Impact of glucose and acetate on the characteristics of the platelet storage lesion in platelets suspended in additive solutions with minimal plasma

Saunders, C.; Rowe, G. P.; Wilkins, Kenneth J.; Collins, Peter William

doi:10.1111/vox.12013

Cited by 32 publications

(35 citation statements)

References 43 publications

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“…The shelf-life of platelets stored at RT is limited due to the risk of bacterial growth and contamination, which can cause life-threatening transfusion-related infections [108]. Additionally, platelets stored at RT gradually deteriorate and undergo a decline in hemostatic and metabolic function, which is known collectively as the platelet storage lesion [109–112]. …”

Section: Quality Of Platelet Concentratesmentioning

confidence: 99%

Quality Assessment of Established and Emerging Blood Components for Transfusion

Acker

Marks

Sheffield

2016

Journal of Blood Transfusion

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Blood is donated either as whole blood, with subsequent component processing, or through the use of apheresis devices that extract one or more components and return the rest of the donation to the donor. Blood component therapy supplanted whole blood transfusion in industrialized countries in the middle of the twentieth century and remains the standard of care for the majority of patients receiving a transfusion. Traditionally, blood has been processed into three main blood products: red blood cell concentrates; platelet concentrates; and transfusable plasma. Ensuring that these products are of high quality and that they deliver their intended benefits to patients throughout their shelf-life is a complex task. Further complexity has been added with the development of products stored under nonstandard conditions or subjected to additional manufacturing steps (e.g., cryopreserved platelets, irradiated red cells, and lyophilized plasma). Here we review established and emerging methodologies for assessing blood product quality and address controversies and uncertainties in this thriving and active field of investigation.

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Section: Quality Of Platelet Concentratesmentioning

confidence: 99%

Quality Assessment of Established and Emerging Blood Components for Transfusion

Acker

Marks

Sheffield

2016

Journal of Blood Transfusion

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“…[13][14][15][16] Glucose is important for maintaining ATP levels and NADPH-reducing equivalents and was shown to be essential for the maintenance of PLTs stored as concentrates with minimal volumes of plasma. 15,[17][18][19] In the past, the development of glucose-containing PASs has been limited by standard steam sterilization techniques that caramelize sugars at pH ranges greater than 5.5. Intersol-G and SSP1 are among the recently developed PASs.…”

Section: Conclusion: Preparation Of Bc-derived Pcs Withmentioning

confidence: 99%

“…Previous studies have used apheresis procedures or an additional centrifugation step to obtain pooled BC-derived PCs with minimal residual plasma. 12,13,15,21,22 In this study, we were able to establish a semiautomated process for the preparation of pooled BC-derived PCs with less than 20% residual plasma under routine production conditions.…”

Section: Conclusion: Preparation Of Bc-derived Pcs Withmentioning

confidence: 99%

In vitro variables of buffy coat–derived platelet concentrates with residual plasma of down to 10% are stably maintained in new‐generation platelet additive solutions

et al. 2015

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“…Although the test unit BRS includes 1·0 mmol/L magnesium chloride to reduce glycolysis, the glucose consumption rates in both units were comparable. In the previous acetate study, glucose was consumed more rapidly in units with no acetate added (Saunders et al, 2013). Therefore, the BRS including no acetate may be associated with unexpected rapid glucose consumption of the test units.…”

mentioning

confidence: 80%