Impact of H. Pylori on Growth: Is the Infection or Mucosal Disease Related to Growth Impairment?

Gülcan, Mahir; Ozen, Ahmet; Karatepe, Hande Özgün; Gülcü, Didem; Vitrinel, Ayça

doi:10.1007/s10620-009-1091-y

Cited by 25 publications

(30 citation statements)

References 29 publications

(38 reference statements)

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“…Because of this, FEV 1 is height dependent 14. In the present study, the mean difference in height between the seropositive and seronegative individuals was 0.012 m. Our data are in keeping with a large body of literature demonstrating that chronic infection with this bacterium impairs growth during childhood, which manifests as shorter adult height 15 16. One study found that the average difference in height between H. pylori positive and negative individuals was 0.035 m 16.…”

Section: Discussionsupporting

confidence: 89%

The relationship betweenHelicobacter pyloriseropositivity and COPD

Sze

Chen

Tam

et al. 2015

Thorax

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Section: Discussionsupporting

confidence: 89%

The relationship betweenHelicobacter pyloriseropositivity and COPD

Sze

Chen

Tam

et al. 2015

Thorax

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“…Moreover, in adults, HP eradication has been shown to be followed by weight gain [19, 37]. In contrast, some reports have indicated that HP-related gastric symptoms, not HP infection itself, induce malnutrition [16, 38]. While the effect of this phenomenon on our conclusions cannot be quantified at the moment, our observation that low HP infection, and not negative HP infection status, is associated with the lowest risk of MetS might be explained by the inverse effect of HP infection and associated gastric symptoms on overnutrition.…”

Section: Discussionmentioning

confidence: 99%

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

et al. 2016

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BackgroundHelicobacter pylori (HP) infection is implicated in gastric and extra-gastric diseases. While gastritis-related chronic inflammation represents a known trigger of metabolic disturbances, whether metabolic syndrome (MetS) is affected by gastritis status remains unclear. We aimed to clarify the effect of HP-related gastritis on the risk of MetS.Materials and MethodsWe retrospectively enrolled patients undergoing screening for MetS between 2014 and 2015. Investigations included HP-specific immunoglobulin G (IgG) antibody assays to detect HP infection, and serum pepsinogen assays to evaluate atrophic gastritis status. The risk of MetS was evaluated via multiple logistic regression analyses with two covariates: serum HP infection status (IgG levels) and atrophic gastritis status (two criteria were applied; pepsinogen I/II ratio < 3 or both pepsinogen I levels ≤ 70 μg/L and pepsinogen I/II ratio < 3).ResultsOf 1,044 participants, 247 (23.7%) were HP seropositive, and 62 (6.0%) had MetS. HP seronegative and seropositive patients had similar risks of MetS. On the other hand, AG (defined in terms of serum PG I/II <3) was significant risk of MetS (OR of 2.52 [95% CI 1.05–7.52]). After stratification according to HP IgG concentration, patients with low HP infection status had the lowest MetS risk (defined as an odds ratio [OR] adjusted for age, sex, smoking, drinking and physical activity status). Taking this result as a reference, patients with negative, moderate, and high HP infection status had ORs (with 95% confidence intervals [CI]) of 2.15 (1.06–4.16), 3.69 (1.12–16.7), and 4.05 (1.05–26.8).ConclusionsHP-associated gastritis represents a risk factor for MetS. Research should determine why low and not negative HP infection status is associated with the lowest MetS risk.

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“…An apparent negative impact of H. pylori infection on growth velocity or height has been documented in cohort studies in infants 6,7,8 and school age children 9 , as well in several well designed cross-sectional studies 10,11,12 . Although the amount and quality of the evidence seems to support the association of H. pylori infection and growth, it is not known whether attained height and weight in children will be impacted over the long term.…”

Section: Introductionmentioning

confidence: 90%

Long-term Effects of Clearing Helicobacter pylori on Growth in School-age Children

Mera¹,

Bravo²,

Goodman³

et al. 2012

Pediatric Infectious Disease Journal

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Background A new H. pylori infection affects growth velocity negatively, and clearing the infection produces a small significant rebound, but it is not known whether height and weight in children are impacted over the long term. Methods We investigated 295 school-age children followed in two cohorts, one treated (150) and one untreated (145), from 2004 for 3.7 years with 1105 child-years of observation. Follow-up intervals were 3 months for anthropometry measurements and 6 months for H. pylori status ascertained by urea breath test. Height in centimeters and weight in kilograms were analyzed using growth models. Results A multivariate mixed model that adjusted for age, sex, father’s education and number of siblings found no significant differences in height or weight at baseline by H. pylori status. The same model showed a significant impact of clearing H. pylori across time, with increasing significant differences in average height and weight as the follow-up progressed. Conclusions Children who were always negative or who cleared the infection grew significantly faster than those who stayed positive after adjusting for other covariates. This study suggests that school age children’s growth benefits from being treated for H. pylori infection.

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Impact of H. Pylori on Growth: Is the Infection or Mucosal Disease Related to Growth Impairment?

Abstract: Recurrent abdominal pain associated with gastric mucosal injury plays a role in a decrease in BMI independent of H. pylori infection. However, if recurrent abdominal pain originates from H. pylori infection, it appears that linear growth is also affected.

Cited by 25 publications

References 29 publications

The relationship betweenHelicobacter pyloriseropositivity and COPD

The relationship betweenHelicobacter pyloriseropositivity and COPD

Impact of Helicobacter pylori Immunoglobulin G Levels and Atrophic Gastritis Status on Risk of Metabolic Syndrome

Long-term Effects of Clearing Helicobacter pylori on Growth in School-age Children

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