Impact of Gender on Symptoms and Comorbidities in Obstructive Sleep Apnea

Bostan, Özge Can; Akcan, Beyza; Saydam, Cihan Durmus; Tekın, Muhammet; Daşçı, Ömür; Balcan, Baran

doi:10.5152/eurasianjmed.2021.19233

Cited by 9 publications

(7 citation statements)

References 24 publications

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“…Sleepiness can be defined as an inability to maintain wakefulness and alertness during the day [16]. It is associated with a loss of alertness and is considered to be a consequence of sleep fragmentation and adversely affects functioning, mood, cognition, productivity, and quality of life [18,19]. It affects a large part of the population and usually increases the risk of accidents.…”

Section: Discussionmentioning

confidence: 99%

Karolinska Sleepiness Scale is not Associated with Obstructive Sleep Apnea Severity Indices in Male Taxi Drivers

Çelik

2023

Eur J Ther

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Objective: In the current study, we aimed to evaluate the diagnostic utility of the Karolinska Sleepiness Scale (KSS) for obstructive sleep apnea (OSA) in taxi drivers. Methods: Forty male professional taxi drivers who participated in a driving simulator experiment in the sleep laboratory were included in the current study. All participants were asked to fill out the KSS before and after a 50-minute driving simulator task in the morning after overnight polysomnography (PSG) in the hospital. OSA was defined as an apnea-hypopnea-index (AHI) 15 events/hour on the PSG. Excessive daytime sleepiness (EDS) was defined as KSS score of at least 6. Results: In all, only 3 cases fulfilled the criteria for EDS before the driving whereas 13 cases were sleepy after the task was completed (p <0.001). No significant association was found between KSS scores after the task and the PSG variables including total sleep time, time spent in delta sleep and REM sleep as well as OSA severity indices AHI and Oxygen Desaturation Index (ODI). The agreement between OSA and sleepiness on the KSS was calculated as 0.21 (p=0.07) indicating a very weak association. The KSS has a sensitivity of 24.1%, a specificity of 45.5%, a positive predictive value of 53.9%, a negative predictive value of 30.0%, an accuracy of 46.6% for the OSA diagnosis. The area under the curve was 0.57 (95% CI 0.39 – 0.74) for the AHI and 0.56 (95% CI 0.39 – 0.73) for the ODI, confirming a very poor performance of the KSS scores to predict AHI and ODI. Conclusion: The KSS is not associated with the severity of the OSA indices in male taxi drivers. Objective measurements of EDS are warranted for a more precise evaluation of fitness to drive in professional drivers.

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Section: Discussionmentioning

confidence: 99%

Karolinska Sleepiness Scale is not Associated with Obstructive Sleep Apnea Severity Indices in Male Taxi Drivers

Çelik

2023

Eur J Ther

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“…This correlation highlights the need for integrated public health strategies that address both obesity and OSA as interconnected health issues. Gender differences in OSA prevalence are also notable [3,8]. Traditionally, OSA has been viewed as a predominantly male disorder.…”

Section: Obstructive Sleep Apnea: a Chronic Condition With Significan...mentioning

confidence: 99%

“…The significance of these disorders extends beyond the realm of sleep medicine, emerging as critical components in the broader public health dialogue. This is especially true considering the escalating prevalence of obesity and aging populations worldwide, factors that are intrinsically linked with OSA [3]. The burgeoning evidence linking OSA with a myriad of cardiovascular complications underscores the necessity of a comprehensive understanding of this condition [4].…”

Section: Introductionmentioning

confidence: 99%

Obstructive Sleep Apnea and Pulmonary Hypertension: A Chicken-and-Egg Relationship

Balcan,

Akdeniz,

Peker

et al. 2024

JCM

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Obstructive sleep apnea (OSA) is characterized by repeated episodes of upper airway obstruction during sleep, and it is closely linked to several cardiovascular issues due to intermittent hypoxia, nocturnal hypoxemia, and disrupted sleep patterns. Pulmonary hypertension (PH), identified by elevated pulmonary arterial pressure, shares a complex interplay with OSA, contributing to cardiovascular complications and morbidity. The prevalence of OSA is alarmingly high, with studies indicating rates of 20–30% in males and 10–15% in females, escalating significantly with age and obesity. OSA’s impact on cardiovascular health is profound, particularly in exacerbating conditions like systemic hypertension and heart failure. The pivotal role of hypoxemia increases intrathoracic pressure, inflammation, and autonomic nervous system dysregulation in this interplay, which all contribute to PH’s pathogenesis. The prevalence of PH among OSA patients varies widely, with studies reporting rates from 15% to 80%, highlighting the variability in diagnostic criteria and methodologies. Conversely, OSA prevalence among PH patients also remains high, often exceeding 25%, stressing the need for careful screening and diagnosis. Treatment strategies like continuous positive airway pressure (CPAP) therapy show promise in mitigating PH progression in OSA patients. However, this review underscores the need for further research into long-term outcomes and the efficacy of these treatments. This review provides comprehensive insights into the epidemiology, pathophysiology, and treatment of the intricate interplay between OSA and PH, calling for integrated, personalized approaches in diagnosis and management. The future landscape of OSA and PH management hinges on continued research, technological advancements, and a holistic approach to improving patient outcomes.

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“…OSA is independently linked with lower urinary tract symptoms, of which nocturia is the most frequent manifestation ( 88-91 ). Nocturia affects nearly 70% of women and 52% of men with OSA ( 91 , 92 ). In severe OSA cases, the prevalence rises to 82% ( 92 ).…”

Section: Pathophysiology and Associations Of Osa With Other Disordersmentioning

confidence: 99%

Approach the Patient With Obstructive Sleep Apnea and Obesity

Meyer,

Wittert

2023

The Journal of Clinical Endocrinology &Amp; Metabolism

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Obstructive sleep apnoea (OSA) and obesity are highly prevalent and bidirectionally associated. OSA is however underrecognized, particularly in women. By mechanisms that overlap with those of obesity, OSA increases the risk of developing, or having poor outcomes from, comorbid chronic disorders and impairs quality of life. Using two illustrative cases we discuss the relationships between OSA and obesity with type 2 diabetes, dyslipidemia, cardiovascular disease, cognitive disturbance, mood disorders, lower urinary tract symptoms, sexual function, and reproductive disorders. The differences in OSA between men and women, the phenotypic variability of OSA, and co-morbid sleep disorders are highlighted. When the probability of OSA is high due to consistent symptoms, comorbidities, or both, a diagnostic sleep study is advisable. Continuous positive airway pressure or mandibular advancement splints improve symptoms. Benefits for comorbidities are variable depending on nightly duration of use. By contrast weight loss and optimization of lifestyle behaviors are consistently beneficial.

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Impact of Gender on Symptoms and Comorbidities in Obstructive Sleep Apnea

Cited by 9 publications

References 24 publications

Karolinska Sleepiness Scale is not Associated with Obstructive Sleep Apnea Severity Indices in Male Taxi Drivers

Karolinska Sleepiness Scale is not Associated with Obstructive Sleep Apnea Severity Indices in Male Taxi Drivers

Obstructive Sleep Apnea and Pulmonary Hypertension: A Chicken-and-Egg Relationship

Approach the Patient With Obstructive Sleep Apnea and Obesity

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