Impact of Glucose Tolerance Status on Development of Ischemic Stroke and Coronary Heart Disease in a General Japanese Population

Abstract

Background and Purpose-Few studies have shown the association between glucose tolerance status defined by a 75-g oral glucose tolerance test and the development of different types of cardiovascular disease. Methods-A total of 2421 community-dwelling Japanese subjects aged 40 to 79 years who underwent the oral glucose tolerance test were followed up for 14 years. Results-In multivariable analysis, the risks of ischemic stroke in both sexes and coronary heart disease (CHD) in women were significantly higher in subjects with diabetes determined by the World Health Organization criteria than in those with normal glucose tolerance even after adjustment for other confounding factors, but such association was not seen for CHD in men (ischemic stroke: adjusted hazard ratio

The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study

“…To our knowledge, this study is the first on the combined impact of these borderline risk factors, IFG and prehypertension on the incidence of CVD in a general Asian population. Previous cohort studies have shown that DM is a risk factor for CVD, stroke 14,15 and CHD. 13 The results of our study are also essentially compatible with the previous cohort studies in Japan.…”

“…The Hisayama Study demonstrated that glucose intolerance for 2421 participants was a risk factor for increased incidence of stroke and CHD. 15 Iso et al 20 reported that glucose abnormalities were a risk factor for ischemic stroke in a Japanese population by using nonfasting glucose levels. The NIPPON DATA 80 Study indicated that DM, defined by nonfasting blood glucose levels, was a risk factor for CVD mortality.…”

“…First, our cohort population was relatively large and was selected at random from an urban population in contrast to most other cohort populations in Asia, which were selected from rural populations. 15,20,34 Second, all of our cohort participants were examined at one place and measured using the same autoanalyzer at one laboratory. Finally, our study examined the risk of CVD incidence, not CVD mortality.…”

“…9,10 Diabetes mellitus (DM) has become a major public health problem 11,12 as well as a risk factor for all-cause mortality 11 and CVD. 10,[13][14][15] Recently, prediabetic hyperglycemia has been recognized to confer an increased risk for CVD. 16 However, a few population studies 17 have reported a positive association between CVD and impaired fasting glucose (defined as blood glucose of 5.6-6.9 mmol l À1 according to the 2003 American Diabetes Association definition).…”

Risk of hospitalization for diabetic macrovascular complications and in‐hospital mortality with irregular physician visits using propensity score matching

“…In Japan, DM was reported as a risk factor for cardiovascular disease and coronary heart disease6, and DM is related to coronary heart disease among women and ischemic stroke among both sexes7. In addition, large nationwide cohort studies in Japan have suggested that DM and elevated glucose levels are associated with incident coronary heart disease8 and ischemic stroke9 in the general Japanese population.…”