Impact of Gender and Menopausal Status on Relationships Between Biological Aging, as Indexed by Telomere Length, and Aortic Stiffness

Raymond, Andrew; Norton, Gavin R.; Woodiwiss, Angela J.; Brooksbank, Richard

doi:10.1093/ajh/hpu212

Cited by 13 publications

(14 citation statements)

References 34 publications

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“…This is in agreement with the results of recent publication by Raymond and colleagues [33]. Central hemodynamic parameters—specifically rAI, central BP, and PP—could change by various conditions such as treatment, pulse rate, or vascular stiffness at the time of measurements.…”

Section: Discussionsupporting

confidence: 93%

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Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk

et al. 2017

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IntroductionShort telomere length has been suggested to be associated with atherosclerotic changes in Western populations. We examined the relationships between leukocyte telomere length and cardiovascular and renal function in a Japanese cohort.Participants and methodsWe enrolled 770 subjects who each had at least one cardiovascular risk factor. The mean age was 59.5 ± 12.2 years; mean BMI was 25.1 ± 4.6 kg/m2. We measured leukocyte telomere length (LTL) by quantitative PCR (T/S ratio), and measured other biomarkers from blood and urine samples. In addition, we assessed surrogate markers of arterial stiffness, cardiovascular organ damage and kidney function, including flow-mediated vasodilation (FMD), pulse wave velocity (PWV), carotid artery augmentation index (CAAI), and urinary albumin creatinine ratio (UACR) and eGFR.ResultsLeukocyte telomere length (T/S ratio) was inversely associated with age (r = -0.194, P<0.001), and was lower in men (1.13 ± 0.29%) than in women (1.20 ± 0.31%, P = 0.002). T/S ratio was positively associated with BMI in women (r = 0.11, P = 0.047), but not in men. LTL did not show a significant relationship to cardiovascular surrogate markers, including arterial stiffness, FMD, and PWV, but did show some relationship to CAAI, which was inversely associated with T/S ratio only in men (r = -0.159, P = 0.015). LTL did show a significant positive association with renal function measured by eGFR (r = 0.16, P<0.001) both in men and women.ConclusionsIn this Japanese sample of persons with increased cardiovascular risk, telomere length showed a relationship of longer telomere length to better renal function, but did not overall show convincing association with cardiovascular measures of arterial stiffness and target organ damage.

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Section: Discussionsupporting

confidence: 93%

“…In a study of persons of African descent, significant relationship between LTL and aortic stiffness was observed in both genders, but was also seen in premenopausal women. [33]. It is possible that telomere length in white blood cells may change in parallel with that of vascular cells [34].…”

Section: Discussionmentioning

confidence: 99%

Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk

et al. 2017

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“…Fourth, we did not include systolic blood pressure (SBP) in our regression analyses to avoid introducing collinearity in the models. Similarly, we did not include measures of dietary or exercise, which both have been found to have beneficial effects on cognition 35 , as recent studies have reported a significant impact of these non-drug interventions on arterial stiffness by several mechanisms 36 .…”

Section: Discussionmentioning

confidence: 99%

Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study

Maillard¹,

Mitchell

Himali

et al. 2016

Stroke

101

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Background and Purpose Previous work from the Framingham Heart Study suggests that brain changes due to arterial aging may begin in young adulthood and that such changes precede cognitive deficits. The objective of this study was to determine the association of arterial stiffness with measures of white matter and gray matter integrity in young adults. Methods 1903 participants from the Framingham Heart Study Third Generation (mean age, 46±8.7 years) had complete tonometry measurements and brain MRI (T1-weighted and DTI). Tonometry measures included carotid-femoral pulse wave velocity (CFPWV), augmentation index, carotid-brachial pressure amplification and central pulse pressure. Fractional anisotropy (FA) and gray matter (GM) density images were computed from DTI and T1 images. Registration to a common anatomical template enabled voxel-based linear regressions relating measures of FA and GM to tonometry measures, adjusting for relevant covariables. Results Higher CFPWV was associated with lower regional FA, including the corpus callosum and the corona radiata (8.7 and 8.6cc respectively, p<0.001), as well as lower GM density in the thalamus region (0.9cc, p<0.001). Analyses did not reveal significant associations between other tonometry measures and FA or GM. Conclusions Among young healthy adults, higher aortic stiffness was associated with measures of reduced WM and GM integrity in areas implicated in cognitive decline and Alzheimer's disease. Greater aortic stiffness may result in subclinical vascular brain injury at ages much younger than previously described.

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“…Other measures of body condition that were not measured, however, could still act as potential confounding factors. Further, as some of our qPCR reaction efficiencies were slightly lower than other studies that used qPCR to quantify TL [85,86], the results should be taken with caution.…”

Section: Discussionmentioning

confidence: 70%

Child mortality, hypothalamic-pituitary-adrenal axis activity and cellular aging in mothers

et al. 2017

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Psychological challenges, including traumatic events, have been hypothesized to increase the age-related pace of biological aging. Here we test the hypothesis that psychological challenges can affect the pace of telomere attrition, a marker of cellular aging, using data from an ongoing longitudinal-cohort study of Kaqchikel Mayan women living in a population with a high frequency of child mortality, a traumatic life event. Specifically, we evaluate the associations between child mortality, maternal telomere length and the mothers’ hypothalamic-pituitary-adrenal axis (HPAA), or stress axis, activity. Child mortality data were collected in 2000 and 2013. HPAA activity was assessed by quantifying cortisol levels in first morning urinary specimens collected every other day for seven weeks in 2013. Telomere length (TL) was quantified using qPCR in 55 women from buccal specimens collected in 2013. Results: Shorter TL with increasing age was only observed in women who experienced child mortality (p = 0.015). Women with higher average basal cortisol (p = 0.007) and greater within-individual variation (standard deviation) in basal cortisol (p = 0.053) presented shorter TL. Non-parametric bootstrapping to estimate mediation effects suggests that HPAA activity mediates the effect of child mortality on TL. Our results are, thus, consistent with the hypothesis that traumatic events can influence cellular aging and that HPAA activity may play a mediatory role. Future large-scale longitudinal studies are necessary to confirm our results and further explore the role of the HPAA in cellular aging, as well as to advance our understanding of the underlying mechanisms involved.

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Impact of Gender and Menopausal Status on Relationships Between Biological Aging, as Indexed by Telomere Length, and Aortic Stiffness

Cited by 13 publications

References 34 publications

Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk

Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk

Effects of Arterial Stiffness on Brain Integrity in Young Adults From the Framingham Heart Study

Child mortality, hypothalamic-pituitary-adrenal axis activity and cellular aging in mothers

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