Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference

Abstract

Dyslipidemia (DL) is one of the most common lifestyle-related diseases. There are few reports showing the causal relationship between gut microbiota (GM) and DL. In the present study, we used a linear non-Gaussian acyclic model (LiNGAM) to evaluate the causal relationship between GM and DL. A total of 79 men and 82 women aged 40 years or older living in Shika-machi, Ishikawa Prefecture, Japan were included in the analysis, and their clinical information was investigated. DNA extracted from the GM was processed to sequence the 16S rRNA gene using next-generation sequencing. Participants were divided into four groups based on sex and lipid profile information. The results of one-way analysis of covariance, linear discriminant analysis effect size, and least absolute value reduction and selection operator logistic regression model indicated that several bacteria between men and women may be associated with DL. The LiNGAM showed a presumed causal relationship between different bacteria and lipid profiles in men and women. In men, Prevotella 9 and Bacteroides were shown to be potentially associated with changes in low- and high-density lipoprotein cholesterol levels. In women, the LiNGAM results showed two bacteria, Akkermansia and Escherichia/Shigella, had a presumptive causal relationship with lipid profiles. These results may provide a new sex-based strategy to reduce the risk of developing DL and to treat DL through the regulation of the intestinal environment using specific GM.

Genetically predicted gut microbiota mediate the association between plasma lipidomics and primary sclerosing cholangitis

“…PSC is closely related to the intestine. With the emergence of the “leaky gut” hypothesis and the “PSC microbiome” hypothesis, the gut microbiota as a potential pathogenic factor for PSC has received increasing attention [ 13 , 15 , 16 ]. In this study, we identified that the gut microbe Eubacterium rectale can act as a mediator to facilitate the occurrence and progression of PSC by mediating PC O-16:1_18:1.…”

“…Recently, with the emergence of the “leaky gut” hypothesis and the “PSC microbiome” hypothesis, the gut microbiota has attracted increasing attention as a potential pathogenic factor for PSC [ 13 – 15 ]. Not only that, but changes in blood lipids have been found to be closely related to the abundance of the gut microbiota [ 16 – 19 ]. Consequently, the gut microbiota composition might serve as potential mediators between lipidomics and PSC.…”

Prediction and causal inference of hyperuricemia using gut microbiota

“…Fecal samples were collected from 488 participants using the method described previously 29 . The stool surface samples were collected independently by the participants using clean paper (AZ-ONE, Osaka, Japan) and a clean spatula with a plastic tube (AZ-ONE, Japan).…”

Gut Microbiota and Microbial Metabolism in Early Risk of Cardiometabolic Disease

“…Observational studies have identified potential relationships between gut microbiota and circulating lipids and lipoproteins, [250][251][252][253][254] with microbiota accounting for an estimated 4% to 6% of the variation in triglyceride and HDL (high-density lipoprotein) cholesterol 255 and individual microbiota associating with specific lipoprotein subclasses in obese individuals. 256 Gut microbiota may affect lipid metabolism directly through modulation of lipids within the gut and systemically, 257 with gut microbial production of SCFAs serving as the precursor for hepatic synthesis of longer chain monounsaturated fatty acids and glycerophospholipids.…”