Impact of hepatitis C virus infection on clinical features, quality of life and survival of patients with lymphoplasmacytoid lymphoma/immunocytoma

Abstract

This study confirms that HCV infection is present in about one-third of patients with Lp-Ic. HCV infection does not seem to affect the overall survival of patients with Lp-Ic, but it affects the clinical expression of the disease, so that the overall quality of life of HCV+ve patients is significantly worse.

Oligoclonal non-neoplastic B cell expansion is the key feature of type II mixed cryoglobulinemia: Clinical and molecular findings do not support a bone marrow pathologic diagnosis of indolent B cell lymphoma

“…Consistent with our present incomplete understanding of the clinicobiologic scenario, type II MC has been considered either as a lowgrade/indolent neoplastic disorder confined to the bone marrow or as an autoimmune and chronic infectious disease (1)(2)(3)(4)(5)(6)(7)(8)(9)(10).…”

“…While pathologic features consistent with IBCL are often detected in the bone marrow at the time of diagnosis of type II MC (3,5,(6)(7)(8)(9)(10)(11), the clinical manifestations, which are typical of a systemic autoimmune and chronic infectious disease and lack neoplastic features even at followup, provide evidence against a neoplastic disorder in the large majority of cases (3,6,12). An overtly neoplastic evolution is observed in a minority of patients with type II MC (Ͻ15%) (6,12), and other adverse events during followup usually affect the mortality and morbidity rates.…”

Qualitative and quantitative analysis of human herpesviruses in chronic and acute B cell lymphocytic leukemia and in multiple myeloma

“…3,4 The neoplastic potential of at least two human herpesviruses with B lymphocyte tropism, Epstein-Barr virus (EBV or HHV-4) and Kaposi's sarcoma herpes virus (KSHV or HHV-8) has been established, especially within the context of treatment with immunosuppressive agents or co-infection with human immunodeficiency virus (HIV). 1,5,6 EBV can induce Hodgkin and Burkitt's lymphoma and immunodeficiency-associated lymphoma observed in AIDS patients and graft recipients.…”

Hepatitis-C-Virus-assoziierte Kryoglobulinämie

“…Die meisten Patienten mit einem follikulären NHL weisen eine bcl-2-Translokation auf und haben einen langsam progredienten klinischen Verlauf. Eine beträchtliche Zahl (15-20%) entwickelt eine Transformation in ein aggressives NHL [79], häufig in Verbindung mit einer Deregulation zusätzlicher Onkogene, wie z.B. c-myc [26].…”