Impact of high fat diet and exercise on bone and bile acid metabolism in rats
Nerea Alonso,
Gunter Almer,
Maria Donatella Semeraro
et al.
Abstract:Background: Bile acids help facilitate the intestinal lipids absorption, and have endocrine activity in glucose, lipid and bone metabolism. Obesity and exercise influence bile acid metabolism and have opposite effects in bone. This given study investigates if regular exercise helps mitigate the adverse effects of obesity on bone, potentially by reversing alterations in bile acid metabolism. Methods: Four-month-old female Sprague Dawley rats either received high fat diet (HFD) or chow-based standard diet (lean … Show more
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