Impact of hepatitis B and delta virus co-infection on liver disease in Mauritania: A cross sectional study

Lunel‐Fabiani, Françoise; Mansour, Waël; Amar, Abdellahi Ould; Aye, Mohamed; Gal, Frédéric Le; Malick, Faryal; Lô, Baïdy; Brichler, Ségolène; Veillon, Pascal; Ducancelle, Alexandra; Gordien, Emmanuel; Rosenheim, M.

doi:10.1016/j.jinf.2013.06.008

Cited by 43 publications

(56 citation statements)

References 36 publications

(40 reference statements)

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“…The rare HDV seroprevalence studies that have been performed during the past 15 years and the recent reports of the African clades 5 to 8 (5,6) als), Gabon (15.6% to 70.6%), Mauritania (14.7% to 33.1%), Mozambique (0%), Nigeria (0% to 12.5%), and Senegal (3.2%), revealed various HDV antibody rates (2,(15)(16)(17)(18)(19)(36)(37)(38)(39)(40). Interestingly, also in our study, the HDV Ab prevalences varied widely and ranged from 0% to 27.3% in asymptomatic carriers and from 1.3% to 50% in liver patients.…”

Section: Discussionmentioning

confidence: 99%

“…Of these, 15 were attributed to these supposedly "African" clades, while 10 strains clustered with clade 1 (5,6). Despite their characterization as African clades, only few genotyping studies have been performed in Africa (Cameroon, clades 1, 5, 6, 7; Gabon, clades 1, 7, and 8; Mauritania, clades 1 and 5), and clade 1 dominated in all cohorts (2,5,6,(15)(16)(17)(18)(19).…”

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confidence: 99%

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Characterization of Hepatitis Delta Virus in Sub-Saharan Africa

et al. 2014

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Hepatitis D virus (HDV) is a satellite of hepatitis B virus (HBV), and infection with this virus aggravates acute and chronic liver disease. While HBV seroprevalence is very high across sub-Saharan Africa, much less is known about HDV in the region. In this study, almost 2,300 blood serum samples from Burkina Faso (n ‫؍‬ 1,131), Nigeria (n ‫؍‬ 974), Chad (n ‫؍‬ 50), and the Central African Republic (n ‫؍‬ 118) were screened for HBV and HDV. Among 743 HBsAg-positive serum samples, 74 were positive for HDV antibodies and/or HDV RNA, with considerable differences in prevalence, ranging from <2% (pregnant women from Burkina Faso) to 50% (liver patients from Central African Republic). HDV seems to be much more common in chronic liver disease patients in the Central African Republic (CAR) than in similar cohorts in Nigeria. In a large nested mother-child cohort in Burkina Faso, the prevalence of HDV antibodies was 10 times higher in the children than in their mothers, despite similar HBsAg prevalences, excluding vertical transmission as an important route of infection. The genotyping of 16 full-length and 8 partial HDV strains revealed clade 1 (17/24) in three of the four countries, while clades 5 (5/24) and 6 (2/24) were, at least in this study, confined to Central Nigeria. On the amino acid level, almost all our clade 1 strains exhibited a serine at position 202 in the hepatitis D antigen, supporting the hypothesis of an ancient African HDV-1 subgroup. Further studies are required to understand the public health significance of the highly varied HDV prevalences in different cohorts and countries in sub-Saharan Africa.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Characterization of Hepatitis Delta Virus in Sub-Saharan Africa

et al. 2014

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“…In Mauritania a prevalence rate of 33.1% among HBsAg positive patients was recently reported, and HDV was associated with more aggressive disease than HBV infection alone (122). Other studies show wide differences in sero-prevalence in HBsAg positive liver patients, ranging from 1.3% in a Nigerian center, to 50% in Central African Republic and 66% in Gabon (123,124).…”

Section: The Case Of Low Endemicity Regionsmentioning

confidence: 96%

Hepatitis delta virus: From biological and medical aspects to current and investigational therapeutic options

2015

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“…However, it is of worthy to note that in the two previous studies, HIV& HBV co-infected patients were exclusively reported while only two HIV&HBV co-infected patients were found in the present study. In other studies elsewhere in Africa, prevalence varied from 0-50% was reported without any clear explanation on these variations [12][13][14]. In two previous studies carried out in the northern part of Benin, Zanchetta et al [7] reported 19.4% prevalence rate for anti-HDV antibodies while a rate of 11.4% was reported by de Paschale et al some years later [8].…”

Section: Discussionmentioning

confidence: 94%

Hepatitis C, Delta and Human Immunodeficiency Virus Sero-Prevalence in Patients Chronically Infected with Hepatitis B Virus in Cotonou, Benin

Affolabi

Kpossou

Sogbo

et al. 2017

JHVRV

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Infections with hepatitis viruses are known to be prevalent in sub-Saharan Africa but in Benin, data on these infections are still scarce. The study was carried out to assess the burden of these infections in Cotonou. From June to October 2016, we conducted a cross-sectional study on 156 Hepatitis B Virus (HBV) infected patients attending the University Teaching Hospital and a private hospital in Cotonou. For each patient, HBV viral load measurement and Hepatitis Delta Virus (HDV), Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) serology tests were performed using standard methods. The median HBV viral load was 557.5 UI/mL and HDV, HCV and HIV sero-prevalence rates were 3.9%, 1.3% and 0.7% respectively. In conclusion, in HBV infected patients in Cotonou, the sero-prevalence rates of HDV, HCV and HIV were relatively low. A national prevalence survey is needed to assess the epidemiology of these infections in the country.

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Impact of hepatitis B and delta virus co-infection on liver disease in Mauritania: A cross sectional study

Abstract: In Mauritania, HDV co-infection worsens liver disease, both clinically and biologically, as confirmed by the APRI and FibroMeter tests. These tests may be useful for the management of delta hepatitis, which is a major health problem in Mauritania.

Cited by 43 publications

References 36 publications

Characterization of Hepatitis Delta Virus in Sub-Saharan Africa

Characterization of Hepatitis Delta Virus in Sub-Saharan Africa

Hepatitis delta virus: From biological and medical aspects to current and investigational therapeutic options

Hepatitis C, Delta and Human Immunodeficiency Virus Sero-Prevalence in Patients Chronically Infected with Hepatitis B Virus in Cotonou, Benin

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