Impact of Gold Nanoparticles on Colon Cancer Treatment and Diagnosis

Khan, Firdos Alam; Aldahhan, Razan; Almohazey, Dana

doi:10.2217/nnm-2021-0043

Cited by 7 publications

(6 citation statements)

References 29 publications

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“…Additionally, the final BNC UV visible spectroscopy results displayed characteristic lowered ZnPcS 4 PS signature peaks at 340 nm and 674 nm wavelength regions, suggesting that even though some quenching and aggregation occurred, it should still be able to effectively function within PDD and PDT assays [8,19]. Lastly, the final BNC UV visible spectroscopy results revealed the presence of the signature 520 nm PEGlated AuNPs band, suggesting that the NPs photothermal function remained intact and was able to contribute to PDTinduced annihilation of CRCs [51]. DLS and ZP characterization results of the final BNC reported high stability and monomodal particle size distribution patterns, suggesting it was stable and small enough to be accepted as an active nano-drug carrying platform [24][25][26][27].…”

Section: Discussionmentioning

confidence: 96%

“…Thus, in relation to the treatment of cancer through tumor detection, drug delivery, imaging, photothermal, and photodynamic therapy, AuNPs are most definitely utilizable nanocarriers within research investigations. Recent studies by Khan et al (2021) reported the successful application of AuNPs for the phototreatment and diagnosis of CRC, however, they noted that the study's outcomes could be improved upon if the AuNPs were further modified with CRC bio-targeting markers [51].…”

Section: Discussionmentioning

confidence: 99%

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Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer

Simelane

Kruger

Abrahamse

2021

IJMS

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Colorectal cancer (CRC) is an aggressive cancer that remains a challenge to diagnose and treat. Photodynamic diagnosis (PDD) and therapy (PDT) are novel alternative techniques, which can enhance early diagnosis, as well as elicit tumor cell death. This is accomplished through photosensitizer (PS) mediated fluorescence and cytotoxic reactive oxygen species activation upon laser light irradiation excitation at specific low and high range wavelengths, respectively. However, the lack of PS target tumor tissue specificity often hampers these techniques. This study successfully fabricated a bioactive nanoconjugate, ZnPcS4-AuNP-S-PEG5000-NH2-Anti-GCC mAb (BNC), based upon a polyethylene glycol-gold nanoparticle, which was multi-functionalized with a fluorescent PDT metalated zinc phthalocyanine PS, and specific anti-GCC targeting antibodies, to overcome CRC PDD and PDT challenges. The BNC was found to be stable and showed selectively improved subcellular accumulation within targeted CRC for improved PDD and PDT outcomes in comparison to healthy in vitro cultured cells. Additionally, the BNC reported significantly higher late apoptotic PDT-induced CRC cell death rates (34% ***) when compared to PDT PS administration alone (15% *). These results indicated that the improved PDD and PDT outcomes were due to the specific PS accumulation in CRC cells through nanoparticle carriage and bioactive anti-GCC targeting.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer

Simelane

Kruger

Abrahamse

2021

IJMS

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“…One of the most aggressive types of cancer is colorectal or colon cancer. It is the third most common cancer and a significant cause of morbidity and mortality worldwide [ 5 ]. We report a case of an obturator hernia with colon cancer, which has not been reported previously.…”

Section: Introductionmentioning

confidence: 99%

Intestinal obstruction, obturator hernia, and/or colonic neoplasms: a case study

Jin,

Lai

2023

Journal of Surgical Case Reports

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Occlusive hernias are rare and difficult to diagnose. We present an extraordinary case of simultaneous occurrence of an obturator hernia with colon cancer. An 86-year-old woman arrived at the hospital after ˃2 weeks of abdominal pain, nausea, vomiting, and constipation. The computed tomography axis map showed that part of the right lower abdominal small intestine had intruded into the femoral triangle through the obturator, which was diagnosed as an obturator hernia. When the abdominal cavity was opened for herniorrhaphy, a 4 × 4 cm colon mass was observed. Only herniorrhaphy was performed, without any complications. At present, there has been no report of the coexistence of occlusive hernia and colon cancer; the main symptoms are intestinal obstruction, nausea, vomiting, and constipation. The decision whether the tumor should be removed simultaneously with herniorrhaphy and/or a mesh patch.

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“…CRC affects the epithelial cells that line the colon’s lumen and is progressively classified depending on the depth of invasion of original cancer, the involvement of lymph node metastasis, and the existence of distant metastasis. Therefore, CRC treatment and the corresponding therapeutic approaches depend on the tumor features and the patient response [ 1 , 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Controlled-Release Nanosystems with a Dual Function of Targeted Therapy and Radiotherapy in Colorectal Cancer

et al. 2022

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Nanoparticles are excellent platforms for several biomedical applications, including cancer treatment. They can incorporate different molecules to produce combinations of chemotherapeutic agents, radionuclides, and targeting molecules to improve the therapeutic strategies against cancer. These specific nanosystems are designed to have minimal side effects on healthy cells and better treatment efficacy against cancer cells when compared to chemotherapeutics, external irradiation, or targeted radiotherapy alone. In colorectal cancer, some metal and polymeric nanoparticle platforms have been used to potentialize external radiation therapy and targeted drug delivery. Polymeric nanoparticles, liposomes, albumin-based nanoparticles, etc., conjugated with PEG and/or HLA, can be excellent platforms to increase blood circulation time and decrease side effects, in addition to the combination of chemo/radiotherapy, which increases therapeutic efficacy. Additionally, radiolabeled nanoparticles have been conjugated to target specific tissues and are mainly used as agents for diagnosis, drug/gene delivery systems, or plasmonic photothermal therapy enhancers. This review aims to analyze how nanosystems are shaping combinatorial therapy and evaluate their status in the treatment of colorectal cancer.

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Impact of Gold Nanoparticles on Colon Cancer Treatment and Diagnosis

Cited by 7 publications

References 29 publications

Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer

Targeted Nanoparticle Photodynamic Diagnosis and Therapy of Colorectal Cancer

Intestinal obstruction, obturator hernia, and/or colonic neoplasms: a case study

Controlled-Release Nanosystems with a Dual Function of Targeted Therapy and Radiotherapy in Colorectal Cancer

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