Impact of Genetic Defects on Coronary Atherosclerosis among Turkish Cypriots

Abstract

Age, male sex, diabetes mellitus, hyperlipidemia, triglycerides, HDL, and triglyceride/HDL ratio were significantly associated with (P < .05); LDL (P = .05) and total cholesterol (P = .08) was marginally associated with coronary artery disease in the Turkish Cypriot population. The mutations in the MTHFR [C677T] gene variant were marginally higher in the Turkish Cypriot cohort when compared with the Turkish patients from Turkey (P = .06). No significant direct association of any of the gene variants with coronary artery disease in the Turkish Cypriot cohort could be defined. Several of the genetic variants were associated indirectly with the risk factors for coronary artery disease in Turkish Cypriots. MTHFR [A1298C] was found to be marginally associated with low HDL cholesterol (P = .08). MTHFR [C677] wild-type allele was significantly associated with a decreased rate of high LDL cholesterol (P < .05). The HPA-1 a/b variant was significantly associated with an increased rate of high total cholesterol levels (P < .05). Conclusion: Turkish Cypriot patients with coronary artery disease may be more affected by secondary factors, such as diabetes, hypertension, obesity, and sedentary life style when compared with genetic factors, which may be responsible for coronary artery disease.

Association of two variants C677T and A1298C MTHFR gene polymorphisms with ischemic heart, ischemic stroke and venous thromboembolism diseases in a sample of Arabic Iraqi patients

“…Very recent Iranian study demonstrated the relationship of MTHFR A1298C gene polymorphism, homocysteine level, vitamin B12 and folate levels with coronary artery disease in the Iranian populations; this study concluded that MTHFR A1298C gene polymorphism was associated with coronary artery disease (31). Other study discussed impact of genetic defect on coronary heart failure among Turkish Cypriot patients; which concluded that those patients with atherosclerosis can be more affected by modifiable risk factors such as hypertension, diabetes, obesity, and smoking as well as genetic factors that can be responsible for coronary heart diseases (32).…”

The Correlation of MTHFR SNPs, Homocysteine, and Conventional Risk Predictors with Coronary Artery Disease

“…Age and gender differences (old age and males) in addition to hypertension and diabetes are strongly related with coronary artery disease, acute myocardial infarction (AMI), and fatal outcomes [7,8]. High serum cholesterol levels and dyslipidemia have adverse relation with atherosclerotic plaque disease affecting the carotid and coronary vasculature [9][10][11]. Metabolic syndrome is associated with higher body mass index (BMI), dyslipidemia, hypertension, and angiographically documented coronary lesions [12].…”