Impact of hematopoietic cell transplant frailty scale on transplant outcome in adults

Salas, María Queralt; Atenafu, Eshetu G.; Pašić, Ivan; Al-Shaibani, Eshrak; Bascom, Ora; Wilson, L. N.; Chen, Carol; Law, Arjun; Lam, Wilson; Novitzky‐Basso, Igor; Kim, Dennis Dong Hwan; Gerbitz, Armin; Viswabandya, Auro; Michelis, Fotios V.; Lipton, Jeffrey H.; Mattsson, Jonas; Alibhai, Shabbir M.H.; Kumar, Rajat

doi:10.1038/s41409-022-01892-3

Cited by 7 publications

(6 citation statements)

References 39 publications

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“…It is therefore important to use reliable, easy to apply and low-cost frailty evaluation protocols to regularly use in clinical practice. The HCT Frailty Scale designed at our Institution satis es all these conditions of reliability and low cost, since it has been demonstrated that can be applied at rst consultation by the existing transplant teams, without the support of Geriatric specialists, and completed in a median of 5-6 minutes (21,22). In addition, considering that frailty has a negative effect on transplant results, the next step of the research should focus on treating this syndrome with speci c interventions with the ultimate goal of minimizing the negative impact of frailty on transplant outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…The HCT Frailty Scale was designed based on the Frailty and Functionality evaluation results with purpose in mind of classifying patients into t, frail, and pre-frail categories (21,22). Different models of assessment have been proposed to evaluate frailty before HCT (14)(15)(16)(17)(18)20).…”

Section: Discussionmentioning

confidence: 99%

“…The study cohort selected for the conduction of this study integrates into a single sample used to calibrate and validate the HCT Frailty Scale in previous work by the authors (22).…”

Section: Patient Selectionmentioning

confidence: 99%

“…The evaluation was completed in 5-6 minutes and performed by hematologists, clinical fellows, and non-physician specialists such as nurse transplant coordinators. Based on the scores of the eight variables included in the Frailty assessment, a further step in the progress of the frailty program and research was to design and validate the HCT Frailty Scale (Figure 1) (22). This new classi cation method was designed to grade patient candidates for alloHCT into three levels of risk for transplant outcomes (in terms of OS and NRM): t, pre-frail, and frail.…”

Section: Patient Selectionmentioning

confidence: 99%

“…Based on our studies on Frailty evaluation, the Hematopoietic Cell Transplant (HCT) Frailty Scale was developed that allowed the classi cation of alloHCT candidates into one of the three frailty categories: t, pre-frail, and frail. The purpose of the scale was to have pre-transplant indicators of frailty, and to evaluate if the scale could predict transplant outcomes such as overall survival (OS) and nonrelapse mortality (NRM) (22).…”

Section: Introductionmentioning

confidence: 99%

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HCT Frailty Scale for Younger and Older Adults Undergoing Allogeneic Hematopoietic Cell Transplantation

Kumar

Salas

Atenafu

et al. 2023

Preprint

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The HCT Frailty Scale is an easy prognostic tool composed of (a) Clinical Frailty Scale; (b) Instrumental Activities of Daily Living; (c) Timed-up-and-Go test; (d) Grip Strength; (e) Self-Health Rated Questionnaire; (f) Falls tests; (g) Albumin and C-reactive protein levels. This scale was designed to classify allogeneic hematopoietic cell transplant (alloHCT) candidates into fit, pre-frail and frail groups, irrespective of age. This study evaluates the ability of this frailty classification to predict overall survival (OS) and non-relapse mortality (NRM) in adult patients of all ages, in a prospective sample of 298 patients transplanted between 2018 and 2020. At first consultation, 103 (34.6%) patients were fit, 148 (49.7%) pre-frail, and 47 (15.8%) were frail. The 2-year OS and NRM of the three groups were 82.9%, 67.4%, and 48.3% (P<0.001), and 5.4%, 19.2%, and 37.7% (P<0.001). For patients younger than 60 years (n=174), the 2-year OS and NRM of fit, pre-frail, and frail groups were 88.4%, 69,3% and 53.1% (P=0.002), and 5.8%, 22,8%, and 34.8% (P=0.005), respectively; and in patients older than 60 (n=124), OS and NRM were 75.5%, 63.8% and 41.4% (P=0.006), and 4.9%, 16.4%, and 42.1% (P=0.001). In conclusion, frailty predicted worse transplant outcomes in both younger and older adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The study cohort selected for the conduction of this study integrates into a single sample used to calibrate and validate the HCT Frailty Scale in previous work by the authors (22).…”

Section: Patient Selectionmentioning

confidence: 99%

Section: Patient Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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