmer et al, 2017). The other four studies did not report on power (Bansi et al, 2017;Collett et al, 2017;Keytsman et al, 2017;Skjerbaek et al, 2014;Zaenker et al, 2016). Only one study had a follow up period, which was 12 weeks after completion of the intervention (Collett et al, 2011) (Table 3).…”

“…Sample sizes ranged from 11 (Skjerbaek et al, 2014) to 61 (Collett et al, 2011) with a total number of 249 participants. Five studies included participants that were predominantly mildly disabled (EDSS < 4.0) (Collett et al, 2011;Collett et al, 2017;Farup et al, 2016;Feltham et al, 2013;Keytsman et al, 2017;Wens et al, 2015;Wens et al, 2017;Zaenker et al, 2016) one study recruited a predominantly moderately disabled group (EDSS 4.0-6.0) (Bansi et al, 2017;Zimmer et al, 2017) and one study recruited participants who were more severely disabled (EDSS 6.0-8.0) (Skjerbaek et al, 2014) (Table 3). Five studies included participants with both relapsing remitting MS and progressive MS (Bansi et al, 2017;Collett et al, 2011;Collett et al, 2017;Farup et al, 2016;Feltham et al, 2013;Wens et al, 2015;Wens et al, 2017;Zimmer et al, 2017), one study only included participants with progressive MS (Skjerbaek et al, 2014), and one study did not report on MS type (Keytsman et al, 2017).…”

“…All studies conducted HIIT, in a supervised setting, on a cycle ergometer apart from Skjerbaek et al 2014who used upper limb ergometry. Four studies (eight articles) compared HIIT to a form of continuous training (Bansi et al, 2017;Collett et al, 2011;Collett et al, 2017;Farup et al, 2016;Feltham et al, 2013;Wens et al, 2015;Wens et al, 2017;Zimmer et al, 2017), one study compared HIIT and in-patient rehabilitation to just in-patient rehabilitation (Skjerbaek et al, 2014), and two studies did not have a comparator group (Keytsman et al, 2017;Zaenker et al, 2016) (Table 3). Inclusion and exclusion criteria of all studies were standard compared to other exercise interventions in…”

“…Four studies (eight articles) combined HIIT with another form of exercise training; two with resistance training (Farup et al, 2016;Keytsman et al, 2017;Wens et al, 2015;Wens et al, 2017), one with continuous moderate intensity training (Collett et al, 2011;Feltham et al, 2013), and one with both resistance training and continuous moderate intensity training (Zaenker et al, 2016) (Table 3).…”

Weight control and physical exercise in people with multiple sclerosis: Current knowledge and future perspectives

“…Moreover, there was a significant intervention effect on whole-body bone mineral content and bone mineral density using unadjusted criteria values ( Table 2). Further studies (21) reported that 12 weeks of high-intensity concurrent training (i.e., interval and strength training) did not change total, fat and lean body mass, however, there were improvements in resting heart rate and insulin resistance.…”