Impact of Heptavalent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of Penicillin-Resistant Streptococcus pneumoniae Among Day-Care Center Attendees in Central Greece

Grivea, Ioanna N.; Panagiotou, Maria; Tsantouli, Alexandra G.; Syrogiannopoulos, George A.

doi:10.1097/inf.0b013e318168d28a

Cited by 42 publications

(39 citation statements)

References 31 publications

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“…Infant immunization coverage is high, but lower rates have been noted in older children and adolescents. 7,8 Sampling Of 6878 births in 2004, 3581 (52.1%) were reported in public and private maternity wards of Heraklion, the major city in the island. A representative sample was formed of 1049 (29% of the annual births) mothereinfant pairs, as described elsewhere.…”

Section: Methodsmentioning

confidence: 99%

Predisposing factors for acute otitis media in infancy

Ladomenou

Kafatos

Tselentis

et al. 2010

Journal of Infection

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Section: Methodsmentioning

confidence: 99%

Predisposing factors for acute otitis media in infancy

Ladomenou

Kafatos

Tselentis

et al. 2010

Journal of Infection

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“…We have been conducting cross-sectional surveillances of pneumococcal carriage among young children in various areas of Greece since 1995 [12][13][14][15]. In December 2010, we initiated a 6-month longitudinal study among children attending day-care centers in Athens and the nearby prefecture of Viotia.…”

Section: Introductionmentioning

confidence: 99%

Dynamics of pneumococcal carriage among day-care center attendees during the transition from the 7-valent to the higher-valent pneumococcal conjugate vaccines in Greece

Grivea¹,

Priftis²,

Giotas³

et al. 2014

Vaccine

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“…1,25 Further beneficial impact of PCVs, beyond reduction of disease and carriage rates was reduction in antibiotic use and in pneumococcal antibiotic resistance. 8,[26][27][28] Evidently, PCV impact on pneumococcal disease and carriage rates depends also on the individually established vaccine efficacy, vaccine uptake, adherence to plans. 29 and potentially vaccine dosing regimens.…”

Section: Introductionmentioning

confidence: 99%

Pneumococcal nasopharyngeal carriage in children <5 years of age visiting the pediatric emergency room in relation to PCV7 and PCV13 introduction in southern Israel

Ben‐Shimol

Givon-Lavi

Greenberg

et al. 2015

Human Vaccines & Immunotherapeutics

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The 7-valent and the 13-valent pneumococcal conjugate vaccines (PCV7 and PCV13, respectively) were introduced to the Israeli National Immunization plan in July 2009 and November 2010, respectively. Our aim was to assess pneumococcal conjugate vaccines (PCVs) uptake and dynamics in serotype-specific pneumococcal nasopharyngeal (NP) carriage in children <5 years old in southern Israel, during the immediate 5 y following PCV introduction. This was an ongoing, prospective, population-based, active surveillance, from July 2009 through December 2014. PCVs uptake and NP cultures were obtained daily from children seen at the Pediatric Emergency Room for any reason. Overall, 10,702 vaccine status and 7,610 NP swabs were obtained. Both PCV7 and PCV13 uptake were high, reaching~90% by July 2012 and December 2013, respectively. All-pneumococcal carriage rates significantly declined by 10%, from 54.3% in the early-PCV7 period, to 49.1% in the PCV13 impact period. The respective declines for PCV7, 6A and additional PCV13 serotypes carriage rates were 76%, 90% and 66%. In contrast, non-PCV13 serotypes carriage rates increased significantly throughout the study by 71%. All-pneumococcal carriage rates in children <12 months old decreased significantly by 15%, with similar trends observed in other age groups. Initially, all-pneumococcal carriage rates were 45.7%, and 61.9% in Jewish and Bedouin children, respectively (P < 0.001), with a significant 17% reduction throughout the study observed only in Bedouins. While early carriage rates were higher in unvaccinated children compared to vaccinated children, PCV impact on carriage were similar in both groups. In conclusion, a relatively moderate decline in pneumococcal carriage rates, facilitated by a substantial decrease of vaccine-serotypes and increase of non-vaccine serotypes was observed in the immediate period following PCVs introduction in southern Israel.

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Impact of Heptavalent Pneumococcal Conjugate Vaccine on Nasopharyngeal Carriage of Penicillin-Resistant Streptococcus pneumoniae Among Day-Care Center Attendees in Central Greece

Abstract: In Central Greece, widespread PCV vaccination was followed by a significant reduction of carriage of highly penicillin-resistant pneumococci. The frequency of penicillin-intermediate isolates did not change significantly among vaccinated carriers.

Cited by 42 publications

References 31 publications

Predisposing factors for acute otitis media in infancy

Predisposing factors for acute otitis media in infancy

Dynamics of pneumococcal carriage among day-care center attendees during the transition from the 7-valent to the higher-valent pneumococcal conjugate vaccines in Greece

Pneumococcal nasopharyngeal carriage in children <5 years of age visiting the pediatric emergency room in relation to PCV7 and PCV13 introduction in southern Israel

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