Impact of gender and dialysis modality on early mortality risk in diabetic ESRD patients: data from a large single center cohort

Serafinceanu, C; Neculaescu, Cristian; Cimponeriu, Danut; Timar, Romulus; Covic, Adrian

doi:10.1007/s11255-013-0589-6

Cited by 7 publications

(21 citation statements)

References 30 publications

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“…The 32 studies included in this review represent a combined population of 1 083 264 new dialysis starters and 283 277 person‐years of observation for early mortality. The characteristics of these studies are shown in Table .…”

Section: Resultsmentioning

confidence: 99%

“…The number of patients who died in the early period, after the commencement of HD ranged between 3.9% and 30.1% (see Table ). The calculated early morality rates ranged between 11.0 and 122.0 per 100 person‐years. The weighted average of early mortality rates in all the included studies was 30.4 (95% CI 29.8–31.0) per 100 person‐years.…”

Section: Resultsmentioning

confidence: 99%

“…Three studies recruited their first patient in the 1970s , three in the 1980s , nine in the 1990s , and 16 in the period after 2000s . One study did not specify when their first patient was recruited .…”

Section: Resultsmentioning

confidence: 99%

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Early Mortality Rates After Commencement of Maintenance Hemodialysis: A Systematic Review and Meta‐Analysis

Hazara

Bhandari

2019

Ther Apher Dial

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Mortality rates are reported to be high soon after the commencement of maintenance HD for ESRD. Our aim was to estimate early mortality rates (deaths within 180 days of starting therapy), through a systematic review of literature, in this patient population. Medline and EMBASE were searched for publications between 1 January 1985 and 31 December 2017. Observational studies reporting deaths involving adults commencing HD were included. The Quality in Prognosis Studies tool was used to assess risk of bias in studies. Crude mortality rates (expressed in 100 person-years) and age-standardized mortality ratios (SMR) were calculated. Meta-analyses of these rates were conducted for studies with lowest risk of bias (i.e. highest quality). In total, 32 studies were included (combined population: 1 083 264) representing 283 277 person-years of observation; median follow-up: 90 days. Mortality rates ranged between 12.8 and 55.6 per 100 person-years. Cardiovascular causes accounted for the majority of early deaths. Meta-analysis of high-quality studies showed an overall crude mortality rate of 32.6 per 100 person-years (95% CI 32.4-32.8). This equates to 16.3% mortality in first 180 days of starting HD. Six highquality studies contained sufficient data for calculation of SMR. Meta-analysis of SMRs showed that patients starting HD therapy sustain 8.8 times higher mortality rates compared to the general population. We have combined the results of high-quality studies to produce new estimates of early mortality rates after commencement of HD therapy. This information can help relay more reliable prognostic information to this patient population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Early Mortality Rates After Commencement of Maintenance Hemodialysis: A Systematic Review and Meta‐Analysis

Hazara

Bhandari

2019

Ther Apher Dial

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“…Diabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus (DM) and a common cause of end-stage renal disease (ESRD). 1 Data show that about 40% of patients with DM have varying degrees of DN, and ~25% of them will progress to uremia. 1,2 Currently, DN is considered as a chronic inflammatory disease caused by various metabolic disorders.…”

Section: Introductionmentioning

confidence: 99%

“…1 Data show that about 40% of patients with DM have varying degrees of DN, and ~25% of them will progress to uremia. 1,2 Currently, DN is considered as a chronic inflammatory disease caused by various metabolic disorders. Therefore, inflammation plays a pivotal role in the development and progression of DN.…”

Section: Introductionmentioning

confidence: 99%

<p>Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway</p>

Han¹,

Pang²,

Zhang³

et al. 2020

DDDT

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Background: Inflammation-induced podocyte apoptosis plays an important role in kidney injury during diabetic nephropathy (DN). Hirudin (HIR), a natural compound extracted from leeches, can inhibit inflammation. However, whether HIR can protect the kidneys against inflammation during DN is unknown. In the present study, we aimed to study the effects of HIR on kidney damage in a DN rat model and explore its anti-inflammatory properties. Methods: A streptozotocin-induced DN rat model was generated, and HIR was administered subcutaneously. Immortal podocytes and primary peritoneal macrophages were used for vitro studies. Hematoxylin and eosin staining was used to evaluate renal pathological changes; quantitative polymerase chain reaction and immunoblotting were used to detect gene expression; and TUNEL staining was used to detect apoptotic cells. Results: Our results showed that HIR protected against renal injury, as indicated by kidney weight/body weight, serum creatinine, renal pathological changes, blood urea nitrogen, and detection of urine proteins. Notably, HIR treatment reduced macrophage infiltration, proinflammatory cytokine expression, and podocyte apoptosis in the kidney tissues of DN rats. In vitro, high glucose (HG) induced the activation of M1 macrophages, which was accompanied by increased podocyte apoptosis. HIR could decrease HG-induced podocyte apoptosis and suppress pro-inflammatory cytokine expression in podocytes in vitro. This was achieved via inhibition of p38 MAPK/NF-κB activation in renal tissues and podocytes. Conclusion: HIR could inhibit inflammation via the p38 MAPK/NF-κB pathway, prevent podocyte apoptosis, and protect against kidney damage in a DN rat model.

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Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis

Zhang,

Li,

Zhang

et al. 2024

Biomedicine & Pharmacotherapy

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Impact of gender and dialysis modality on early mortality risk in diabetic ESRD patients: data from a large single center cohort

Cited by 7 publications

References 30 publications

Early Mortality Rates After Commencement of Maintenance Hemodialysis: A Systematic Review and Meta‐Analysis

Early Mortality Rates After Commencement of Maintenance Hemodialysis: A Systematic Review and Meta‐Analysis

<p>Hirudin Protects Against Kidney Damage in Streptozotocin-Induced Diabetic Nephropathy Rats by Inhibiting Inflammation via P38 MAPK/NF-κB Pathway</p>

Hirudin delays the progression of diabetic kidney disease by inhibiting glomerular endothelial cell migration and abnormal angiogenesis

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